Special Issue "Viral Evasion of Innate Immunity and Drug Development"

A special issue of Viruses (ISSN 1999-4915). This special issue belongs to the section "Viral Immunology, Vaccines, and Antivirals".

Deadline for manuscript submissions: 31 December 2021.

Special Issue Editors

Prof. Dr. Enzo Tramontano
E-Mail Website
Guest Editor
Department of Life and Environmental Sciences, University of Cagliari, 09124 Cagliari, Italy
Interests: virology; microbiology; antiviral drugs; drug development; endogenous retroviruses; innate immunity
Special Issues and Collections in MDPI journals
Prof. Dr. Pierre-Olivier Vidalain
E-Mail Website
Guest Editor
Equipe VIRIMI—Infections Virales, Métabolisme et Immunité Centre International de Recherche en Infectiologie (CIRI)—INSERM U1111—CNRS UMR5308 Université Lyon 1, 69365 Lyon, France
Interests: chemobiology; interferon; innate immunity; immunostimulatory molecules; immunometabolism; host-directed antivirals

Special Issue Information

Dear Colleagues,

Antiviral innate immunity is an ancestral defense system against viruses. It is essentially based on pattern recognition receptors (PRR) which recognize pathogen associated molecular patterns (PAMPs). In vertebrates, viral PAMPs activate signaling cascades leading to the production of cytokines, especially interferons (IFNs), and trigger critical antiviral mechanisms including: nuclease activation; translation inhibition; metabolic reprogramming; autophagy; cell death; and inflammation. On the one hand, pathogenic viruses have developed a variety of systems to evade innate immunity, while on the other hand, overactivation of the innate immune system can be deleterious to the individual, with the overproduction of cytokines and IFNs leading to pathological events. The Special Issue is devoted to (i) characterizing the mechanisms by which viral proteins evade the innate immune system; (ii) the development of drugs that are active on both viral and cellular proteins to counteract the immune evasion displayed by viruses; (iii) the development of drugs that shut off the innate immune system when overactivated in specific pathological conditions.

Prof. Dr. Enzo Tramontano
Prof. Dr. Pierre-Olivier Vidalain
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Viruses is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • innate immunity
  • interferon (IFN)
  • viral evasion
  • drug development
  • viral inhibition
  • IFN production/signaling activation
  • IFN production/signaling inhibition
  • antiviral immunotherapy
  • host-directed antivirals

Published Papers

This special issue is now open for submission.
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