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Metabolites
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Nutrition and Dietary Supplementation in the Context of Health, Disease,...
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Nutrition and Dietary Supplementation in the Context of Health, Disease, and Physical Performance

A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Nutrition and Metabolism".

Deadline for manuscript submissions: 25 July 2026 | Viewed by 529

Special Issue Editors

Dr. Magdalena Górnicka

E-Mail Website
Guest Editor
Department of Human Nutrition, Institute of Human Nutrition Sciences, Warsaw University of Life Sciences (SGGW-WULS), Nowoursynowska 159C, 02-776 Warsaw, Poland
Interests: nutrition; bioactive compounds; metabolic disorders; nutritional assessment
Special Issues, Collections and Topics in MDPI journals
Dr. Ewa Niedźwiedzka

E-Mail Website
Guest Editor
Department of Human Nutrition, Faculty of Food Sciences, University of Warmia and Mazury in Olsztyn, 10-719 Olsztyn, Poland
Interests: nutrition; metabolic disorders; public health nutrition; diet quality
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue, entitled ‘Nutrition and Dietary Supplementation in the Context of Health, Disease, and Physical Performance’, aims to provide a comprehensive understanding of the role of diet and bioactive compounds in supporting performance and health. Diet, individual food compound intake, and physical effort shape metabolism and body composition. Both nutrients and their metabolites constitute key biological and functional outputs linking metabolic pathways with health and disease. Advances in research methods and techniques, such as omics, make it possible to capture subtle changes in the metabolome as a result of different dietary patterns or dietary interventions. The overall focus of this Special Issue is to investigate the effect of food components and dietary intervention on changes in performance. Metabolic biomarkers include various components, such as body composition, inflammation, oxidative stress, amino acids, and fatty acid profiles. This Special Issue unravels their associations with diet, dietary patterns, dietary intervention, dietary supplements, and bioactive compounds. The Editors invite original studies and reviews (systematic reviews, meta-analyses, and narrative reviews). This Special Issue includes original research and review articles on the role of nutrition and supplementation in shaping health, preventing or supporting the treatment of diseases, and impacting physical performance in various age groups. Topics may include the following:

  • The impact of individual nutrients and dietary supplements on health and physiological functions.
  • Nutritional strategies to support physical exercise, recovery, and training adaptation.
  • The relationship between diet, supplementation, and markers of health or disease.
  • Papers focus on athletes, physically active individuals, clinical patients, and the general population.

Dr. Magdalena Górnicka
Dr. Ewa Niedźwiedzka
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • diet
  • dietary pattern
  • bioactive food compounds
  • body composition
  • nutrition-related biomarkers
  • metabolites
  • physical activity

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Published Papers (1 paper)

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Review

32 pages, 759 KB  
Review
Lean Mass and Musculoskeletal Preservation in GLP-1-Based Obesity Treatment: Nutrition, Exercise, Supplementation, and Monitoring Strategies
by Roko Šantić, Lovre Martinović, Nikola Pavlović, Doris Rušić, Marko Kumrić, Dinko Martinović, Tina Tičinović Kurir and Joško Božić
Metabolites 2026, 16(6), 364; https://doi.org/10.3390/metabo16060364 - 27 May 2026
Viewed by 90
Abstract
Background/Objectives: GLP-1-based obesity pharmacotherapy has shifted clinical attention from the magnitude of weight loss to the quality of weight loss. This review evaluates whether body composition changes during treatment with GLP-1-based agents represent clinically meaningful muscle loss and identifies nutrition, supplementation, exercise, and [...] Read more.
Background/Objectives: GLP-1-based obesity pharmacotherapy has shifted clinical attention from the magnitude of weight loss to the quality of weight loss. This review evaluates whether body composition changes during treatment with GLP-1-based agents represent clinically meaningful muscle loss and identifies nutrition, supplementation, exercise, and monitoring strategies that may help preserve lean mass, function, bone health, and nutritional adequacy. Methods: A comprehensive narrative review was performed using focused searches of PubMed, publisher-hosted journal platforms, and reference lists of key primary studies and recent evidence syntheses through March and May 2026. Evidence was organized around body composition, muscle quality and function, dietary protein and micronutrient adequacy, exercise, supplementation, bioelectrical impedance analysis, imaging, and emerging biomarkers. Results: Semaglutide and tirzepatide preferentially reduce fat mass, including visceral and ectopic adiposity, while producing smaller but consistent reductions in lean mass or lean soft tissue. However, DXA-derived lean mass and BIA-derived fat-free mass are not equivalent to skeletal muscle, and lean tissue loss does not necessarily indicate impaired strength or physical performance. The most defensible supportive care model combines food-first nutritional counseling, adequate protein intake, structured resistance exercise, management of gastrointestinal adverse effects, and risk-based monitoring of micronutrient inadequacy. Protein supplementation and nutritionally complete meal replacements may be useful when intake is insufficient, whereas creatine, essential amino acids or leucine, beta-hydroxy-beta-methylbutyrate, fiber, probiotics, omega-3 fatty acids, and multi-ingredient products remain adjunctive options supported mainly by indirect or phenotype-specific evidence. Conclusions: Future GLP-1 trials and clinical care should move beyond body weight and total lean mass toward integrated assessment of muscle quantity, muscle quality, function, bone, and nutritional adequacy, and standardized BIA-based clinical monitoring where advanced imaging is not feasible. Full article
(This article belongs to the Special Issue Nutrition and Dietary Supplementation in the Context of Health, Disease, and Physical Performance)
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