Micro Photonic Devices for Optogenetics and Fibre Photometry
A special issue of Micromachines (ISSN 2072-666X). This special issue belongs to the section "B：Biology and Biomedicine".
Deadline for manuscript submissions: closed (15 November 2021) | Viewed by 254
Special Issue Editor
Special Issue Information
Dear Colleagues,
Fibre photometry and optogenetics are two complementary techniques that are revolutionizing our understanding of neural circuits. Fibre photometry allows researchers to read neural activity optically. It relies on fluorescent indicators that respond to changes in voltage, calcium, or other markers of neural activity. By monitoring the fluorescent output, researchers can begin to associate the activity of neurons with specific behaviours. Optogenetics, on the other hand, allows researchers to modulate neural signals with high temporal precision using light. A broad range of optogenetic constructs have been developed to both activate and inhibit neural activity. Optogenetic techniques have also been suggested for treating a variety of human conditions.
Getting light into and out of the highly scattering neural tissue remains a significant challenge. The simple approach of implanting a single optic fibre provides a robust single illumination/collection site and has proved useful in developing the techniques of fibre photometry and optogenetics. However, more sophisticated microlight sources are needed to continue the development of this field. Accordingly, this Special Issue seeks to showcase research papers, communications, and review articles that focus on microphotonic devices for optogenetics and fibre photometry.
Dr. Niall McAlinden
Guest Editor
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Keywords
- optogenetics
- fibre photometry
- neurotechnology
- photonic probes
- system-on-chip
- wireless
- flexible electronics
- microLEDs
- RCLEDs
- VCSEL
- diode lasers
- optical fibres
- waveguides
- microfluidics
- single-photon avalanche diodes
- photodetectors
- fluorescence
- in vivo experiments
- neural imaging
- ChR2
- GCaMP
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