Topic Editors

Department of Medicine, AFO Medicine Interna, PO Santa Maria delle Grazie Hospital, ASL Napoli 2 Nord, 80078 Napoli, Italy
UOC Emerging Infectious Disease with High Contagiousness, AORN Ospedali dei Colli P.O. C Cotugno, 80131 Naples, Italy
Department of Molecular Medicine and Medical Biotechnology, University of Naples Federico II, Naples, Italy

Bacterial Porins and Their Implication in Pathophysiology of Septic Complications In Vitro and In Vivo

Abstract submission deadline
30 November 2024
Manuscript submission deadline
31 January 2025
Viewed by
405

Topic Information

Dear Colleagues,

Bacterial porins control cellular interactions with host proteins and other circulating substances, such as drugs and nutrients. They may act as toxins, damaging different systems and organs in the host. For this reason, they play a fundamental role in the processes involved in drug resistance and bacterial-induced complications, such as thrombosis, bleeding, and septic shock. Our in vitro experience in the early 2000s showed that bacterial porin from salmonella is able to activate the clotting cascade with the direct activation of thrombin, explaining its frequent association with thrombosis and disseminated intravascular coagulation. Furthermore, resistance towards drugs other than antibiotics may also explain other types of complications, such as kidney or liver failure. Therefore, this multidisciplinary topic of Toxins is directed to scholars that are experts not only in the field of bacterial porins, but also in the clinical spectrum of their induced complications, such as septic shock, disseminated intravascular coagulation, thrombosis of small or large vessels, and kidney or liver failure.

Dr. Pierpaolo Di Micco
Dr. Alessandro Perrella
Dr. Olga Scudiero
Topic Editors

Keywords

  • porins
  • LPS
  • antibiotic resistance
  • antibiotic stewardship
  • septic shock
  • disseminated intravascular coagulation
  • liver toxicology
  • kidney dysfunction
  • clotting abnormalities

Participating Journals

Journal Name Impact Factor CiteScore Launched Year First Decision (median) APC
Antibiotics
antibiotics
4.3 7.3 2012 14.7 Days CHF 2900 Submit
Applied Microbiology
applmicrobiol
- - 2021 16.3 Days CHF 1000 Submit
Immuno
immuno
2.1 2.6 2021 28.1 Days CHF 1000 Submit
Medicina
medicina
2.4 3.3 1920 17.8 Days CHF 2200 Submit
Toxins
toxins
3.9 7.5 2009 18.9 Days CHF 2700 Submit

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