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Metabolites
Special Issues
Obesity, Hormones, and Metabolic Complications in Pregnancy
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Obesity, Hormones, and Metabolic Complications in Pregnancy

A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Endocrinology and Clinical Metabolic Research".

Deadline for manuscript submissions: 15 June 2026 | Viewed by 272

Special Issue Editors

Dr. Angélica Saraí Jiménez-Osorio

E-Mail Website
Guest Editor
Área Académica de Enfermería, Instituto de Ciencias de la Salud, Universidad Au-tónoma del Estado de Hidalgo, Circuito Actopan Tilcuautla s/n, Ex Hacienda La Concepción, San Agustín Tlaxiaca 42160, Hidalgo, Mexico
Interests: obesity; childhood obesity; pregnancy; neonatal health; oxidative stress; inflammation; cardiometabolic diseases
Dr. Diego Estrada-Luna

E-Mail Website
Guest Editor
Área Académica de Enfermería, Instituto de Ciencias de la Salud, Universidad Au-tónoma del Estado de Hidalgo, Circuito Actopan Tilcuautla s/n, Ex Hacienda La Concepción, San Agustín Tlaxiaca 42160, Hidalgo, Mexico
Interests: obesity; bioactive compounds; lipid metabolism; oxidative stress; inflammation; cardiovascular diseases; high-density lipoproteins
Prof. Dr. Jennifer W. Hill

E-Mail Website
Guest Editor
Center for Diabetes and Endocrine Research, College of Medicine, The University of Toledo, Toledo, OH 43614, USA
Interests: neuroendocrinology; fertility; reproduction; insulin; leptin; hypothalamus; POMC; AgRP; obesity; mice
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Obesity remains a pressing global health concern, posing significant challenges to healthcare systems worldwide. Pre-pregnancy obesity and gestational weight gain are critical factors that play a pivotal role in modulating hormonal changes, thereby compromising gestational health. The activation of signaling pathways due to hormonal dysregulation can exacerbate oxidative stress, inflammation, and metabolic complications during pregnancy. Furthermore, gestational complications can have a profound impact on the health of the newborn and the development of childhood obesity and related diseases.

This Special Issue will publish studies focused on obesity during pregnancy, gestational weight gain, hormonal involvement, the mechanisms behind oxidative stress and inflammation, the development of metabolic disease during pregnancy, and effects on newborn health, neonatal complications, and childhood health. Additionally, studies on prenatal exposure and adolescent diseases are welcome.

Dr. Angélica Saraí Jiménez-Osorio
Dr. Diego Estrada-Luna
Prof. Dr. Jennifer W. Hill
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • obesity
  • gestational weight gain
  • hormones
  • oxidative stress
  • inflammation
  • metabolic complications of pregnancy
  • neonatal complications
  • childhood health

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Published Papers (2 papers)

