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Metabolites
Special Issues
Colon Cancer Metabolism
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Colon Cancer Metabolism

A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Endocrinology and Clinical Metabolic Research".

Deadline for manuscript submissions: closed (30 June 2021) | Viewed by 3372

Special Issue Editor

Dr. Sajid A. Khan

E-Mail
Guest Editor
Department of Surgery, Section of Surgical Oncology, Yale University School of Medicine，New Haven, CT, USA
Interests: gastrointestinal cancers

Special Issue Information

Globally, colon cancer remains one of the commonly diagnosed cancers and largest causes of cancer death. Understanding the complex interactions by which colon metabolism influences the development of colon cancer has been a research challenge, but recent years have seen advances in this field. This section of the journal will focus on studies that investigate interactions between metabolites and colon cancer tumor biology, and global clinical relevance. Topics of interest include:

  • Influence of bile acids resulting in promoting carcinogenesis;
  • Dietary risk which is mediated by colorectal microbiome;
  • Impact of meat consumption and fiber-rich foods on colorectal cancer risk;
  • Impact of obesity on development of colorectal cancer.

Dr. Sajid A. Khan
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • colon cancer
  • colorectal cancer
  • microbiome
  • bile acids
  • obesity
  • dietary consumption

Published Papers (1 paper)

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Research

12 pages, 1973 KiB  
Article
Azoxymethane Alters the Plasma Metabolome to a Greater Extent in Mice Fed a High-Fat Diet Compared to an AIN-93 Diet
by Huawei Zeng, Shahid Umar, Zhenhua Liu and Michael R. Bukowski
Metabolites 2021, 11(7), 448; https://doi.org/10.3390/metabo11070448 - 09 Jul 2021
Cited by 1 | Viewed by 2746
Abstract
Consumption of a high-fat diet (HFD) links obesity to colon cancer in humans. Our data show that a HFD (45% energy fat versus 16% energy fat in an AIN-93 diet (AIN)) promotes azoxymethane (AOM)-induced colonic aberrant crypt foci (ACF) formation in a mouse [...] Read more.
Consumption of a high-fat diet (HFD) links obesity to colon cancer in humans. Our data show that a HFD (45% energy fat versus 16% energy fat in an AIN-93 diet (AIN)) promotes azoxymethane (AOM)-induced colonic aberrant crypt foci (ACF) formation in a mouse cancer model. However, the underlying metabolic basis remains to be determined. In the present study, we hypothesize that AOM treatment results in different plasma metabolomic responses in diet-induced obese mice. An untargeted metabolomic analysis was performed on the plasma samples by gas chromatography time-of-flight mass spectrometry (GC-TOF-MS). We found that 53 of 144 identified metabolites were different between the 4 groups of mice (AIN, AIN + AOM, HFD, HFD + AOM), and sparse partial least-squares discriminant analysis showed a separation between the HFD and HFD + AOM groups but not the AIN and AIN + AOM groups. Moreover, the concentrations of dihydrocholesterol and cholesterol were inversely associated with AOM-induced colonic ACF formation. Functional pathway analyses indicated that diets and AOM-induced colonic ACF modulated five metabolic pathways. Collectively, in addition to differential plasma metabolomic responses, AOM treatment decreases dihydrocholesterol and cholesterol levels and alters the composition of plasma metabolome to a greater extent in mice fed a HFD compared to the AIN. Full article
(This article belongs to the Special Issue Colon Cancer Metabolism)
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