Lipidomics as a Diagnostic Tool: Lipid Metabolism and Its Related Human Diseases

A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Lipid Metabolism".

Deadline for manuscript submissions: 29 November 2024 | Viewed by 2607

Special Issue Editors


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Guest Editor
Emory School of Medicine, Emory University, Atlanta, GA, USA
Interests: lipidomics; metabolomics; PUFA; oxylipins; endocannabinoids; nutrition; metabolic disease

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Guest Editor
Department of Molecular and Structural Biochemistry, North Carolina State University, Raleigh, NC 27695, USA
Interests: metabolic diseases; type 2 diabetes; fatty liver disease; cardiovascular disease; lipid

Special Issue Information

Dear Colleagues,

Lipid metabolism is involved in every facet of human physiology and the dysregulation of these processes is implicated in the onset and/or progression of various diseases. In recent years, we have seen lipidomics used as a powerful tool to identify potential lipid biomarkers. However, we are only at the tip of the proverbial iceberg. There are an estimated 60,000 lipid species, though only several thousand of these have been identified with high confidence. Despite this gap, those identified lipid species are shown to be integral to human physiology and pathology, leaving a breadth of information yet to be discovered. With advances in instrumentation and computational methods, we are learning more about the function of distinct lipids in the human lipidome as well as the delicate cross-talk between lipids and protein cofactors.

In this Special Issue, we seek to explore the use of lipidomics to better understand lipid metabolism. We aim to provide a more in-depth look into the human lipidome to potentially discover novel lipids, lipid mediators, or co-factors that are linked to human disease.

Dr. Kristal M. Maner-Smith
Dr. Arion J. Kennedy
Guest Editors

Manuscript Submission Information

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • lipidomics
  • metabolomics
  • nutrition
  • bioactive lipids
  • signaling lipids
  • polyunsaturated fatty acids
  • oxylipins
  • endocannabinoids
  • sphingolipids
  • ceramides

Published Papers (1 paper)

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Review

24 pages, 1421 KiB  
Review
Lipids in Psychiatric Disorders: Functional and Potential Diagnostic Role as Blood Biomarkers
by Yana Zorkina, Valeria Ushakova, Aleksandra Ochneva, Anna Tsurina, Olga Abramova, Valeria Savenkova, Anna Goncharova, Irina Alekseenko, Irina Morozova, Daria Riabinina, Georgy Kostyuk and Anna Morozova
Metabolites 2024, 14(2), 80; https://doi.org/10.3390/metabo14020080 - 23 Jan 2024
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Abstract
Lipids are a crucial component of the human brain, serving important structural and functional roles. They are involved in cell function, myelination of neuronal projections, neurotransmission, neural plasticity, energy metabolism, and neuroinflammation. Despite their significance, the role of lipids in the development of [...] Read more.
Lipids are a crucial component of the human brain, serving important structural and functional roles. They are involved in cell function, myelination of neuronal projections, neurotransmission, neural plasticity, energy metabolism, and neuroinflammation. Despite their significance, the role of lipids in the development of mental disorders has not been well understood. This review focused on the potential use of lipids as blood biomarkers for common mental illnesses, such as major depressive disorder, anxiety disorders, bipolar disorder, and schizophrenia. This review also discussed the impact of commonly used psychiatric medications, such as neuroleptics and antidepressants, on lipid metabolism. The obtained data suggested that lipid biomarkers could be useful for diagnosing psychiatric diseases, but further research is needed to better understand the associations between blood lipids and mental disorders and to identify specific biomarker combinations for each disease. Full article
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