Special Issue "Optical Assessment of Metabolism"

A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Metabolomic Profiling Technology".

Deadline for manuscript submissions: closed (30 November 2021).

Special Issue Editor

Dr. Wesley Baker
E-Mail Website
Guest Editor
The Children's Hospital of Philadelphia, Philadelphia, PA, USA
Interests: functional near-infrared spectroscopy; diffuse correlation spectroscopy; cerebral hemodynamics; multimodal neuromonitoring; neurocritical care bioinformatics

Special Issue Information

Dear Colleagues, 

Optical techniques have been employed with remarkable success over the last two decades to probe hemodynamic processes in highly scattering tissues such as the brain, muscle and breast. In total, this research has discovered new indicators of tissue function and health that are proving to be clinically relevant. This Special Issue highlights advances in the development and application of optical techniques for assessment of metabolic activity. We therefore welcome innovative manuscripts that feature optical methods for measuring metabolism and metabolites, optical biomarkers of mitochondrial health, validations of optical metabolism metrics, optical assessment of mitochondrial pathophysiology in human patients and preclinical models, and clinical applications of metabolic measurements. 

This Special Issue aims to provide a broad summary of recent developments in the field and also inform future directions for optical metabolism research. It is open for submission now. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the Special Issue website.

Dr. Wesley Baker
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Functional near-infrared spectroscopy
  • Diffuse correlation spectroscopy
  • Metabolite biomarkers
  • Oxygen metabolism
  • Mitochondria
  • Optical imaging
  • Clinical applications

Published Papers (2 papers)

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Research

Article
Exercise Training Increases Resting Calf Muscle Oxygen Metabolism in Patients with Peripheral Artery Disease
Metabolites 2021, 11(12), 814; https://doi.org/10.3390/metabo11120814 - 29 Nov 2021
Viewed by 304
Abstract
Exercise training can mitigate symptoms of claudication (walking-induced muscle pain) in patients with peripheral artery disease (PAD). One adaptive response enabling this improvement is enhanced muscle oxygen metabolism. To explore this issue, we used arterial-occlusion diffuse optical spectroscopy (AO-DOS) to measure the effects [...] Read more.
Exercise training can mitigate symptoms of claudication (walking-induced muscle pain) in patients with peripheral artery disease (PAD). One adaptive response enabling this improvement is enhanced muscle oxygen metabolism. To explore this issue, we used arterial-occlusion diffuse optical spectroscopy (AO-DOS) to measure the effects of exercise training on the metabolic rate of oxygen (MRO2) in resting calf muscle. Additionally, venous-occlusion DOS (VO-DOS) and frequency-domain DOS (FD-DOS) were used to measure muscle blood flow (F) and tissue oxygen saturation (StO2), and resting calf muscle oxygen extraction fraction (OEF) was calculated from MRO2, F, and blood hemoglobin. Lastly, the venous/arterial ratio (γ) of blood monitored by FD-DOS was calculated from OEF and StO2. PAD patients who experience claudication (n = 28) were randomly assigned to exercise and control groups. Patients in the exercise group received 3 months of supervised exercise training. Optical measurements were obtained at baseline and at 3 months in both groups. Resting MRO2, OEF, and F, respectively, increased by 30% (12%, 44%) (p < 0.001), 17% (6%, 45%) (p = 0.003), and 7% (0%, 16%) (p = 0.11), after exercise training (median (interquartile range)). The pre-exercise γ was 0.76 (0.61, 0.89); it decreased by 12% (35%, 6%) after exercise training (p = 0.011). Improvement in exercise performance was associated with a correlative increase in resting OEF (R = 0.45, p = 0.02). Full article
(This article belongs to the Special Issue Optical Assessment of Metabolism)
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Article
Diffuse Optical Spectroscopy Assessment of Resting Oxygen Metabolism in the Leg Musculature
Metabolites 2021, 11(8), 496; https://doi.org/10.3390/metabo11080496 - 29 Jul 2021
Cited by 1 | Viewed by 762
Abstract
We lack reliable methods to continuously assess localized, resting-state muscle activity that are comparable across individuals. Near-infrared spectroscopy (NIRS) provides a low-cost, non-invasive means to assess localized, resting-state muscle oxygen metabolism during venous or arterial occlusions (VO2VO and VO2AO, respectively). [...] Read more.
We lack reliable methods to continuously assess localized, resting-state muscle activity that are comparable across individuals. Near-infrared spectroscopy (NIRS) provides a low-cost, non-invasive means to assess localized, resting-state muscle oxygen metabolism during venous or arterial occlusions (VO2VO and VO2AO, respectively). However, this technique is not suitable for continuous monitoring, and its utility is limited to those who can tolerate occlusions. Combining NIRS with diffuse correlated spectroscopy (DCS) enables continuous measurement of an index of muscle oxygen metabolism (VO2i). Despite the lack of previous validation, VO2i is employed as a measure of oxygen metabolism in the muscle. Here we characterized measurement repeatability and compared VO2i with VO2VO and VO2AO in the medial gastrocnemius (MG) in 9 healthy adults. Intra-participant repeatability of VO2i, VO2VO, and VO2AO were excellent. VO2i was not significantly correlated with VO2AO (p = 0.15) nor VO2VO (p = 0.55). This lack of correlation suggests that the variability in the calibration coefficient between VO2i and VO2AO/VO2VO in the MG is substantial across participants. Thus, it is preferable to calibrate VO2i prior to every monitoring session. Important future work is needed to compare VO2i against gold standard modalities such as positron emission tomography or magnetic resonance imaging. Full article
(This article belongs to the Special Issue Optical Assessment of Metabolism)
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