Mitochondrial Metabolism, Redox State and Immunology in Cancer
A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Endocrinology and Clinical Metabolic Research".
Deadline for manuscript submissions: 31 December 2025 | Viewed by 203
Special Issue Editors
Interests: cancer; mitochondria metabolism; redox state
Special Issue Information
Dear Colleagues,
Several antitumor therapies exert their function through immunity and/or redox status management. Both of these therapeutic targets are closely related to mitochondrial metabolism in the tumoral microenvironment, and involve immune cells, stromal cells, blood vessels, and the extracellular matrix. For example, some types of cancer have been found to require certain levels of reactive oxygen species (ROS) for their maintenance and growth, while other types of cancer, instead, need reduced levels of ROS, with mitochondria being the main organelles in the regulation of ROS. In addition, immune cells also depend on mitochondrial ROS and their metabolism to be activated or inhibited during cancer elimination. In support of this, it has been observed that cytotoxic T cells need mitochondrial ROS to activate and induce their cytotoxic activity against tumors, but on the other hand, elevated levels of ROS can activate regulatory T cells which suppress the antitumoral effects of cytotoxic T cells, promoting tumor growth. On the other hand, it should be noted that elevated levels of ROS also induce tumor death, as ROS can overcome the threshold of resistance to oxidative stress (OS), inducing mitochondrial damage and dysfunction and, consequently, the cell death of tumor cells. Finding these windows of opportunity in cancer elimination is a challenge. Therefore, the redox state and mitochondrial metabolism in both cancer cells and the immune system associated with tumor cell eradication are key events for cancer elimination. This Special Issue welcomes reviews and original research manuscripts exploring the effects of ROS and mitochondrial metabolism on both tumor cells and immune cells associated with their elimination, including treatments targeting these two fundamental aspects of cancer progression.
Dr. Alfredo Cruz-Gregorio
Prof. Dr. Gladis Fragoso
Guest Editors
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Keywords
- immune system
- mitochondria
- redox state
- cancer
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