Valorization of Plant Extracts in the Pharmaceutical, Cosmetic and Pest Control Sectors: Trends and Advances

A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Plant Metabolism".

Deadline for manuscript submissions: closed (20 November 2023) | Viewed by 3200

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Department of Sustainable Agriculture, University of Patras, GR-30131 Agrinio, Greece
Interests: photocatalysis; visible-light photocatalysts; water treatment; hybrid systems; decontamination; detoxification; reactive species; transformation products
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Department of Pharmacy, University of Patras, 26504 Patras, Greece
Interests: pharmacognosy; natural products; phytochemicals; herbal extract quality control; antioxidant activity; neuroprotection
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Guest Editor
Department of Food Science & Technology, University of Patras, 30100 Agrinio, Greece
Interests: environmental pollution; pesticides science; biopesticides; soil contamination; water resources management; plant species diversity

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Guest Editor
Department of Environmental Engineering, University of Patras, 30100 Agrinio, Greece
Interests: microbial ecology; genomics; metagenomics; endosymbionts
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Special Issue Information

Dear Colleagues,

Plant extracts are important sources of various biologically active compounds such as phytosterols, amino acids, lipids, phenols, flavonoids, anthocyanins, alkaloids, and terpenoids, amongst others. These compounds exhibit diverse beneficial biological activities and are therefore used in a wide range of application fields. Bearing in mind they possess antioxidant, anti-inflammatory, antidiabetic, antibacterial, anti-fungal, anticonvulsant, and anticancer properties, there has been over the last few decades a tremendous increase in the use of plant extracts for therapeutic and prophylactic purposes or in cosmetic formulations. Furthermore, plant extracts, which are comprised of various bioactive compounds, are also recommended as natural biopesticides. This is because they can help control pests and weeds, ensuring food security, protection of the natural environment, and human health. In addition, the use of plant extracts as natural biopesticides can also help reduce the number of chemical pesticides used in agriculture, which is beneficial for the environment. As a result, plant extracts are becoming increasingly important in various fields, including medicine, agriculture, and environmental protection.

Based on the above, authors are invited to submit original articles and reviews on plant extracts and their application in extraction methods, chemical characterization of the extracts and identification of their bioactive molecules, evaluation of their bioactivities (e.g., antioxidative, anti-inflammatory, anti-infectious, anti-fungal activity, etc.), selectivity to non-target organisms, and molecular and physiological mechanisms of action, etc. Articles on alternative sources for potentially bioactive molecules such as microorganisms are also welcome.

Dr. Maria Antonopoulou
Prof. Fotini N. Lamari
Dr. Vassilios Triantafyllidis
Prof. Dr. George Tsiamis
Guest Editors

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Keywords

  • essential oils
  • bioactive compounds
  • metabolites
  • natural products
  • bioactivity
  • molecular mechanism of action
  • selectivity
  • integrated pest management
  • biopesticides

Published Papers (2 papers)

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Review

39 pages, 1578 KiB  
Review
Plant-Derived Senotherapeutics for the Prevention and Treatment of Intervertebral Disc Degeneration and Aging
by Eleni Mavrogonatou and Dimitris Kletsas
Metabolites 2024, 14(3), 146; https://doi.org/10.3390/metabo14030146 - 28 Feb 2024
Viewed by 1105
Abstract
Chronic low back pain, a major cause of disability with a great global socioeconomic impact, has been inextricably associated with intervertebral disc degeneration. On the other hand, an enhanced number of senescent cells has been identified in aged and degenerated intervertebral discs and [...] Read more.
Chronic low back pain, a major cause of disability with a great global socioeconomic impact, has been inextricably associated with intervertebral disc degeneration. On the other hand, an enhanced number of senescent cells has been identified in aged and degenerated intervertebral discs and their senescence-associated secretory phenotype (SASP) has been connected with qualitative/quantitative alterations in the extracellular matrix and ultimately with the disturbance of tissue homeostasis. Given that selective elimination of senescent cells (by the so-called senolytics) or amendment of their secretome towards a less catabolic/inflammatory phenotype (by molecules known as senomorphics) has been reported to alleviate symptoms of several age-associated diseases and to improve tissue quality during aging, here we will review the emerging role of senolytic and senomorphic agents derived from plants and natural products against intervertebral disc degeneration. The mode of action of these senotherapeutics, as well as the challenges in their practical application, will also be explicitly discussed in an attempt to direct their more targeted and effective use in exclusive or combinatorial therapeutic schemes for the prevention and/or treatment of disc degenerative disorders. Full article
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40 pages, 1185 KiB  
Review
Mediterranean Plants as Potential Source of Biopesticides: An Overview of Current Research and Future Trends
by Regina Fragkouli, Maria Antonopoulou, Elias Asimakis, Alexandra Spyrou, Chariklia Kosma, Anastasios Zotos, George Tsiamis, Angelos Patakas and Vassilios Triantafyllidis
Metabolites 2023, 13(9), 967; https://doi.org/10.3390/metabo13090967 - 22 Aug 2023
Cited by 4 | Viewed by 1545
Abstract
The development and implementation of safe natural alternatives to synthetic pesticides are urgent needs that will provide ecological solutions for the control of plant diseases, bacteria, viruses, nematodes, pests, and weeds to ensure the economic stability of farmers and food security, as well [...] Read more.
The development and implementation of safe natural alternatives to synthetic pesticides are urgent needs that will provide ecological solutions for the control of plant diseases, bacteria, viruses, nematodes, pests, and weeds to ensure the economic stability of farmers and food security, as well as protection of the environment and human health. Unambiguously, production of botanical pesticides will allow for the sustainable and efficient use of natural resources and finally decrease the use of chemical inputs and burden. This is further underlined by the strict regulations on pesticide residues in agricultural products and is in harmony with the Farm to Fork strategy, which aims to reduce pesticide use by 50% by 2030. Thus, the present work aims to compile the scientific knowledge of the last 5 years (2017–February 2023) regarding the Mediterranean plants that present biopesticidal effects. The literature review revealed 40 families of Mediterranean plants with at least one species that have been investigated as potential biopesticides. However, only six families had the highest number of species, and they were reviewed comprehensively in this study. Following a systematic approach, the extraction methods, chemical composition, biopesticidal activity, and commonly used assays for evaluating the antimicrobial, pesticidal, repellant, and herbicidal activity of plant extracts, as well as the toxicological and safety aspects of biopesticide formulation, are discussed in detail. Finally, the aspects that have not yet been investigated or are under-investigated and future perspectives are highlighted. Full article
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