Zebrafish: A Model for the Study of Human Metabolism Diseases

A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Endocrinology and Clinical Metabolic Research".

Deadline for manuscript submissions: closed (31 August 2021) | Viewed by 5112

Special Issue Editor


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Guest Editor
Molecular & Cellular Biochemistry, University of Kentucky, Lexington, KY 40536, USA
Interests: cancer; zebrafish; genetics; cancer biomarkers; drug resistance; stem cells

Special Issue Information

Dear Colleagues,

Zebrafish are a powerful tool to study a wide variety of human diseases, from developmental abnormalities to cancer. They have recently emerged as an important model system in research on metabolic function and metabolic disease. The metabolism involves a complex interplay between multiple organ systems and endocrine signalling. This level of complexity cannot be recreated in in vitro systems. Zebrafish possess all of the key organs needed for metabolic function in humans, and many of the proteins and pathways involved in the metabolism are highly conserved between zebrafish and mammals. Additionally, zebrafish are a low-cost model system for use in large-scale assays, are relatively easy to genetically manipulate, and are excellent for live animal imaging. This Special Issue will highlight the use of zebrafish in research related to human metabolism and metabolic disorders, either at the whole-organism level or in a single cell. Topics can include, but are not limited to, zebrafish models of metabolic disease, new technological applications, genomic approaches, high-throughput chemical screening, cross-species data comparisons, and biomarkers.

Dr. Jessica Blackburn
Guest Editor

Manuscript Submission Information

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Keywords

  • Zebrafish
  • Metabolomics
  • Transgenic
  • Imaging
  • Mass Spectrometry
  • Metabolic Regulation
  • Obesity
  • Diabetes
  • Cancer
  • Drug Discovery
  • Regeneration
  • Toxicology

Published Papers (1 paper)

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Review

24 pages, 14847 KiB  
Review
Mass Spectrometry-Based Zebrafish Toxicometabolomics: A Review of Analytical and Data Quality Challenges
by Katyeny Manuela da Silva, Elias Iturrospe, Chloe Bars, Dries Knapen, Steven Van Cruchten, Adrian Covaci and Alexander L. N. van Nuijs
Metabolites 2021, 11(9), 635; https://doi.org/10.3390/metabo11090635 - 17 Sep 2021
Cited by 12 | Viewed by 4297
Abstract
Metabolomics has achieved great progress over the last 20 years, and it is currently considered a mature research field. As a result, the number of applications in toxicology, biomarker, and drug discovery has also increased. Toxicometabolomics has emerged as a powerful strategy to [...] Read more.
Metabolomics has achieved great progress over the last 20 years, and it is currently considered a mature research field. As a result, the number of applications in toxicology, biomarker, and drug discovery has also increased. Toxicometabolomics has emerged as a powerful strategy to provide complementary information to study molecular-level toxic effects, which can be combined with a wide range of toxicological assessments and models. The zebrafish model has gained importance in recent decades as a bridging tool between in vitro assays and mammalian in vivo studies in the field of toxicology. Furthermore, as this vertebrate model is a low-cost system and features highly conserved metabolic pathways found in humans and mammalian models, it is a promising tool for toxicometabolomics. This short review aims to introduce zebrafish researchers interested in understanding the effects of chemical exposure using metabolomics to the challenges and possibilities of the field, with a special focus on toxicometabolomics-based mass spectrometry. The overall goal is to provide insights into analytical strategies to generate and identify high-quality metabolomic experiments focusing on quality management systems (QMS) and the importance of data reporting and sharing. Full article
(This article belongs to the Special Issue Zebrafish: A Model for the Study of Human Metabolism Diseases)
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