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Metabolites
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Metabolic, Structural and Functional Alterations in Patients with Atrophic Diseases...
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Metabolic, Structural and Functional Alterations in Patients with Atrophic Diseases of the Retina

A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Cell Metabolism".

Deadline for manuscript submissions: closed (31 August 2022) | Viewed by 2888

Special Issue Editor

Dr. Margarita G. Todorova

E-Mail Website
Guest Editor
1. Department of Ophthalmology, Cantonal Hospital, 9007 St. Gallen, Switzerland
2. Department of Ophthalmology, University of Zürich, 8091 Zürich, Switzerland
3. Department of Ophthalmology, University of Basel, 4056 Basel, Switzerland
Interests: inherited diseases of the retina; retinal vessel oximetry; retinal vessel analysis; electrophysiology; diagnostics

Special Issue Information

Normal structural and functional integrity of all retinal layers are required in order to maintain proper retinal function. Comparable with the human brain, the retina is known to share the highest metabolic exchange in the body. Oxygen is known to be the most supplied metabolite in the retina, and regulation of adequate oxygen supply and cellular energy metabolism is required to maintain healthy retinal function. This regulation is especially critical to the photoreceptors, ganglion cells and their axons, where energy consumption is highly dynamic.

This Special issue focuses on investigating the effect of retinal structural and functional alterations on metabolic function in atrophic diseases of the retina.

 

Dr. Margarita G. Todorova
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • oxygen saturation
  • metabolic function of the retina
  • structure
  • function
  • blood supply
  • atrophic diseases of the retina
  • age-related macular degeneration
  • glaucoma

Published Papers (2 papers)

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Research

11 pages, 2846 KiB  
Article
Non-Invasive Metabolic and Structural Retinal Markers in Patients with Giant Cell Arteritis and Polymyalgia Rheumatica: A Cross-Sectional Study
by Simon J. Lowater, Torkell J. Ellingsen, Jens K. Pedersen, Jimmi Wied, Jakob Grauslund and Keld-Erik Byg
Metabolites 2022, 12(9), 872; https://doi.org/10.3390/metabo12090872 - 16 Sep 2022
Viewed by 1215
Abstract
Giant cell arteritis (GCA) is a potential sight-threatening disease. Although it is associated with polymyalgia rheumatica (PMR), visual loss is not common in PMR. A retinal oximeter can be used to conduct a direct, non-invasive, in vivo assessment of the vascular system. In [...] Read more.
Giant cell arteritis (GCA) is a potential sight-threatening disease. Although it is associated with polymyalgia rheumatica (PMR), visual loss is not common in PMR. A retinal oximeter can be used to conduct a direct, non-invasive, in vivo assessment of the vascular system. In a cross-sectional study, we measured the retinal oxygen saturation and retinal vessel calibers in GCA patients, PMR patients, and control participants. Twenty GCA patients (38 eyes), 19 PMR patients (33 eyes), and 12 controls (20 eyes) were investigated. Images were analyzed using Oxymap Analyzer software 2.5.0 (Oxymap ehf., Reykjavik, Iceland). Groups were compared using an age- and sex-adjusted linear mixed model regression. The median (IQR) age for GCA patients was 69.0 (66.5–76.5) years, for PMR 69.0 (67.0–72.0) years, and for the controls 75.5 (71.5–81.0) years, respectively. As compared to the controls (115.3 µm), the retinal arterioles were significantly wider in patients with GCA (124.4 µm; p = 0.023) and PMR (124.8 µm; p = 0.049). No difference was found in the retinal venular caliber or vascular oxygen saturation. These results indicate that GCA and PMR patients differ similarly in the retinal arteriolar diameter compared to controls. Further studies are needed in order to clarify the underlying inflammatory mechanisms in retinal arteriolar vessels and if these parameters can be used to predict clinical outcomes. Full article
(This article belongs to the Special Issue Metabolic, Structural and Functional Alterations in Patients with Atrophic Diseases of the Retina)
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15 pages, 937 KiB  
Article
Peripapillary Oxygenation and Retinal Vascular Responsiveness to Flicker Light in Primary Open Angle Glaucoma
by Cengiz Türksever and Margarita G. Todorova
Metabolites 2022, 12(7), 597; https://doi.org/10.3390/metabo12070597 - 27 Jun 2022
Cited by 4 | Viewed by 1258
Abstract
The aim of our study was to evaluate peripapillary oxygenation and its relationship to retinal vascular responsiveness to flicker light in patients with primary open angle glaucoma (POAG). Retinal vessel oxygen saturation was measured in 46 eyes of 34 Caucasian patients with POAG [...] Read more.
The aim of our study was to evaluate peripapillary oxygenation and its relationship to retinal vascular responsiveness to flicker light in patients with primary open angle glaucoma (POAG). Retinal vessel oxygen saturation was measured in 46 eyes of 34 Caucasian patients with POAG and in 21 eyes of 17 age-matched controls using the oximetry tool of Retinal Vessel Analyser (RVA: IMEDOS Systems UG, Jena, Germany). The mean oxygen saturation of the major arterioles (A-SO2; %) and venules (V-SO2; %), as well as the corresponding arterio–venular difference (A-V SO2; %), were calculated. We also measured retinal vascular responsiveness (RVR) to flicker light by means of RVA. Glaucoma patients were divided in two subgroups according to their median arteriolar and venular vascular responsiveness to flicker light (AFR and VFR). Glaucomatous damage was assessed by optical coherence tomography (Carl Zeiss Meditec, Dublin, CA, USA) and static automated perimetry (Octopus, program G2/standard strategy: Haag-Streit International, Köniz, Switzerland). In addition, we calculated the mean peripapillary oxygen exposure [ppO2E; %/µm] by dividing the mean A-V SO2 with the mean retinal nerve fibre layer (RNFL) thickness. In glaucoma patients, A-SO2 and V-SO2 values were significantly increased, and their difference decreased when compared to controls (p < 0.017; linear mixed-effects model). Grouped with respect to retinal vascular responsiveness to flicker light, subjects with reduced VFR (≤2.9%) had significantly higher ppO2E (0.49 ± 0.08%/µm, respectively, 0.43 ± 0.06%/µm; p = 0.027). Additionally, higher ppO2E in glaucoma patients correlated negatively with the neuroretinal rim area (p < 0.001) and the RNFL thickness (p = 0.017), and positively with the mean defect of the visual field (p = 0.012). Reduced venular vascular responsiveness in our glaucoma patients was associated with increased peripapillary oxygenation exposure. Thus, ganglion cells and their axons in glaucomatous eyes with reduced retinal vascular responsiveness are prone to be more exposed to higher oxidative stress, probably contributing to the further progression of glaucomatous damage. Full article
(This article belongs to the Special Issue Metabolic, Structural and Functional Alterations in Patients with Atrophic Diseases of the Retina)
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