Special Issue "Metabolic Engineering and Synthetic Biology"
A special issue of Metabolites (ISSN 2218-1989).
Deadline for manuscript submissions: closed (30 October 2015)
Dr. Dirk Steinhauser
In bioengineering, observation and identification, analyzing and understanding (disassembling) as well as re-/design and evaluation (assembling) are crucial key components. The recent maturation and application of post-genomic technologies in biology provide novel opportunities for metabolic engineering and synthetic biology. On the one hand, biological functions can be studied within and between systems levels to acquire a rather holistic understanding of how complex biological systems are operating. This enables the extraction of functional and regulatory design principles for the optimization of existing and the establishment of novel and synthetic metabolic routes as well as for the construction of orthogonal biological systems. On the other hand, ‘-omics’ technologies can be utilized as fast and comprehensive readout to evaluate a rational or evolutionary engineered system towards the expected output, undesired side effects and to detect remaining constrains as targets for further optimizations. Moreover, the large quantities of accumulated ‘-omics’ level data, in particular genome information, may facilitate the identification of evolutionary conserved as well as unique and novel design principles via comparative computational approach.
In this special issue we encourage the submissions of original research papers and review articles focusing on bioengineering and synthetic biology with special emphasis on metabolism and metabolic as well as metabolite-associated regulatory pathways. Topics that will be covered by this special issue include (not exclusively): reverse metabolomics and engineering; rational and evolutionary engineering; metabolic design principles and chemical/regulatory circuit logic; computational and mathematic models; molecule and pathway design; tools and resources in metabolic engineering and synthetic biology. Furthermore, manuscripts related to exploiting metabolic diversity for metabolic engineering, for lead compound and pathway discovery or dealing with other challenging issues in metabolic engineering and synthetic biology are also welcome.
Dr. Dirk Steinhauser
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- synthetic biology
- reverse metabolomics and engineering
- rational and evolutionary engineering
- chemical engineering
- molecule and pathway design and redesign
- metabolic design principles
- computational and mathematical models
- tools and resources
- variation and selection
- metabolic diversity