Skeletal Muscle Thermogenesis and Energy Metabolism
A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Endocrinology and Clinical Metabolic Research".
Deadline for manuscript submissions: closed (15 January 2022) | Viewed by 14188
Special Issue Editors
Interests: ageing; sarcopenia; diabetes; metabolism
Special Issue Information
Dear Colleagues,
Temperature homeostasis (37 ºC) is essential for optimal physiological activity and the survival of endotherms (birds and mammals). Both shivering and nonshivering thermogenic mechanisms (NST) contribute to temperature homeostasis. In mammals, skeletal muscle and brown adipose tissue (BAT) are major sites of thermogenesis and play key roles in temperature homeostasis. Lately, there has been considerable interest in activating BAT-mediated NST in adult humans to increase energy metabolism. However, the relative paucity of BAT in adult humans and its absence in obese individuals makes it relatively inefficient in increasing metabolism and regulating obesity. On the other hand, skeletal muscle-based shivering and NST mechanisms remain active throughout adult life and are the primary means for heat production in most mammals, including humans. Another advantage is that skeletal muscle represents ~40–45% of body mass and recruitment of skeletal muscle activity through shivering, and NST mechanisms (especially activation of futile SERCA activity) can be effective to increase energy expenditure and whole-body metabolism. In addition, a combination of cold and exercise could be more effective in enhancing muscle energy expenditure and whole-body metabolism in humans. The aim and scope of this Special Issue is to identify the different mechanisms of muscle thermogenesis and discuss their relevance to whole-body metabolism in mammals.
Dr. Muthu Periasamy
Dr. Naresh Chandra Bal
Guest Editors
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