State-of-the-Art Advances of Medical Virology in Italy

A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Virology".

Deadline for manuscript submissions: 30 September 2026 | Viewed by 832

Special Issue Editors


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Guest Editor
1. UOC Virology and Microbiology, University Hospital “Luigi Vanvitelli”, 80138 Naples, Italy
2. Department of Woman, Child, and General and Specialized Surgery, University of Campania Luigi Vanvitelli, 80138 Naples, Italy
Interests: viral entry; viral pathogenesis; peptides; anti-viral peptide; diagnostic virology
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Department of Molecular and Translational Medicine, University of Brescia, Viale Europa, 11-25123 Brescia, Italy
Interests: HIV; human respiratory viruses; vaccines; gene therapy; viral oncology; cell/host interaction; endothelial cell dysfunction; cancer microenvironment; clinical virology
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Department of Life and Environmental Sciences, University of Cagliari, Cittadella Universitaria di Monserrato SS554, Monserrato, 09042 Cagliari, Italy
Interests: virology; microbiology; antiviral drugs; drug development; endogenous retroviruses; innate immunity
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Department of Molecular Medicine, Sapienza University of Rome, Viale del Policlinico 155, 00161 Rome, Italy
Interests: interferon: mechanism of action and production, antibodies to interferon in vivo, predictive markers of the response of interferons in patients; HIV; HCV: antiviral drugs, pathogenesis, virological markers; immunity: cell-mediated immunity, interferon gamma; respiratory viruses: infection and control; human papilloma viruses: infection and control; clinical virology
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Special Issue Information

Dear Colleagues,

In recent years, Italy has made significant contributions in the field of medical virology, not only advancing our understanding of viral pathogenesis but also leading innovative research in diagnostics, antiviral therapies, vaccine development, and epidemiological studies. These advances have had a profound impact not only on national health strategies but also on the global fight against viral infections.

This Special Issue of Microorganisms aims to showcase the latest research from Italy’s top virology laboratories. Contributions will include original studies, reviews, and methodological advances, highlighting Italy’s impact on understanding and managing viral diseases. Furthermore, it aims to provide a platform for further advancements in virology.

We invite researchers across disciplines to share their most recent findings and insights, fostering collaboration and innovation in virology. Join us in celebrating Italy’s excellence in virology and its vital role in advancing the science and understanding of viral diseases.

For submission details, please visit (https://www.mdpi.com/journal/microorganisms/special_issues/0QNNF9T9BJ).

Prof. Dr. Massimiliano Galdiero
Prof. Dr. Arnaldo Caruso
Prof. Dr. Enzo Tramontano
Prof. Dr. Guido Antonelli
Guest Editors

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Microorganisms is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • virology
  • viral pathogenesis
  • viral entry
  • viral replication
  • antivirals
  • viral diseases
  • viral vaccines
  • viral immunology
  • virus-host interactions

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Published Papers (1 paper)

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Research

17 pages, 2470 KB  
Article
The Tumor Cell Proliferation Inhibitory Activity of the Human Herpes Virus Type 6 U94 Protein Relies on a Stable Tridimensional Conformation
by Anna Bertelli, Matteo Uggeri, Federica Filippini, Melissa Duheric, Francesca Caccuri and Arnaldo Caruso
Microorganisms 2026, 14(1), 255; https://doi.org/10.3390/microorganisms14010255 - 22 Jan 2026
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Abstract
The U94 protein of Human Herpesvirus 6 exerts antiproliferative effects through downregulation of the Src proto-oncogene. We aimed to define the shortest U94 fragment that preserves antiproliferative activity and to explore its structural properties. U94 was truncated into shorter fragments, which were subjected [...] Read more.
The U94 protein of Human Herpesvirus 6 exerts antiproliferative effects through downregulation of the Src proto-oncogene. We aimed to define the shortest U94 fragment that preserves antiproliferative activity and to explore its structural properties. U94 was truncated into shorter fragments, which were subjected to computational analyses and proliferation assays on MDA-MB-468, BT-549 breast cancer cells. Src phosphorylation levels were scrutinized by Western blot analysis. Data obtained demonstrated that the U94 antiproliferative activity resides in its N-terminal region. Specifically, MT153 (aa 1–153) and MT117 (aa 1–117) fragments exhibited antiproliferative activity, whereas MV85 (aa 1–85) fragment did not. Computational analyses identified MG112 (aa 1–112) and MI108 (aa 1–108) as biologically active and suggested that the β-sheet of the structure is critical. The shortest KI95 fragment (aa 14–108), maintaining a stable β-sheet, demonstrated antiproliferative effects and Src downregulation. The antiproliferative activity of U94 and its active fragments relies on stable tridimensional conformation rather than on linear peptide sequence. KI95 represents the shortest active U94 fragment that preserves biological function, with critical residues likely located within the β-sheet region. These findings highlight the importance of structural integrity in U94 functionality and suggest KI95 as a potential therapeutic agent for cancer treatment. Full article
(This article belongs to the Special Issue State-of-the-Art Advances of Medical Virology in Italy)
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