Food Additives in Gut Microbiota and Metabolic Health

A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Nutrition and Metabolism".

Deadline for manuscript submissions: closed (15 April 2025) | Viewed by 1921

Special Issue Editors


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Guest Editor
Department of Food Science and Technology, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai 200240, China
Interests: Food components and intestinal microbiome

E-Mail Website
Guest Editor
School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai 200240, China
Interests: gut microbiota; intestinal health; antioxidant; nutrition

E-Mail Website
Guest Editor
Department of Food Science & Technology, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai 200240, China
Interests: synthetic biology; bioinformatics; skin microecology

Special Issue Information

Dear Colleagues,

As an important component of modern food, food additives are widely used to ensure food safety, enhance flavor and stability, improve food appearance, etc. Consumption of some food additives, for instance, emulsifiers, has recently been noted to greatly impact intestinal microbiota and human metabolic health. Studies and/or reviews investigating the impact of food additives on the intestinal microbiota and metabolic health could shed light on the field and support food additive use guidelines.

This Special Issue is devoted to the Nutrition and Metabolism section. We encourage studies from basic science to clinical trials, which investigate the impact of food additives on intestinal microbiota and/or metabolites.

Dr. Ran An
Dr. Jing Zhang
Dr. Heng Wang
Guest Editors

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Keywords

  • food additives
  • emulsifier
  • carbohydrates
  • intestine
  • microbiota

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Published Papers (1 paper)

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Research

14 pages, 1483 KiB  
Article
Exploring the Pharmacokinetics and Gut Microbiota Modulation of Hesperidin and Nobiletin from Mandarin Orange Peel in Experimental Dogs: A Pilot Study
by Jun Nakahigashi, Makoto Kurikami, Satomi Iwai, Sadahiko Iwamoto, Shou Kobayashi and Eiji Kobayashi
Metabolites 2025, 15(1), 3; https://doi.org/10.3390/metabo15010003 - 25 Dec 2024
Viewed by 1634
Abstract
Background/Objectives: Mandarin orange peel (MOP) is recognized for its traditional medicinal properties due to its high flavonoid content. This study aimed to analyze MOP harvested in Japan for specific bioactive compounds and to explore its health applications in dogs, including effects on gut [...] Read more.
Background/Objectives: Mandarin orange peel (MOP) is recognized for its traditional medicinal properties due to its high flavonoid content. This study aimed to analyze MOP harvested in Japan for specific bioactive compounds and to explore its health applications in dogs, including effects on gut microbiota and cognitive symptoms. Methods: Flavonoid content (particularly hesperidin and nobiletin) of MOP was measured. High-flavonoid MOP was then incorporated into gelatin cubes. In the time–course blood concentration study, experimental beagle dogs received a single oral dose (4 g). For intestinal microbiota analysis and blood biochemical tests, beagle dogs were administered 1 g twice daily. For the Demonstration Test, older dogs (a 14-year-old female Shiba Inu, a 14-year-old female Miniature Dachshund, and a 19-year-old male Miniature Dachshund) were administered 1 g twice daily. Analysis included microbiota profiling via 16S rDNA sequencing and observational assessment of cognitive indicators in a pilot study involving senior dogs with Alzheimer’s disease. Results: The MOP powder contained 9.3% hesperidin in early-ripening varieties (October harvest) and 6.9% in ripe varieties (December harvest). Nobiletin content was 41 mg/100 g (0.041%) and 35 mg/100 g (0.035%) for the early and late harvests, respectively. Administration of MOP-enriched gelatin cubes reduced Fusobacteriaceae and increased Eggerthellaceae. Cognitive symptoms like howling and counterclockwise turning showed improvement in senior dogs (n = 3). Conclusions: This study provides preliminary support for the potential health benefits of MOP in canine dietary applications, particularly for gut health and cognitive function. Improvement in cognitive symptoms may be due to the anxiolytic effects of mandarin peel. Full article
(This article belongs to the Special Issue Food Additives in Gut Microbiota and Metabolic Health)
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