The Interface of Mitochondrial Genetics, Epigenetics and Energetics in Muscle Metabolism
A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Cell Metabolism".
Deadline for manuscript submissions: closed (31 May 2023) | Viewed by 1796
Special Issue Editor
Interests: metabolic myopathies; mitochondrial disorders; human genetics; clinical implication of diseases; neuromuscular disorders from a general medicine perspective
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
All cells, including muscle cells, consume energy to perform work. This energy is generated by metabolism of adenosine triphosphate (ATP) to adenosine diphosphate (ADP) and is funneled through bioenergetic systems such as glycolysis and mitochondrial oxidative phosphorylation (OXPHOS). The OXPHOS system is embedded inside the inner mitochondrial membrane, and it consists of five multiprotein complexes and two electron carriers. The individual subunits of the OXPHOS complexes are encoded either by mitochondrial DNA (mtDNA) or nuclear DNA (nDNA). Apart from that, a number of various bioenergetic genes are spread across chrosome and mtDNA. Hence, the epigenetic and genetic abnormalities within the mitochondria as well as within the chromosome tend to lead to abnormal mitochondrial bioenergetics, subsequently affecting the muscle metabolism. This is strengthened by the fact that an influence of epigenetic and genetic mechanisms on the normal functioning of various cellular activities, including mitochondrial bioenergetics, has been frequently reported. The growing interest of researchers in the interface of mtDNA epigenetic and genetic modifications and bioenergetics over the years has opened a broad new avenue into the interaction mechanisms between mitochondria and nucleus. Hence, the present Special Issue will focus on the reciprocal control of mitochondrial and nuclear epigenetic, genetic, and bioenergetic factors, focusing on the role of mitochondrial genome and metabolism in shaping epigenetic modulation of gene expression and subsequent muscle metabolism dysfunction.
In this Special Issue entitled “The interface of Mitochondrial Genetics, Epigenetics, and Energetics in Muscle Metabolism”, submissions of original scientific reports, review articles, case reports, and perspective pieces on the role of mitochondrial modification on muscle metabolism are invited. Hence, this issue will cover the diverse genetic, epigenetic, as well as bioenergetic aspects of mitochondrial myopathies leading to abnormal muscle metabolism.
There is no doubt that this Special Issue will be an incredible resource for scientists working within the field of mitochondrial myopathies as well as for life science researchers in general.
Dr. Pushpa Raj Joshi
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- cell metabolism mtDNA mutation
- large-scale deletions
- metabolism
- oxidative stress
- oxidative phosphorylation
- metabolic disorders
- multi-systemic disorders
- isolated myopathy
- neurological disorders
- mitochondria-targeting therapy
