Special Issue "Mass Spectrometry in Metabolomics"

A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Metabolomic Profiling Technology".

Deadline for manuscript submissions: 31 July 2023 | Viewed by 851

Special Issue Editor

Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
Interests: clinical biomarkers; proteomics; metabolomics; lipidomics; diagnosis
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Metabolism is the chemical process that occurs in cells and living organisms to produce substances and energy needed to sustain life. Metabolomics focuses primarily on small molecular metabolites. The metabolome is considered to be more phenotypic than the genome because metabolites are variable depending on disease and environment. However, we do not know what and how many metabolites are present in the cell. Metabolomics deals with compounds that are widely different in their physicochemical properties. Advances in mass spectrometry have made it possible to measure a large number of metabolites. Even so, it is not possible to obtain the whole picture in a single analysis. There are many challenges in mass spectrometry, such as the certainty of metabolite identification and precise control of quantitative data. However, mass spectrometry has revealed many biological phenomena through metabolomics. In this Special Issue, we will discuss the latest information on metabolomics via mass spectrometry.

Prof. Dr. Yoshiya Oda
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • mass spectrometry
  • sample preparation
  • chromatography
  • identification
  • quantitation
  • comprehensiveness
  • high- throughput
  • pathway
  • biological function
  • disease

Published Papers (1 paper)

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Research

Article
Lipidomic Analysis of Hand Skin Surface Lipids Reveals Smoking-Related Skin Changes
Metabolites 2023, 13(2), 254; https://doi.org/10.3390/metabo13020254 - 09 Feb 2023
Viewed by 653
Abstract
Smoking contributes to the formation of skin wrinkles and reduces skin function, but the mechanism is not yet fully proven. This study aims to compare and analyze the effects of smoking on skin lipids and to further investigate the harmful effects of smoking [...] Read more.
Smoking contributes to the formation of skin wrinkles and reduces skin function, but the mechanism is not yet fully proven. This study aims to compare and analyze the effects of smoking on skin lipids and to further investigate the harmful effects of smoking on the skin. A total of 40 subjects (20 male smokers and 20 healthy control males) were recruited for this study. Measurement of hand skin-surface lipids (SSLs) in smoking and healthy control groups was undertaken using ultra-performance liquid chromatography quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF-MS). Multivariate data analysis was used to investigate the differences in SSLs between the two groups. There were 1230 lipids detected in the two groups and significant differences in SSLs’ composition were observed between them. Under selected conditions, 26 types of lipid with significant differences were observed between the two groups (p < 0.05). Sphingolipids (SP) and glycerolipids (GL) were significantly increased, and sterol lipids (ST) were significantly reduced. Smoking causes changes in skin lipids that disrupt skin homeostasis, making the skin more fragile and more susceptible to skin aging and diseases. Full article
(This article belongs to the Special Issue Mass Spectrometry in Metabolomics)
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