Metabolic Changes in Diet-Mediated Inflammatory Diseases

A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Nutrition and Metabolism".

Deadline for manuscript submissions: 30 September 2025 | Viewed by 301

Special Issue Editor


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Guest Editor
1.Department of Bioscience and Technology for Food, Agriculture and Environment, University of Teramo, 64100 Teramo, Italy
2.Center for Advanced Studies and Technology (CAST), ‘G. d’Annunzio’ University of Chieti-Pescara, 66100 Chieti, Italy
Interests: inflammation; cancer; immune system; tumoral microenvironment; metabolic reprogramming; autoimmune disease

Special Issue Information

Dear Colleagues,

The incidence of several inflammatory disorders and autoinflammatory diseases has increased dramatically in Western countries over the past few decades. The inflammatory process negatively affects all physiological functions, causing several pathological conditions such as cancer, neurodegeneration, immune disorders, and metabolic syndromes. The strong inflammatory component present in this array of degenerative conditions is affected by lifestyles and diets. The nutritional changes that occurred in Western countries determined an increase in the consumption of energy-dense, nutrient-poor, and ultra-processed foods. Epidemiological studies correlate this “Westernized diet” to characteristic metabolic changes in inflammatory tissues with nutrient depletion, increased oxygen consumption, and oxidative stress, responsible for the activation of the immune response. Interestingly, diet metabolites can reduce or delay the onset of immune-mediated diseases, making nutritional intervention a possible strategy in immunotherapy. The purpose of this Special Issue is to take stock of the complex networks between diet, metabolic reprogramming, and immune response. It will consider original research, short communications, and reviews based on, but not limited to, understanding the intricate interplay between diet-related metabolic changes and immune response activation.

Dr. Beatrice Dufrusine
Guest Editor

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Keywords

  • nutrition
  • Westernized diet
  • inflammation
  • immune system
  • cancer
  • metabolic reprogramming
  • au-toimmune disease
  • obesity
  • allergies
  • inflammatory bowel diseases
  • celiac disease

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Published Papers (1 paper)

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Research

25 pages, 2807 KB  
Article
A Holistic Approach to Metabolic Health Assessment—Analysis of Bioimpedance, Blood, and Saliva Biochemistry in Population Studies—A Pilot Study
by Aleksandra Stawiarska, Renata Francik, Anna Mikulec, Marek Zborowski, Urszula Cisoń-Apanasewicz, Ryszard Gajdosz, Iwona Zaczyk, Halina Potok, Agnieszka Radom, Dorota Ogonowska and Elżbieta Rafa
Metabolites 2025, 15(9), 591; https://doi.org/10.3390/metabo15090591 (registering DOI) - 7 Sep 2025
Abstract
Background: Metabolic syndrome is a multifaceted condition involving lipid and carbohydrate metabolism disorders and hypertension, increasing the risk of cardiovascular disease and type 2 diabetes. Accurate diagnosis and prevention require an interdisciplinary approach that includes both traditional lab tests and modern, non-invasive health [...] Read more.
Background: Metabolic syndrome is a multifaceted condition involving lipid and carbohydrate metabolism disorders and hypertension, increasing the risk of cardiovascular disease and type 2 diabetes. Accurate diagnosis and prevention require an interdisciplinary approach that includes both traditional lab tests and modern, non-invasive health assessments. Methods: This study aimed to evaluate metabolic health in adults from the Małopolska Voivodeship by analyzing the relationships between obesity indicators (BMI, waist circumference) and anthropometric, blood, and salivary biomarkers. Sixty-three participants (36 women, 27 men) aged 40–71 underwent body composition analysis (InBody 770), anthropometric measurements, and biochemical tests of blood and saliva. Assessed parameters included body composition (BMI, BFM, FFM, SMM, PBF, VFA, PA), blood pressure, blood biomarkers (glucose, TG, LDL, HDL, HbA1c, insulin, cortisol), and salivary markers (FRAP, DPPH, urea, amylase activity, protein content, pH, buffering capacity). Results: The results showed a strong correlation between body composition and biochemical markers, but the results of the analyzed salivary biomarkers were inconclusive and, in some cases, contradictory to the findings of other authors. Conclusions: Fat mass, cell integrity, and diastolic pressure were key determinants of waist circumference. Our research confirms the validity of using combined diagnostics, bioimpedance, and blood analysis for a comprehensive assessment of metabolic health and indicates the direction for further research using salivary biomarkers. A holistic approach improves risk assessment and strengthens preventive and therapeutic strategies. However, our pilot study showed that the research requires a larger sample size, especially in order to draw representative conclusions regarding salivary biomarkers and their relationship to metabolic health. Full article
(This article belongs to the Special Issue Metabolic Changes in Diet-Mediated Inflammatory Diseases)
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