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Metabolites
Special Issues
Human Reproductive Health and Metabolism
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Human Reproductive Health and Metabolism

A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Endocrinology and Clinical Metabolic Research".

Deadline for manuscript submissions: closed (15 May 2022) | Viewed by 9458

Special Issue Editors

Prof. Dr. Maria Antonietta Castiglione-Morelli

E-Mail Website
Guest Editor
Department of Sciences, University of Basilicata, 85100 Potenza, Italy
Interests: biochemistry; structural biology; NMR; metabolomics; metabolism
Dr. Angela Ostuni

E-Mail Website
Guest Editor
Department of Sciences, University of Basilicata, 85100 Potenza, Italy
Interests: cell biology; biochemistry; biomarkers; transcriptome; cancer; ABC transporters; metabolism; recombinant proteins
Special Issues, Collections and Topics in MDPI journals
Dr. Assunta Iuliano

E-Mail Website
Guest Editor
Center for Reproductive Medicine of San Carlo Hospital, Potenza, Italy
Interests: pathophysiology of human reproduction; assisted reproductive technology; fertility-sparing

Special Issue Information

Dear Colleagues,

We welcome the submission of original research articles or review papers as contributions to this Special Issue of Metabolites dedicated to “Human Reproductive Health and Metabolism”. The aim of the issue is to highlight all the connections between human reproductive health and metabolism, with a particular focus on reproductive disorders linked to metabolic dysfunctions. This includes the identification of characteristic biomarkers of disease states; the application of metabolomics for diagnosis and prognosis of infertility diseases; and the understanding of the cellular and biological mechanisms involved in fertility. Manuscripts addressing other questions on metabolism relevant to the topic of human reproductive health are also welcome.

Prof. Dr. Maria Antonietta Castiglione-Morelli
Dr. Angela Ostuni
Dr. Assunta Iuliano
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • human reproduction
  • infertility disorders
  • assisted reproductive techniques
  • pregnancy
  • biomarkers
  • metabolites
  • metabolomics

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Published Papers (2 papers)

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Research

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11 pages, 278 KiB  
Article
Triglycerides/Glucose Index Is Associated with Sperm Parameters and Sperm DNA Fragmentation in Primary Infertile Men: A Cross-Sectional Study
by Federico Belladelli, Luca Boeri, Edoardo Pozzi, Giuseppe Fallara, Christian Corsini, Luigi Candela, Walter Cazzaniga, Daniele Cignoli, Luca Pagliardini, Alessia D’Arma, Paolo Capogrosso, Eugenio Ventimiglia, Francesco Montorsi and Andrea Salonia
Metabolites 2022, 12(2), 143; https://doi.org/10.3390/metabo12020143 - 3 Feb 2022
Cited by 19 | Viewed by 3076
Abstract
Study question: we aimed to investigate the relationship between the tyg index and both semen and hormonal characteristics in a cohort of primary infertile men. Summary answer: almost one in two primary infertile men presented with a triglycerides/glucose index (tyg) suggestive of insulin [...] Read more.
Study question: we aimed to investigate the relationship between the tyg index and both semen and hormonal characteristics in a cohort of primary infertile men. Summary answer: almost one in two primary infertile men presented with a triglycerides/glucose index (tyg) suggestive of insulin resistance (ir). overall, patients with tyg suggestive of ir showed worse clinical, hormonal, and semen parameters. What is already known: male factor infertility (MFI) is often associated with metabolic disorders such as diabetes mellitus and metabolic syndrome, where insulin resistance (IR) plays a relevant pathological role. Recently, TyG has been suggested as a user-friendly IR marker. Study Design: serum hormones and the sperm DNA fragmentation index (SDF) were measured in every patient. The semen analysis was based on 2010 WHO reference criteria. Glucose and insulin levels were measured for every man after a 12-h overnight fast, and the homeostatic model assessment index (HOMA-IR) was then calculated and categorized using a 2.6 threshold. Similarly, fasting glucose and triglycerides levels were measured and the TyG index was calculated and categorized using an 8.1 threshold. Descriptive statistics and logistic regression models tested the association between the TyG and semen and hormonal characteristics. Participants: complete demographic, clinical, and laboratory data from 726 consecutive white European primary infertile men were considered for this analysis. Main results and the role of chance: the median (IQR) age was 39 (35–43) years. A TyG and HOMA suggestive for IR was found in 339 (46.6%) and 154 (21.2%) men, respectively. During the Spearman’s test, the TyG index was highly correlated with HOMA-IR (rho = 0.46, p < 0.001). Compared to men with a normal TyG, men with TyG > 8.1 were older, had greater BMI and CCI scores, and lower total testosterone and sperm concentration, but higher DFI, and presented a greater proportion of NOA (all p < 0.01). The multivariable logistic regression analysis showed that men with TyG > 8.1 were at higher risk of SDF > 30 (OR 1.92 (CI: 1.2–2.9)) and NOA (OR 1.78 (CI: 1.1–2.8)). Wider implications of the findings: the Tyng index may act as a reliable marker of IR in the clinical work-up of primary infertile men in real-life settings. Full article
(This article belongs to the Special Issue Human Reproductive Health and Metabolism)

Review

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10 pages, 241 KiB  
Review
The Impact of Mineral Supplementation on Polycystic Ovarian Syndrome
by Tahra ElObeid, Marwa Osman Awad, Vijay Ganji and Joyce Moawad
Metabolites 2022, 12(4), 338; https://doi.org/10.3390/metabo12040338 - 8 Apr 2022
Cited by 10 | Viewed by 5552
Abstract
Polycystic ovary syndrome (PCOS) is an endocrinopathy that is common among women of reproductive age. It is a heterogeneous disorder with an unknown etiology. Different strategies have been proposed for the treatment of PCOS. Recent studies recommend supplementation with specific minerals for treating [...] Read more.
Polycystic ovary syndrome (PCOS) is an endocrinopathy that is common among women of reproductive age. It is a heterogeneous disorder with an unknown etiology. Different strategies have been proposed for the treatment of PCOS. Recent studies recommend supplementation with specific minerals for treating various PCOS phenotypes. We searched PubMed, Google Scholar, and SCOPUS databases by using search terms combining PCOS with the supplementation of magnesium, zinc, selenium, or chromium. This review presents a narrative concerning the association between PCOS and magnesium, zinc, selenium, and chromium supplementation. We review findings from various randomized controlled trials and meta-analyses conducted in women of childbearing age with PCOS. Recent reports highlight the beneficial effect of minerals on the clinical and metabolic symptoms of PCOS. Further studies are required to establish the appropriate dosage level of these minerals for ameliorating the pathologies associated with PCOS because of the potential health risks linked with higher doses. Full article
(This article belongs to the Special Issue Human Reproductive Health and Metabolism)
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