Dear Colleagues,

The capability of the organism to respond or adapt metabolism to substrate availability, modulating its storage, trafficking, and utilization, is called metabolic flexibility. An example is the ability to select fuels between glucose and fatty acids. Insulin resistance leads to metabolic inflexibility in type 2 diabetes and obesity. Metabolic flexibility also relies on organs’ interplay since the liver, adipose tissue, and muscle regulate energy homeostasis in a coordinated fashion depending on the caloric intake and energy demand. Metabolic inflexibility and the associated alterations in the metabolism of fatty acids are related to a variety of pathologies, such as an accumulation of triglycerides within hepatocytes, leading to a clinical condition known as nonalcoholic fatty liver disease, and changes in the lipid composition or in the regulation of noncoding RNAs related to lipid metabolism in cancer cells. This Special Issue highlights the importance of the metabolism of fatty acids in health and disease. Specific areas include metabolic flexibility and fatty acid metabolism, fuel supply and muscle adaptation during the life span, and metabolic integration of fatty acid metabolism and disease, including situations such as catch-up growth, nonalcoholic fatty acid liver disease, diabetes, obesity, cancer or inflammation. Manuscripts dealing with other pertinent challenging issues are also highly desired.

Prof. Dr. Maria D. Giron-Gonzalez
Dr. Jose M. López-Pedrosa
Prof. Dr. Rafael Salto-Gonzalez
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• Metabolic flexibility and fatty acid metabolism
• Fuel Supply and muscle adaptation during the life span
• Metabolic integration of fatty acid metabolism and disease
• Catch up growth and fatty acid metabolism
• Nonalcoholic fatty acid liver disease
• Diabetes and fatty acid metabolism
• Cancer and fatty acid metabolism
• Inflammation and fatty acid metabolism