Microfluidic Platform for Bio-Sample Preparation and Analysis

Dear Colleagues,

Biofluid (i.e., blood, saliva, urine, or sweat) gives clinical information on the status of a patient’s health and disease. For example, red blood cells (RBCs) play an important role in transporting gases and removing wastes between peripheral tissues and capillary vessels. When blood flows in micron-sized capillary channels (i.e., microcirculation), blood flow is determined by fluidic resistance-related factors under certain pressure drop conditions. The fluidic resistance is varied and influenced by biomechanical properties (i.e., hematocrit, viscosity or viscoelasticity, aggregation, deformability, and surface adhesion). These biomechanical properties of blood have been regarded as clinical important biomarkers for screening or diagnosing diseases under in situ or laboratory conditions. For this reason, consistent quantification of blood flow is being considered as an important issue in blood biophysics fields. Recently, microfluidics has been employed to quantify blood flows under blood vessel-mimicking microfluidic channels. When red blood cells are altered into an abnormal physiological state, biophysical properties or morphology parameters (i.e., surface area, volume, or density) become significantly and heterogeneously varied. For early detection, novel microfluidic platforms or medical devices should be addressed to detect small variations or subpopulations in whole blood. This Special Issue welcomes manuscripts related to the following topics, but is not limited to them:

1. Blood-on-a-chip for quantification of hemorheological properties;
2. Single cell morphology analysis of bio-sample;
3. Mathematical modeling under micro-scale physics;
4. Disposable microfluidic device for POCT test;
5. Experimental visualization technique under microfluidic platform;
6. Microfluidic device for quantifying heterogeneity of red blood cells;
7. Microfluidic device for handing or analyzing biofluids;
8. Blood-on-a-chip;
9. Disposable POCT device;
10. Heterogeneity of RBCs;
11. On-chip detection of hemorheological properties of blood;
12. POCT device to evaluate RBCs’ flow properties;
13. Microfluidic systems with integrated sensors for single-red-blood-cell analysis;

Prof. Dr. Yang Jun Kang
Dr. Ami Mehta-Doshi
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Micromachines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2100 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• blood-on-a-chip for quantification of hemorheological properties
• single cell morphology analysis of bio-sample
• mathematical modeling under micro-scale physics
• disposable microfluidic device for POCT test
• experimental visualization technique under microfluidic platform
• microfluidic device for quantifying heterogeneity of red blood cells
• microfluidic device for handing or analyzing biofluids
• blood-on-a-chip
• disposable POCT device
• heterogeneity of RBCs
• on-chip detection of hemorheological properties of blood
• POCT device to evaluate RBCs’ flow properties
• microfluidic systems with integrated sensors for single-red-blood-cell analysis