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Advances in Metabolic Engineering of Cyanobacteria for Photosynthetic Biochemical Production

Undergraduate Honors Program of Nano Science and Engineering, National Chiao Tung University, Hsinchu 300, Taiwan
Department of Biological Science and Technology, National Chiao Tung University, Hsinchu 300, Taiwan
Author to whom correspondence should be addressed.
Academic Editor: Peter Meikle
Metabolites 2015, 5(4), 636-658;
Received: 2 July 2015 / Revised: 30 September 2015 / Accepted: 22 October 2015 / Published: 27 October 2015
(This article belongs to the Special Issue Metabolic Engineering and Synthetic Biology)
PDF [818 KB, uploaded 27 October 2015]


Engineering cyanobacteria into photosynthetic microbial cell factories for the production of biochemicals and biofuels is a promising approach toward sustainability. Cyanobacteria naturally grow on light and carbon dioxide, bypassing the need of fermentable plant biomass and arable land. By tapping into the central metabolism and rerouting carbon flux towards desirable compound production, cyanobacteria are engineered to directly convert CO2 into various chemicals. This review discusses the diversity of bioproducts synthesized by engineered cyanobacteria, the metabolic pathways used, and the current engineering strategies used for increasing their titers. View Full-Text
Keywords: metabolic engineering; cyanobacteria metabolic engineering; cyanobacteria

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Lai, M.C.; Lan, E.I. Advances in Metabolic Engineering of Cyanobacteria for Photosynthetic Biochemical Production. Metabolites 2015, 5, 636-658.

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