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Research

15 pages, 1294 KB  
Article
From BIA to BMI: A New Look at Postpartum Recovery and Breastfeeding Outcomes
by Dominika Mazur, Kornelia Purc-Bandurko, Żaneta Kimber-Trojnar, Marcin Trojnar and Bożena Leszczyńska-Gorzelak
Metabolites 2026, 16(1), 23; https://doi.org/10.3390/metabo16010023 (registering DOI) - 25 Dec 2025
Abstract
Background/Objectives: Successful and sustained breastfeeding depends on maternal, psychological, metabolic and obstetric factors including hydration status, body composition, gestational age at delivery and mode of delivery, which are rarely assessed together in routine postpartum care. Bioelectrical impedance analysis (BIA) provides a non-invasive assessment [...] Read more.
Background/Objectives: Successful and sustained breastfeeding depends on maternal, psychological, metabolic and obstetric factors including hydration status, body composition, gestational age at delivery and mode of delivery, which are rarely assessed together in routine postpartum care. Bioelectrical impedance analysis (BIA) provides a non-invasive assessment of hydration and tissue composition, yet its potential to support lactation outcomes remains insufficiently studied. This study aimed to evaluate the relationship between postpartum body composition, hydration status assessed with BIA, and breastfeeding duration. Methods: A total of 122 women in the early postpartum period after term singleton deliveries were enrolled, of whom 50 completed the full protocol, including a 7-month follow-up. BIA and anthropometric measurements were performed on postpartum days 2 and 3. Breastfeeding duration was assessed at 7 months via telephone interview and categorized as <6 months or ≥6 months. Two indices (PLBI and sPLBI) were calculated to describe BMI change from pre-pregnancy to 7 months postpartum. Results: Breastfeeding for ≥6 months was significantly associated with marital status, mode of delivery, lower BMI on postpartum day 2, and a positive change in the overhydration index (ΔOH). Women in this group exhibited significantly lower PLBI and sPLBI values, indicating more effective postpartum weight recovery and a greater return toward pre-pregnancy BMI. Hydration parameters derived from BIA differentiated between shorter and longer breastfeeding duration. Conclusions: Positive postpartum hydration balance (ΔOH ≥ 0) and efficient metabolic recovery, reflected by lower PLBI and sPLBI values, may support longer breastfeeding. BIA-based assessment of hydration and body composition could help identify women at higher risk of early breastfeeding cessation. Further longitudinal research is warranted to confirm the clinical utility of BIA in postpartum care and its potential role in early lactation support. Full article
(This article belongs to the Special Issue Obesity, Hormones, and Metabolic Complications in Pregnancy)
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22 pages, 1754 KB  
Article
Maternal Vitamin D Status, Oxidative Stress, and Implications for Neonatal Development: A Cross-Sectional Study
by Tania Flores-Bazán, Jacqueline Scarlett Barreto-González, José Pedraza-Chaverri, Omar Noel Medina-Campos, Araceli Castañeda-Ovando, Jeannett Alejandra Izquierdo-Vega, Diego Estrada-Luna, Martha Eunice Rodríguez-Arellano and Angélica Saraí Jiménez-Osorio
Metabolites 2026, 16(1), 19; https://doi.org/10.3390/metabo16010019 - 24 Dec 2025
Abstract
Background: Vitamin D (VD) plays a central role in calcium homeostasis during pregnancy and has been implicated in redox-related biological processes. While VD deficiency (VDD) has been consistently associated with adverse pregnancy outcomes, the relationships between VD insufficiency (VDI), maternal antioxidant-related biomarkers, [...] Read more.
Background: Vitamin D (VD) plays a central role in calcium homeostasis during pregnancy and has been implicated in redox-related biological processes. While VD deficiency (VDD) has been consistently associated with adverse pregnancy outcomes, the relationships between VD insufficiency (VDI), maternal antioxidant-related biomarkers, and neonatal outcomes remain incompletely characterized, particularly during the third trimester. Objective: To determines the prevalence of VDI in third-trimester pregnant women and to examine its associations with antioxidant-related markers and selected neonatal outcomes. Methods: A cross-sectional study was conducted among pregnant women in the third trimester attending a tertiary referral hospital in Mexico City. Maternal serum 25-hydroxyvitamin D (25-OHD) concentrations were measured, along with a panel of redox-related markers, including 2,2-diphenyl-2-2picrylhydrazyl (DPPH) radical scavenging activity, reduced glutathione (GSH), glutathione S-transferase (GST), glutathione peroxidase (GPx), and oxygen radical absorbance capacity (ORAC). Neonatal anthropometric parameters were recorded at birth. Associations between maternal VD status, redox-related markers, environmental factors, and neonatal outcomes were evaluated using appropriate statistical analyses. Results: A high prevalence of VDI was observed in the study population. Maternal VDI was associated with lower activities of GSH, GST, and GPx. Passive exposure to tobacco smoke and season of sampling were also associated with lower VD concentrations. Neonates born to women with VDI had higher birth weight compared with those born to women with sufficient VD concentrations. Maternal serum 25-OHD concentrations correlated positively with selected antioxidant enzyme activities. Conclusions: In this cohort of third-trimester pregnant women, VDI co-occurred with environmental factors, differences in maternal redox-related markers, and selected neonatal outcomes. These findings support an associative framework in which suboptimal VD status during the third trimester is accompanied by variations in redox-related markers. Longitudinal and mechanistic studies are needed to clarify the temporal sequence and biological relevance of these associations. Full article
(This article belongs to the Special Issue Obesity, Hormones, and Metabolic Complications in Pregnancy)
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