Special Issue "Mass Spectrometry: Recent Advancements in In Situ Metabolomics"

A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Metabolomic Profiling Technology".

Deadline for manuscript submissions: 15 June 2022.

Special Issue Editor

Dr. Mike Taylor
E-Mail Website
Guest Editor
The Pacific Northwest National Laboratory, 902 Battelle Blvd, Richland, WA 99354, USA
Interests: in situ; spatial-omics; metabolomics; mass spectrometry imaging; multimodal imaging; single-cell; surface analysis

Special Issue Information

Dear Colleagues,

Over the past decade, metabolomics has advanced to the point where a variety of targeted and untargeted methods are available for characterization of the metabolome.
In situ metabolomics involves the removal, ionization, extraction, and identification of metabolites in tissue or cultures. There are now a variety of tools available for in situ metabolomics including liquid extraction surface analysis (LESA), matrix-assisted laser desorption/ionization (MALDI), and secondary ion  mass spectrometry (SIMS).
Increasingly, these modalities are being adapted to sample at smaller scales, with increased spatial resolutions, improved sensitivity, and better capability to assign structure through orthogonal methods. For example, many in situ methods can now be applied to decipher metabolic profiles at the single cell scale with femtomolar sensitivities.
This Special Issue on “Recent Advancements in In Situ Metabolomics” is devoted to analytical methods that employ in situ mass spectrometry sampling methods for metabolomics.

Papers are invited which address sample preparation, application of new and available sampling modes, data analysis strategies, and any aspects of in situ metabolomics which improve workflows. We also invite manuscripts dealing with other pertinent challenging issues including automated (high-throughput) approaches toward metabolite extraction and identification, novel data processing methods, and metabolite annotation pipelines. Reviews and perspectives of the challenges of in situ metabolomics are also welcomed.


Dr. Mike Taylor
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • in situ metabolomics
  • spatial-omics
  • sample preparation
  • mass spectrometry imaging/ imaging mass spectrometry
  • single-cell metabolomics
  • reviews and perspectives

Published Papers

This special issue is now open for submission.
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