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Metabolites
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Molecular Mechanisms in Cancer, Cardiovascular and Metabolic Diseases: Potential Therapies...
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Molecular Mechanisms in Cancer, Cardiovascular and Metabolic Diseases: Potential Therapies and Treatments

A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Endocrinology and Clinical Metabolic Research".

Deadline for manuscript submissions: closed (18 December 2024) | Viewed by 5471

Special Issue Editor

Dr. Alex Cleber Improta-Caria

E-Mail Website
Guest Editor
Laboratory of Biochemistry and Molecular Biology of the Exercise, Physical Education and Sport School, University of São Paulo, São Paulo 05508-030, Brazil
Interests: molecular mechanisms; cancer; cardiovascular diseases; metabolic diseases; treatments

Special Issue Information

Dear Colleagues,

Cardiovascular diseases and cancers are the main causes of death worldwide, and recently it has been reported that cardiovascular and metabolic diseases favor the development of cancers. In recent years, several studies have shown various deregulated cellular and molecular mechanisms favoring pathophysiological processes such as inflammation, increase in reactive oxygen species, apoptosis and fibrosis inducing the development and progression of these diseases, including many of these molecular mechanisms are regulated by non-coding RNAs such as microRNAs, circRNAs and long-non-coding RNAs. Understanding these mechanisms will enable the creation of new treatments, and these molecules can serve as new biomarkers for diagnosis and targeted gene therapy. Therefore, this Special Edition is focused on articles that can elucidate new signaling pathways deregulated in cancer, cardiovascular and metabolic diseases, as well as articles that evaluate the response to treatments for these diseases. We welcome submissions of original pre-clinical and clinical articles, reviews, mini-reviews and letters.

Dr. Alex Cleber Improta-Caria
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • molecular mechanisms
  • cancer
  • cardiovascular diseases
  • metabolic diseases
  • treatments

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Published Papers (2 papers)

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Research

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17 pages, 2813 KiB  
Article
Cardiometabolic and Cellular Adaptations to Multiple vs. Single Daily HIIT Sessions in Wistar Rats: Impact of Short-Term Detraining
by Liliane Vanessa Costa-Pereira, Bruno Ferreira Mendes, Caíque Olegário Diniz Magalhães, Cíntia Maria Rodrigues, Júllia Alves de Andrade, Ramona Ramalho Souza de Pereira, Elizabethe Adriana Esteves, Ricardo Cardoso Cassilhas, Eric Francelino Andrade, Fernando Gripp, Flávio Castro de Magalhães, Kinulpe Honorato Sampaio, Alex Cleber Improta-Caria, Fabiano Trigueiro Amorim and Marco Fabrício Dias-Peixoto
Metabolites 2024, 14(8), 447; https://doi.org/10.3390/metabo14080447 - 14 Aug 2024
Viewed by 1502
Abstract
Multiple short daily bouts of HIIT are more effective than single daily sessions in improving cardiometabolic and cellular adaptations in rats. We hypothesize that a short period of detraining is sufficient to abolish the superior adaptive responses to multiple versus single daily sessions [...] Read more.
Multiple short daily bouts of HIIT are more effective than single daily sessions in improving cardiometabolic and cellular adaptations in rats. We hypothesize that a short period of detraining is sufficient to abolish the superior adaptive responses to multiple versus single daily sessions of HIIT in rats. Male rats were divided into untrained, 1xHIIT, and 3xHIIT groups. Over eight weeks, the 1xHIIT group performed 115 min single daily sessions of HIIT, while the 3xHIIT group performed three 5 min sessions with 4 h intervals. After training, both groups remained sedentary for four weeks (detraining). Resting oxygen consumption (VO2), body composition, glucose/insulin tolerance, and blood pressure were recorded. After euthanasia, cardiac function/histology and gastrocnemius mitochondrial density were analyzed. After training, both 1xHIIT and 3xHIIT protocols induced similar improvements in VO2, maximal oxygen uptake (VO2max), cardiac function/hypertrophy, and gastrocnemius mitochondrial density. These effects were maintained even after detraining. Only the 3xHIIT protocol improved insulin sensitivity. After detraining, this effect was abolished. After training, both 1xHIIT and 3xHIIT protocols reduced adiposity. After detraining, the adiposity increased in both groups, with a more pronounced increase in the 3xHIIT rats. A four-week detraining period abolishes the superior adaptive responses to multiple versus single daily HIIT sessions in rats. Full article
(This article belongs to the Special Issue Molecular Mechanisms in Cancer, Cardiovascular and Metabolic Diseases: Potential Therapies and Treatments)
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Review

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27 pages, 688 KiB  
Review
Nicotinamide N-Methyltransferase (NNMT): A New Hope for Treating Aging and Age-Related Conditions
by Jing-Jing Li, Wei-Dong Sun, Xiao-Juan Zhu, Ya-Zhong Mei, Wen-Song Li and Jiang-Hua Li
Metabolites 2024, 14(6), 343; https://doi.org/10.3390/metabo14060343 - 19 Jun 2024
Cited by 5 | Viewed by 3467
Abstract
The complex process of aging leads to a gradual deterioration in the function of cells, tissues, and the entire organism, thereby increasing the risk of disease and death. Nicotinamide N-methyltransferase (NNMT) has attracted attention as a potential target for combating aging and its [...] Read more.
The complex process of aging leads to a gradual deterioration in the function of cells, tissues, and the entire organism, thereby increasing the risk of disease and death. Nicotinamide N-methyltransferase (NNMT) has attracted attention as a potential target for combating aging and its related pathologies. Studies have shown that NNMT activity increases over time, which is closely associated with the onset and progression of age-related diseases. NNMT uses S-adenosylmethionine (SAM) as a methyl donor to facilitate the methylation of nicotinamide (NAM), converting NAM into S-adenosyl-L-homocysteine (SAH) and methylnicotinamide (MNA). This enzymatic action depletes NAM, a precursor of nicotinamide adenine dinucleotide (NAD+), and generates SAH, a precursor of homocysteine (Hcy). The reduction in the NAD+ levels and the increase in the Hcy levels are considered important factors in the aging process and age-related diseases. The efficacy of RNA interference (RNAi) therapies and small-molecule inhibitors targeting NNMT demonstrates the potential of NNMT as a therapeutic target. Despite these advances, the exact mechanisms by which NNMT influences aging and age-related diseases remain unclear, and there is a lack of clinical trials involving NNMT inhibitors and RNAi drugs. Therefore, more in-depth research is needed to elucidate the precise functions of NNMT in aging and promote the development of targeted pharmaceutical interventions. This paper aims to explore the specific role of NNMT in aging, and to evaluate its potential as a therapeutic target. Full article
(This article belongs to the Special Issue Molecular Mechanisms in Cancer, Cardiovascular and Metabolic Diseases: Potential Therapies and Treatments)
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