Metabolic Dysregulation in Fatty Liver Disease
A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Endocrinology and Clinical Metabolic Research".
Deadline for manuscript submissions: 30 June 2025 | Viewed by 946
Special Issue Editors
Interests: metabolomics; omics-integration; gut microbiota; metabolic diseases; molecular nutrition
Interests: prostanoid; G protein-coupled receptor; nuclear receptor; hypertension; non-alcoholic fatty liver disease; diabetes; acute renal injury; chronic kidney disease
Special Issue Information
Dear Colleagues,
Fatty liver disease (FLD) is a growing global health crisis, associated with high morbidity, mortality, and significant economic burden. It is characterized by the accumulation of fat in the liver cells, primarily due to metabolic dysfunction. Key risk factors for FLD include excessive alcohol consumption, obesity, diabetes, hepatitis C infection, hormonal imbalances, certain surgeries, medications, and genetic polymorphisms (such as PNPLA3 and TM6SF2). The disease is driven by insulin resistance, oxidative stress, and inflammation, leading to disrupted lipid and glucose metabolism. Despite its increasing prevalence, FLD has not received the attention that other related conditions, such as diabetes and obesity, have garnered.
Recent advancements in metabolomics have provided new insights into the complex metabolic pathways involved in FLD. These studies highlight the critical role of metabolites in interorgan communication and systemic metabolic regulation. This Special Issue focuses on the metabolic dysregulation underlying FLD and explores the disease’s connections to other metabolic disorders. By bringing together multidisciplinary research, the Issue aims to advance the molecular understanding of FLD, identify novel biomarkers, and uncover new therapeutic targets.
This collection offers valuable insights for researchers, clinicians, and public health experts interested in the far-reaching impacts of metabolic dysregulation in FLD, while also pointing towards promising strategies for prevention and treatment.
Dr. Ambrin Farizah Babu
Prof. Dr. Youfei Guan
Guest Editors
Manuscript Submission Information
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Keywords
- metabolic dysregulation
- metabolic homeostasis
- insulin resistance
- oxidative stress
- lipid metabolism
- glucose metabolism
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