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Metabolites
Special Issues
Interplay Between Metabolic Adaptations to Physical Activity
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Interplay Between Metabolic Adaptations to Physical Activity

A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Endocrinology and Clinical Metabolic Research".

Deadline for manuscript submissions: closed (20 February 2025) | Viewed by 596

Special Issue Editors

Prof. Dr. Olga Scudiero

E-Mail Website
Guest Editor
Department of Molecular Medicine and Medical Biotechnology, University of Naples Federico II, 80131 Naples, Italy
Interests: physical activity; antimicrobial peptides
Special Issues, Collections and Topics in MDPI journals
Dr. Cristina Mennitti

E-Mail Website
Guest Editor
Department of Molecular Medicine and Medical Biotechnology, University of Naples Federico II, Naples, Italy
Interests: physical activity; antimicrobial peptides

Special Issue Information

Dear Colleagues,

The beneficial effects of physical activity are well known. In fact, regular physical activity is associated with a healthy lifestyle and the prevention of many disorders, such as cardiovascular disease, obesity, depression, anxiety, and stress. On the other hand, intense physical activity exposes athletes to an increased risk of thrombotic events and muscle injuries, and a higher sensitivity to infections.

In particular, moderate to intense physical activity generates considerable metabolic, endocrine, and bio-chemical changes, reflected in several biomarkers measurable in the laboratory. To date, the main mecha-nisms that determine these variations are largely unknown; their accurate identification could represent a valid tool to monitor the health status of athletes and protect them from damage and decreased fitness.

In this context, this Special Issue aims to identify changes in blood biomarkers during physical activity and to shed light on the interplay between exercise and the onset of disorders that can threaten the health of individuals practising it.

Dr. Olga Scudiero
Dr. Cristina Mennitti
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • physical activity
  • biomarkers
  • metabolic adaptations
  • exercise
  • performance
  • athletes

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Published Papers (1 paper)

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Research

15 pages, 554 KiB  
Article
Steroids Static Postural Balance Changes After Exercise Intervention Correlate with Steroidome in Elderly Female
by Zuzanna Kornatovská, Martin Hill, Dobroslava Jandová, Milada Krejčí and Anna Zwierzchowska
Metabolites 2025, 15(4), 239; https://doi.org/10.3390/metabo15040239 - 1 Apr 2025
Viewed by 274
Abstract
Background: Aging is associated with the development of various disorders, including postural imbalance, which increases the risk of falls and related health complications. This study examines changes in static postural balance after a 4-week intervention involving appropriate exercise and an optimized daily regimen. [...] Read more.
Background: Aging is associated with the development of various disorders, including postural imbalance, which increases the risk of falls and related health complications. This study examines changes in static postural balance after a 4-week intervention involving appropriate exercise and an optimized daily regimen. Additionally, it explores the relationship between these changes and the steroidome. Methods: The study was conducted on a clinically homogeneous group of 41 females around their sixth decade, diagnosed with anxiety-depressive syndrome and treated with selective serotonin reuptake inhibitors (SSRIs). Postural balance was assessed using the dual-scales method (DLLL-DSM), which estimates postural imbalance by evaluating differences in the lower limb load in the standing position. Correlations between initial DLLL-DSM values, age, BMI, and the baseline levels of nine serum steroids, as well as post-intervention changes in five steroids, were analyzed using multivariate regression (OPLS model). Results: A significant reduction in lower limb load differences (-ΔDLLL-DSM), indicating improved postural balance, was observed. The -ΔDLLL-DSM strongly correlated with initial DLLL-DSM values, age, BMI, initial levels of nine serum steroids, and post-intervention changes in five steroids (R = 0.892, p < 0.001). Furthermore, initial DLLL-DSM values negatively correlated with adrenal androgen androstenediol sulfate and various sulfated 5α/β-reduced androgen metabolites (R = 0.323, p < 0.05), suggesting that the activity of steroid sulfotransferase (SULT2A1) and C17-hydroxylase-C17,20-lyase (CYP17A1) at the lyase step is negatively associated with postural imbalance in elderly females. Conclusions: The findings suggest that even severe postural imbalance can be effectively and relatively rapidly improved through an appropriate exercise-based intervention and an optimized daily regimen, provided that initial adrenal activity is not significantly impaired. Additionally, the identified associations between steroid levels and postural balance provide new insights into the hormonal mechanisms regulating balance control in older individuals. Full article
(This article belongs to the Special Issue Interplay Between Metabolic Adaptations to Physical Activity)
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