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Special Issue "Application of Metabolomics in Toxicology Research"
A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Pharmacology and Drug Metabolism".
Deadline for manuscript submissions: closed (15 January 2023) | Viewed by 6747
Special Issue Editors
Interests: toxicological analysis; metabolites; forensics
Interests: enzyme kinetics; toxicology; pharmacokinetics; LC-MS/MS; MDMA; postmortem analytical considerations for (un)‐targeted metabolomic studies with special focus on forensic applications
Special Issue Information
Toxicology has faced many challenges for many years, both concerning the analytical detection of drugs in relation to the ever-increasing potential drugs of interest, and concerning the final interpretation of the toxicological result. The development of highly sensitive detection techniques and appropriate data processing has enabled this progress. About a decade ago, metabolomics was introduced into the fields of forensic, clinical and environmental toxicology. The increasing use of metabolomic studies can identify changes between different states (e.g., toxic versus non-toxic), leading to the potential identification of more suitable biomarkers of toxicity. Another interesting aspect of metabolomics is the possibility of detecting biomarkers for interpretation concerning the state of the samples themselves (e.g., determination of PM interval, the impact of storage, adulteration). Moreover, mapping of the biochemical changes after drug use can lead to the detection of new metabolites in a time- and dose-dependent manner, and could result in knowledge concerning the pharmacodynamic targets and differences in acute versus long-term use.
The purpose of this Special Issue is to look into the current metabolomic research that is done in the context of forensic, clinical or environmental toxicology. The aim is to give an overview of what is yet possible and what can be expected towards the future concerning new biomarkers for drug detection and interpretation. The purpose is to be informative for toxicologists dealing with case work (forensic, clinical and environmental), but also for more fundamental scientists looking to improve their research whilst investigating the opportunities of metabolomics for better evidence-based toxicological solutions.
Dr. Sarah Wille
Dr. Andrea E. Steuer
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- forensic toxicology
- clinical toxicology
- environmental toxicology