Cell-Based Microarrays

Dear Colleagues,

In 2001, Ziauddin and Sabatini introduced the first cell-based microarray as a microarray-driven gene expression system. In the original set-up, different cDNA vectors were printed on a glass support. After, cells were grown over the whole surface, thus resulting in a cellular response in the printed locations. Subsequent publications have matched the technique to diverse applications involving RNAi and compounds. The potential of this method for performing gene function analysis and for identifying novel therapeutic targets and agents has now been clearly shown. Thus, cell-based microarrays have become an appreciated tool in basic research and drug discovery.

The advancement of miniaturized cell-based microarrays offers a multitude of advantages that are out of reach for conventional macroscale cell screening methods, which use microtiter plates. Amongst other advantages, the small dimensions of typical cell-based microarrays greatly reduce consumables, cell and drug consumption; this advantage is particularly important for rare cell analysis and cost reductions.

In this Special Issue, we invite material regarding new developments, technological advancements, and applications involving cell-based microarrays. Information about the new developments associated with data analysis and data mining is also critical in the area of cell-based microarrays.

Dr. Holger Erfle
Guest Editor

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Microarrays is an international peer-reviewed open access quarterly journal published by MDPI.

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