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Hormones and Metabolic Syndrome: Importance of Hormones in the Epidemiology,...
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Hormones and Metabolic Syndrome: Importance of Hormones in the Epidemiology, Physiopathology and Treatment of Metabolic Disorders

A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Endocrinology and Clinical Metabolic Research".

Deadline for manuscript submissions: closed (31 October 2023) | Viewed by 5096

Special Issue Editors

Prof. Dr. Rodolfo Pinto-Almazán

E-Mail Website
Guest Editor
Escuela Superior de Medicina, Instituto Politécnico Nacional, Mexico City, Mexico
Interests: metabolic syndrome; sex differences; hormones; oxidative stress; neurodegeneration
Dr. Carlos Alfonso Larqué Velázquez

E-Mail Website
Guest Editor
Departamento de Embriología y Genética, Facultad de Medicina, Universidad Nacional Autónoma de México, Ciudad de México 04510, Mexico
Interests: pancreatic beta cells; insulin secretion; intergenerational obesity; metabolic syndrome; diabetes mellitus type 2
Dr. Marco Antonio Loza-Mejía

E-Mail Website
Guest Editor
Design, Isolation and Synthesis of Bioactive Molecules Research Group, Chemical Sciences Department, Universidad La Salle-México, Mexico City 06140, Mexico
Interests: computer-aided drug design; multitarget drugs; metabolic syndrome; heterocyclic chemistry
Dr. Myrian Velasco

E-Mail Website
Guest Editor
Departamento de Neurociencia Cognitiva, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Ciudad Universitaria, Coyoacán, Ciudad de Mexico 04510, Mexico
Interests: metabolic syndrome; pancreatic beta cells; KATP and Kv2 potassium channels; sexual dimorphism; obesity and type 2 diabetes mellitus
Dr. Marcia Hiriart

E-Mail Website
Guest Editor
Cognitive Neuroscience Department, Neuroscience Division, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México UNAM, Mexico City 04510, Mexico
Interests: insulin; pancreatic beta cells; metabolic syndrome; sexual dimorphism
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Metabolic disorders (MetDis) are a group of pathologies (central obesity, insulin resistance, dyslipidemia, hypertension, etc.) that cause alterations in normal metabolic processes. They are currently highly prevalent in the world. Scientific evidence has demonstrated sexual differences in the epidemiology, pathophysiology and clinical expression of metabolic syndrome and therefore in the treatment of MetDis. In addition, size and physiology of adipocytes, distribution of body fat, hormonal regulation of body weight and adiposity, regulation of blood pressure, glucose and lipid homeostasis and insulin sensitivity have been associated with sex differences.

The multifactorial origin and chronic duration of MetDis contribute to the complexity of their pharmacological interventions/treatment. Several reports have attempted to elucidate predisposing genetic and environmental (lifestyle and nutrition) factors and their underlying pathophysiological molecular mechanisms/cellular pathways (oxidative stress and inflammation) to develop an improved understanding of these conditions and offer the best therapeutic options to treat them.

This Special Issue will focus on original and review articles describing sex differences in MetDis, including the epidemiological and clinical data of MetDis, in silico studies for molecular targets involved in MetDis therapeutics, in vitro and in vivo studies focused on molecular/cellular mechanisms associated with MetDis, studies of natural products, synthetic compounds and repositioning of drugs for MetDis based on the multitarget strategy for treating MetDis.

Prof. Dr. Rodolfo Pinto-Almazán
Dr. Carlos Alfonso Larqué Velázquez
Dr. Marco Antonio Loza-Mejía
Dr. Myrian Velasco
Dr. Marcia Hiriart
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • metabolic disorders
  • sex differences
  • hormones
  • physiopathology
  • epidemiology
  • basic and clinical studies

Published Papers (3 papers)

