Hearing Loss and Metabolism

A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Integrative Metabolomics".

Deadline for manuscript submissions: closed (15 September 2022) | Viewed by 2537

Special Issue Editors


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Guest Editor
1. Biochemistry Department, Tours University Hospital, 37000 Tours, France
2. INSERM 1253, iBrain, University of Tours, Inserm, 37000 Tours, France
Interests: metabolomic analysis, amyotrophic lateral sclerosis; biomarkers
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
1. INSERM 1253, iBrain, University of Tours, Inserm, 37000 Tours, France
2. House Institute Foundation, Los Angeles, CA 90057, USA
3. ENT department, Tours University Hospital, 37000 Tours, France
Interests: hearing loss; biomarkers; pathophysiology; inner ear; auditory rehablitatin

Special Issue Information

Dear Colleagues,

Deafness is the most common sensory deficit. It affects 5.5% of the world's population, with important consequences in daily life. Indeed, the difficulties can range from a delay in the acquisition of oral language in children, to difficulty in oral communication in adults to real social isolation or even depression. The pathophysiological mechanisms leading to deafness are poorly understood, and no biomarkers have been identified in relation to the etiology and/or duration of deafness which are important prognostic factors for the outcome of hearing rehabilitation. The emergence of metabolomics could allow a better understanding of the pathophysiological mechanisms, to identify biomarkers and to propose personalized treatments. This Special Issue of Metabolites titled " Hearing Loss and Ear Fluid Metabolism " is dedicated to metabolomics research on fluid and tissue analysis in ear pathologies. Topics covered in this Issue include sampling and analysis techniques, biomarker identification, improvement of pathophysiological knowledge, data processing and the development of personalized treatment.

Prof. Dr. Helene Blasco
Prof. Dr. David Bakhos
Guest Editors

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Keywords

  • Ear
  • Hearing loss
  • Biomarkers
  • Metabolites
  • Metabolism

Published Papers (1 paper)

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12 pages, 772 KiB  
Systematic Review
Metabolomic Studies in Inner Ear Pathologies
by Luc Boullaud, Hélène Blasco, Thuy-Trân Trinh and David Bakhos
Metabolites 2022, 12(3), 214; https://doi.org/10.3390/metabo12030214 - 26 Feb 2022
Cited by 5 | Viewed by 2000
Abstract
Sensorineural hearing loss is the most common sensory deficit. The etiologies of sensorineural hearing loss have been described and can be congenital or acquired. For congenital non-syndromic hearing loss, mutations that are related to sites of cochlear damage have been discovered (e.g., connexin [...] Read more.
Sensorineural hearing loss is the most common sensory deficit. The etiologies of sensorineural hearing loss have been described and can be congenital or acquired. For congenital non-syndromic hearing loss, mutations that are related to sites of cochlear damage have been discovered (e.g., connexin proteins, mitochondrial genes, etc.). For cytomegalovirus infection or auditory neuropathies, mechanisms are also well known and well researched. Although the etiologies of sensorineural hearing loss may be evident for some patients, the damaged sites and pathological mechanisms remain unclear for patients with progressive post-lingual hearing loss. Metabolomics is an emerging technique in which all metabolites present in a sample at a given time are analyzed, reflecting a physiological state. The objective of this study was to review the literature on the use of metabolomics in hearing loss. The findings of this review suggest that metabolomic studies may help to develop objective tests for diagnosis and personalized treatment. Full article
(This article belongs to the Special Issue Hearing Loss and Metabolism)
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