Lipid Metabolism and Atherosclerosis: Cell Specific Functions and Molecular Mechanism of the Disease

A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Lipid Metabolism".

Deadline for manuscript submissions: 20 February 2025 | Viewed by 57

Special Issue Editor

E-Mail Website
Guest Editor
Department of Comparative Medicine, Yale University School of Medicine, New Haven, CT, USA
Interests: lipid metabolism; cardiometabolic diseases; liver disease; inflammation

Special Issue Information

Dear Colleagues,

Atherosclerosis stands as the leading cause of death and disability globally, primarily regarded as a chronic inflammatory disease of the arterial wall. This condition arises from a combination of imbalanced lipid metabolism and inflammatory responses. The well-established connection between circulating lipoproteins, particularly low-density lipoproteins (LDLs), and monocyte-derived macrophages as key drivers of inflammation in atherosclerosis has been extensively studied over the years. However, recent research has expanded our understanding of the complex mechanisms underlying macrophage inflammatory responses by examining the roles of other lipids and sterols.

Additionally, increasing evidence highlights the significant contributions of various arterial wall cells, including endothelial cells and smooth muscle cells, in the initiation and progression of atherosclerosis. These cells are capable of taking and processing circulating lipids, further contributing to the inflammatory responses within the arterial wall. This Special Issue aims to provide new insights into the roles of different aortic cell types and their contributions to lipid metabolism, inflammation, and the initiation and progression of atherosclerosis.

We invite the submission of scientific contributions focused on lipid dysregulation and inflammation and their consequences in cardiovascular disease and associated cardiometabolic disorders. While original research articles are highly encouraged, we also welcome review articles that comprehensively cover this topic.

Dr. Pablo Fernández-Tussy
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • lipid metabolism
  • lipoproteins
  • atherosclerosis
  • cardiovascular disease
  • macrophages
  • vascular smooth muscle cells
  • endothelial cells

Published Papers

This special issue is now open for submission.
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