Stress and Inflammation: Drivers, Biomarkers and Physiological Effects

A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Endocrinology and Clinical Metabolic Research".

Deadline for manuscript submissions: closed (9 June 2025) | Viewed by 1703

Special Issue Editor


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Guest Editor
Department of Evolutionary Anthropology, Duke University, Durham, NC, USA
Interests: physical activity; nutrition; obesity; stress; rural health disparities; digital health

Special Issue Information

Dear Colleagues,

Stress is associated with a wide range of chronic diseases, and inflammation is a key mechanism linking stress to the pathophysiological processes driving these disease states. Stress and inflammation are impacted by obesity and modifiable health behaviors, such as physical activity and nutritional intakes. However, stress and inflammation are also linked to environmental and psychosocial drivers, such as poverty, stigma, discrimination, built environments, and exposure to pollutants and pathogens. The purpose of this Special Issue is to discuss the effects of these multifaceted stimuli on stress and inflammation outcomes, methods for quantifying stress and inflammation, and the physiological effects of stress and inflammation. Both reviews and original research submissions are welcome, and all forms of original research (e.g., qualitative, quantitative, observational, experimental) will be considered for publication. In line with the scope of Metabolites, all submissions should include a substantive emphasis on at least one metabolite, biomarker, or metabolic pathway related to stress or inflammation.

Dr. Eric Trexler
Guest Editor

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Keywords

  • physical activity
  • nutrition
  • health behavior
  • obesity
  • stress
  • inflammation
  • biomarkers

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Published Papers (1 paper)

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Research

13 pages, 574 KiB  
Article
Application of Craniosacral Therapy Versus Blood Levels of Corticoliberin and Oxytocin in Male Firefighters Exposed to Occupational Stress—A Randomised Control Trial
by Małgorzata Wójcik and Idzi Siatkowski
Metabolites 2025, 15(6), 374; https://doi.org/10.3390/metabo15060374 - 6 Jun 2025
Viewed by 1317
Abstract
Background: Firefighters’ work exposes them to high levels of stress. Oxytocin (OXT) and corticotrophin-releasing hormone (CRH) are hormones released in response to stress. Prolonged exposure to stress can have negative effects, such as increased blood pressure and glucose levels, and a weakened [...] Read more.
Background: Firefighters’ work exposes them to high levels of stress. Oxytocin (OXT) and corticotrophin-releasing hormone (CRH) are hormones released in response to stress. Prolonged exposure to stress can have negative effects, such as increased blood pressure and glucose levels, and a weakened immune system. Methods: This study involved 57 fire department cadets, randomly divided into craniosacral therapy (CS) and contralateral therapy (CO) groups. This study aimed to check whether 5-week craniosacral therapy affects CRH and OXT levels, determined from blood. Results: For the CS group, CRH_1 and CRH_2 showed slight increases in median values, 1.73 vs. 2.16, and OXT_1 and OXT_2 showed significant increases in median values, 54.71 vs. 57.77. Spearman’s correlation coefficient for CRH_1 vs. OXT_1 was r = 0.26, p = 0.124; similarly, for CRH_2 vs. OXT_2 was r = −0.02, p = 0.920; for CRH_ 1 vs. CRH_2 was r = 0.25, p = 0.173; and for OXT_1 vs. OXT_2 was r = 0.77, p < 0.00001. The values of the point statistics for CRH were similar in CO_1 and CS_1. After the end of therapy, in the CS_2 group, the values of the point statistics were greater than those for the CO_2 group. The median values for oxytocin in the CO_1 group were greater than those in the CS_1 group. After the end of therapy, in the CO_2 group, the values of the scoring statistics were smaller than those for the CS_2 group. The effect of the intervention in the CS group and the CO group showed a significance of p = 0.0003 and p = 0.023. Conclusions: After the end of therapy, a significant increase in OXT levels was observed, as well as a slight increase in CRH levels. Full article
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