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Metabolites
Special Issues
Physiological Activity and Metabolic Mechanism of Dietary Functional Factors
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Physiological Activity and Metabolic Mechanism of Dietary Functional Factors

A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Food Metabolomics".

Deadline for manuscript submissions: closed (31 October 2023) | Viewed by 5286

Special Issue Editors

Dr. Yansheng Zhao

E-Mail Website
Guest Editor
School of Food and Biological Engineering, Jiangsu University, Zhenjiang, China
Interests: functional food; physiological activity; metabolic syndrome
Dr. Juan Bai

E-Mail Website
Guest Editor
School of Food and Biological Engineering, Jiangsu University, Zhenjiang, China
Interests: functional food; metabolic mechanism; metabolic syndrome
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Numerous epidemiological, clinical, and experimental studies have reported that the physiological activities of dietary functional factors are closely related to the prevention of chronic non-communicable diseases (NCDs) and the promotion of human health. Therefore, it is beneficial to the development of precise nutrition and personalized functional foods by revealing the metabolic mechanism of functional factors during dietary intervention, which has been regarded as a key point in the field of food nutrition and health.

Non-targeted analysis based on modern omics technology, such as proteomics and metabolomics, helps to establish the correlation between the health benefits of functional food and the physiological activities of its bioactive components, and further explore biomarkers after dietary intake. Meanwhile, based on the analysis of the metabolic mechanism of dietary functional factors, the information of endogenous metabolites, metabolic pathways and metabolic networks, etc., will be conductive to elucidate the association between dietary nutrition and health, and deepen our understanding of the efficacy of dietary interventions in disease prevention and human health promotion.

This Special Issue of Metabolites, “Physiological Activity and Metabolic Mechanism of Dietary Functional Factors”, will publish reviews and original articles covering the latest developments of the physiological activities, metabolic process, typical metabolites and metabolic mechanism of dietary functional factors, and the connections between functional factors, including their metabolites and human health. Furthermore, innovative methods and techniques used to analyze, identify, and reveal the metabolic mechanism of dietary functional factors will be welcome.

Dr. Yansheng Zhao
Dr. Juan Bai
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

 

Keywords

  • dietary functional factor
  • physiological activity
  • metabolic mechanism
  • metabolites
  • metabolomics

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Published Papers (2 papers)

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Research

14 pages, 1942 KiB  
Article
Chlorogenic Acid of Cirsium japonicum Resists Oxidative Stress Caused by Aging and Prolongs Healthspan via SKN-1/Nrf2 and DAF-16/FOXO in Caenorhabditis elegans
by Myogyeong Cho, Yebin Kim, Sohyeon You, Dae Youn Hwang and Miran Jang
Metabolites 2023, 13(2), 224; https://doi.org/10.3390/metabo13020224 - 3 Feb 2023
Cited by 10 | Viewed by 2241
Abstract
To evaluate the value of Cirsium japonicum (CJ; thistle) as a material for functional foods, we studied the functional composition of cultivated CJ and the in vitro and in vivo antioxidant activity of the functional substance. The detected phenolics in farmed CJ were [...] Read more.
To evaluate the value of Cirsium japonicum (CJ; thistle) as a material for functional foods, we studied the functional composition of cultivated CJ and the in vitro and in vivo antioxidant activity of the functional substance. The detected phenolics in farmed CJ were chlorogenic acid (CA), linarin (LIN), and pectolinarin (PLIN) by HPLC analysis. As a result of the antioxidant activity of CJ and its phenolics by DPPH and ABTS method, CA had shown the greatest antioxidant activity. We employed Caenorhabditis elegans to validate that in vitro effects of CA are shown in vivo. CA delayed reduction in pumping rate and progeny production during aging of C. elegans. Under both normal and oxidative stress conditions, CA reduced the production of reactive oxygen species (ROS) in worms and increased their lifespan. In particular, CA showed the reducing effect of ROS accumulation due to aging in aged worms (8 days old). To gain insight into the mechanism, we used skn-1/Nrf2 and daf-16/FOXO transformed worms. The CA effects (on catalase activity and lifespan extension) in the wild-type (WT) decreased in skn-1 and daf-16 mutants. In particular, CA strongly relied on daf-16 under mild oxidative condition and skn-1 under overall (from mild to strong) oxidative stress to reduce ROS and extend healthspan. Thus, we conclude that CA, a key bioactive phenolic of CJ, reduces ROS production and ultimately extends healthspan, and this effect is the result of actions of daf-16 or skn-1 at different stages depending on the degree of oxidation or aging. Our results suggest that CJ containing CA can be used as an antiaging material due to its antioxidant properties. Full article
(This article belongs to the Special Issue Physiological Activity and Metabolic Mechanism of Dietary Functional Factors)
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15 pages, 3512 KiB  
Article
Metabolomics Reveal the Regulatory Effect of Polysaccharides from Fermented Barley Bran Extract on Lipid Accumulation in HepG2 Cells
by Yan-Sheng Zhao, Xin-Meng Tong, Xue-Mei Wu, Juan Bai, Song-Tao Fan, Ying Zhu, Jia-Yan Zhang and Xiang Xiao
Metabolites 2023, 13(2), 223; https://doi.org/10.3390/metabo13020223 - 3 Feb 2023
Cited by 9 | Viewed by 2379
Abstract
Barley bran has potential bioactivities due to its high content of polyphenols and dietary fiber, etc. Fermentation has been considered as an effective way to promote the functional activity of food raw materials. In this study, polysaccharides from barley bran extract fermented by [...] Read more.
Barley bran has potential bioactivities due to its high content of polyphenols and dietary fiber, etc. Fermentation has been considered as an effective way to promote the functional activity of food raw materials. In this study, polysaccharides from barley bran extract fermented by Lactiplantibacillus plantarum dy-1 (FBBE-PS) were analyzed, and its effects on lipid accumulation and oxidative stress in high-fat HepG2 cells induced by sodium oleate were evaluated. The results showed that the molecular weight decreased and monosaccharide composition of polysaccharides changed significantly after fermentation. In addition, 50 μg/mL FBBE-PS could reduce the triglyceride (TG) content and reaction oxygen species (ROS) level in high-fat HepG2 cells by 21.62% and 30.01%, respectively, while increasing the activities of superoxide dismutase (SOD) and catalase (CAT) represented by 64.87% and 22.93%, respectively. RT-qPCR analysis revealed that FBBE-PS could up-regulate the lipid metabolism-related genes such as ppar-α, acox-1 and cpt-1α, and oxidation-related genes such as nrf2, ho-1, nqo-1, sod1, cat, etc. The metabolomics analysis indicated that FBBE-PS could alleviate lipid deposition by inhibiting the biosynthesis of unsaturated fatty acids, which is consistent with the downregulation of scd-1 expression. It is demonstrated that fermentation can alter the properties and physiological activities of polysaccharides in barley bran, and FBBE-PS exhibited an alleviating effect on lipid deposition and oxidative stress in high-fat cells. Full article
(This article belongs to the Special Issue Physiological Activity and Metabolic Mechanism of Dietary Functional Factors)
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