Advances in Cholesterol and Lipid Metabolism II
A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Lipid Metabolism".
Deadline for manuscript submissions: closed (30 April 2023) | Viewed by 7174
Special Issue Editors
Interests: cholesterol metabolism; cardiovascular; atherosclerosis; inflammation
Special Issues, Collections and Topics in MDPI journals
2. Division of Cardiology, Department of Medicine, NYU Long Island School of Medicine, Mineola, NY 11501, USA
Interests: inflammation; lipids; cardio-neurologic axis
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Lipid metabolism plays a key role in the development of atherosclerotic cardiovascular disease (ASCVD) and is linked to pathological processes including obesity, diabetes and a number of neurologic disorders. In ASCVD, cholesterol, an essential cell membrane component, accumulates in the arterial wall. LDL is the main carrier of circulating cholesterol within the body and, when oxidatively modified, is highly atherogenic. Atheroprotective removal of cholesterol is predominantly via HDL-mediated reverse cholesterol transport. Approximately 40–65% of persons with Alzheimer’s disease carry the ApolipoproteinE-ε4 haplotype. In the last decade, our understanding of pathological mechanisms in disordered lipid metabolism has led to new biomarkers and drug treatments such as PCSK9 inhibitors for hypercholesterolemia. Recent progress in understanding biological pathways that influence lipid metabolism has implications in improving lifespan and quality of life for persons with ASCVD and other disorders.
For this Special Issue of Metabolites, we invite original research articles and reviews focused on developments in cholesterol and lipid metabolism highlighting how our evolving knowledge impacts treatment approaches to cardiovascular and neurologic disorders. We are particularly interested in the role of microRNAs, extracellular vesicles, complex signaling pathways and immune/inflammatory mechanisms in regulating lipid homeostasis in the cardiovascular and nervous systems.
Dr. Allison B Reiss
Dr. Joshua De Leon
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- cholesterol
- lipids
- atherosclerosis
- neurodegeneration
- apolipoproteins
- myocardial infarction
- stroke
- Alzheimer’s disease
- microRNA
- dyslipidemia
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