The Factors Governing Cell Fate and Metabolism

Dear Colleagues,

A fundamental goal of stem cell and developmental biology is to understand the mechanisms controlling cell fate decisions. Indeed, the development and regeneration of tissues rely on the proper fate commitment of stem cells. Cell fate is tightly regulated by a dynamic interplay between extrinsic and intrinsic factors. Every cell type has distinct metabolic demands related to their function and fate change is often accompanied by a metabolic switch. Recently, it has emerged that metabolism is not merely a consequence of cell fate changes, but is an important driver of cell fate decisions and lineage specification.

In this Special Issue, we welcome original research articles and reviews providing new insights into the factors that can control fate determination and in particular the role of metabolism and metabolites in cell fate decisions. This Special Issue will contribute to a better understanding of the role of metabolic changes in stem cell differentiation during normal organism development and in diseases.

Potential topics include but are not limited to the following:

• Metabolomics analysis and the influence of metabolites on cell fate.
• The involvement of organelles such as lysosomes and mitochondria in the metabolic regulation of cell fate.
• Cell signaling regulators of metabolic state and fate decisions.
• The impact of metabolism on cell fate in in vitro and in vivo models, including model organisms, rodents, and cells in 2D or 3D cultures.
• The actors governing metabolic switches in pluripotent stem cells stages (naïve/primed PSC) and adult stem cells, as well as during reprogramming, direct differentiation and trans-differentiation.
• The consequences of metabolic perturbations on cell fate in aging and in diseases such as obesity, degenerative disease, and cancer.

We are looking forward to your contribution to this Special Issue.

Dr. Julie Mathieu
Guest Editor

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