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Research

16 pages, 1524 KiB  
Article
In Silico and In Vivo Evaluation of the Maqui Berry (Aristotelia chilensis (Mol.) Stuntz) on Biochemical Parameters and Oxidative Stress Markers in a Metabolic Syndrome Model
by Emily Leonela Castillo-García, Ana Lizzet Cossio-Ramírez, Óscar Arturo Córdoba-Méndez, Marco A. Loza-Mejía, Juan Rodrigo Salazar, Edwin Chávez-Gutiérrez, Guadalupe Bautista-Poblet, Nadia Tzayaka Castillo-Mendieta, Diego A. Moreno, Cristina García-Viguera, Rodolfo Pinto-Almazán, Julio César Almanza-Pérez, Juan Manuel Gallardo and Christian Guerra-Araiza
Metabolites 2023, 13(12), 1189; https://doi.org/10.3390/metabo13121189 - 7 Dec 2023
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Abstract
Metabolic syndrome (MetS) is a complex disease that includes metabolic and physiological alterations in various organs such as the heart, pancreas, liver, and brain. Reports indicate that blackberry consumption, such as maqui berry, has a beneficial effect on chronic diseases such as cardiovascular [...] Read more.
Metabolic syndrome (MetS) is a complex disease that includes metabolic and physiological alterations in various organs such as the heart, pancreas, liver, and brain. Reports indicate that blackberry consumption, such as maqui berry, has a beneficial effect on chronic diseases such as cardiovascular disease, obesity, and diabetes. In the present study, in vivo and in silico studies have been performed to evaluate the molecular mechanisms implied to improve the metabolic parameters of MetS. Fourteen-day administration of maqui berry reduces weight gain, blood fasting glucose, total blood cholesterol, triacylglycerides, insulin resistance, and blood pressure impairment in the diet-induced MetS model in male and female rats. In addition, in the serum of male and female rats, the administration of maqui berry (MB) improved the concentration of MDA, the activity of SOD, and the formation of carbonyls in the group subjected to the diet-induced MetS model. In silico studies revealed that delphinidin and its glycosylated derivatives could be ligands of some metabolic targets such as α-glucosidase, PPAR-α, and PPAR-γ, which are related to MetS parameters. The experimental results obtained in the study suggest that even at low systemic concentrations, anthocyanin glycosides and aglycones could simultaneously act on different targets related to MetS. Therefore, these molecules could be used as coadjuvants in pharmacological interventions or as templates for designing new multitarget molecules to manage patients with MetS. Full article
(This article belongs to the Special Issue Hormones and Metabolic Syndrome: Importance of Hormones in the Epidemiology, Physiopathology and Treatment of Metabolic Disorders)
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14 pages, 2321 KiB  
Article
Lifestyle and Quality of Life of Women Diagnosed with Hypothyroidism in the Context of Non-Alcoholic Fatty Liver
by Barbara Janota, Brygida Adamek, Elżbieta Szczepańska, Krzysztof Biernacki and Ewa Janczewska
Metabolites 2023, 13(12), 1174; https://doi.org/10.3390/metabo13121174 - 26 Nov 2023
Cited by 1 | Viewed by 1014
Abstract
Interconnections between hypothyroidism and metabolic disturbances manifesting in the liver and body composition have not yet been comprehensively analyzed in the context of lifestyle. This study aimed to assess the selected lifestyle factors and quality of life in the context of the development [...] Read more.
Interconnections between hypothyroidism and metabolic disturbances manifesting in the liver and body composition have not yet been comprehensively analyzed in the context of lifestyle. This study aimed to assess the selected lifestyle factors and quality of life in the context of the development of NAFL (non-alcoholic fatty liver) in women diagnosed with hypothyroidism. This study included 134 women categorized into three groups: with hypothyroidism and NAFL, with only hypothyroidism, and with only NAFL. We compared the groups concerning the KomPAN and WHOQOL-BREF questionnaires, anthropometric measurements, body composition parameters, and the stage of liver steatosis. The individuals with NAFL most frequently consumed lard, fried dishes, processed meats, red meat, sweets, and sweetened beverages. The individuals with hypothyroidism without coexisting NAFL exhibited the highest satisfaction with health. The NAFL group had the highest average body fat percentage. Selected lifestyle aspects influenced the development of NAFL in women diagnosed with hypothyroidism. Women’s overall quality of life did not vary depending on the coexisting medical conditions. Preventive programs should promote the following: the regular consumption of meals, the appropriate energy supply, physical activity, mental health support, and striving for proper body composition parameters. Full article
(This article belongs to the Special Issue Hormones and Metabolic Syndrome: Importance of Hormones in the Epidemiology, Physiopathology and Treatment of Metabolic Disorders)
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14 pages, 4056 KiB  
Article
Paternal Obesity Induced by High-Fat Diet Impairs the Metabolic and Reproductive Health of Progeny in Rats
by Carlos Larqué, Haydée Lugo-Martínez, Xiadany Mendoza, Monserrat Nochebuena, Luis Novo, Ricardo Vilchis, Guadalupe Sánchez-Bringas, Laura Ubaldo, Myrian Velasco and Rene Escalona
Metabolites 2023, 13(10), 1098; https://doi.org/10.3390/metabo13101098 - 20 Oct 2023
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Abstract
Due to the increased incidence of obesity, it is of great importance to identify all the possible consequences in those who suffer from it and their descendants. This study aimed to investigate how paternal obesity, resulting from an 18-week high-fat diet (HFD), affects [...] Read more.
Due to the increased incidence of obesity, it is of great importance to identify all the possible consequences in those who suffer from it and their descendants. This study aimed to investigate how paternal obesity, resulting from an 18-week high-fat diet (HFD), affects the metabolic and reproductive health of offspring. In the fathers (F0 generation), the HFD led to significant weight gain, primarily due to increased visceral fat. It also resulted in impaired glucose control and reduced insulin sensitivity. Furthermore, F0 males from the HFD group had reduced sperm concentration and lower sperm viability but were still able to sire litters. F1 offspring were monitored during 18 weeks; F1 offspring from obese fathers displayed increased body weight during the experimental window, especially in males, without significant metabolic disturbances. Additionally, F1 males showed reduced sperm viability, indicating potential reproductive implications. On the other hand, F1 females showed normal estrous cycle patterns but had a reduced number of primordial follicles, suggesting a decrease in their follicular reserve and reproductive potential. This study highlights that metabolic and reproductive issues may be passed down to future generations through the paternal line. Full article
(This article belongs to the Special Issue Hormones and Metabolic Syndrome: Importance of Hormones in the Epidemiology, Physiopathology and Treatment of Metabolic Disorders)
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