Special Issue "Microfluidic Cell Culture, Monitoring and Analysis (CCMA) Systems"

A special issue of Micromachines (ISSN 2072-666X). This special issue belongs to the section "B:Biology and Biomedicine".

Deadline for manuscript submissions: closed (20 November 2019) | Viewed by 112

Special Issue Editor

Prof. Dr. Jan Gimsa
E-Mail Website1 Website2
Guest Editor
Department of Biophysics, University of Rostock, Gertrudenstr. 11a, 18057 Rostock, Germany
Interests: electric impedance; AC-electrokinetics; dielectrophoresis; electrorotation; lab-on-a-chip (LOC); on-chip sensors; microfluidics; electrothermal micro-pumps

Special Issue Information

Dear Colleagues,

Research on microfluidic cell culture, monitoring and analysis (CCMA) systems is of growing importance in the biological, medical and pharmacological sciences. CCMA systems are based on Lab-on-a-Chip (LOC) and Micro Total Analysis Systems (µTAS) technologies. They can be produced by established manufacturing techniques such as photolithography or a variety of polymer technologies. The systems’ key advantage is the reduced consumption of cells and reagents, while a large number of tests can be performed in parallel with a high analytical throughput. CCMA systems call for the integration of actuators, microreaction techniques and sensors such as micropumps or electrical sensors for physical and chemical parameters, as well as for specific metabolites or gene sequences.

Up to now, many systems have been based on 2D cell cultures, cell monitoring by microscopic techniques and analysis by different types of endpoint assays, such as ELISAs or life-death assays. Only a few commercial systems are available for the online monitoring of such physiologically relevant parameters as acidification, respiration, specific substances such as lactate, as well as changes in the electrical impedance of interdigitated electrode structures to detect the proliferation of adherent cells. The integrative or even purely physical nature of the parameters recorded poses foreseeable problems in converting recorded data in a biologically significant way using systems biology approaches. If physiological cell parameters are recorded during long-term cultivation, the systems can be used to reduce the number of animal experiments in medical diagnostics or drug development (cf. 3R principle: replace, reduce, refine).

This special issue presents research work, brief communications and review articles on new developments in the manufacture and application of microfluidic CCMA systems, with particular interest in biological applications and the advancement of new sensors, microfluidic actuators and approaches to the interpretation of sensor readouts.

Prof. Dr. Jan Gimsa
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Micromachines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Lab-on-a-chip (LOC)
  • Micro Total Analysis Systems (µTAS)
  • Microfluidic MEMS
  • 3R principle
  • Absorption, distribution, metabolism, and excretion (ADME)
  • On-chip sensors
  • pH sensors
  • Oxygen sensors
  • IDES
  • Systems biology

Published Papers

There is no accepted submissions to this special issue at this moment.
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