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Medicina
Special Issues
Recent Advances in Lymphoedema Research
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Recent Advances in Lymphoedema Research

A special issue of Medicina (ISSN 1648-9144). This special issue belongs to the section "Surgery".

Deadline for manuscript submissions: 30 June 2025 | Viewed by 769

Special Issue Editors

Dr. Luigi Losco

E-Mail Website
Guest Editor
Plastic Surgery Unit, Department of Medicine, Surgery and Dentistry, University of Salerno, Via Salvador Allende, 43, Baronissi, 84081 Salerno, Italy
Interests: reconstructive surgery; lymphoedema; lymphatic surgery; lymph node transfer; free-flap surgery; perforator flaps; breast reconstruction; massive weight loss; post bariatric surgery; facial reconstruction
Special Issues, Collections and Topics in MDPI journals
Dr. Michela Schettino

E-Mail Website
Guest Editor Assistant
Unit of Plastic and Reconstructive Surgery, CHIREC de Braine L’Alleud Hospital, 1410 Brussels, Belgium
Interests: lymphoedema; lymphatic surgery; lymph node transfer; free-flap surgery; perforator flaps; breast reconstruction; massive weight loss; post bariatric surgery; facial reconstruction; facial reanimation

Special Issue Information

Dear Colleagues,

Lymphoedema remains a complex and challenging condition, often resistant to traditional treatments. With our deepening understanding of this disease, surgical interventions have become increasingly vital, especially for patients who have exhausted conservative options. Recent breakthroughs in microsurgery, supermicrosurgery, and lymphaticovenular anastomosis are transforming patient care, offering new possibilities for improved outcomes and an enhanced quality of life.

In this Medicina Special Issue, "Recent Advances in Lymphoedema Research", we aim to gather pioneering research and clinical insights that push the boundaries of what is possible in lymphoedema treatment. This issue will explore the latest surgical techniques, their practical applications, and their integration into comprehensive care plans, with a particular interest in studies addressing patient selection, perioperative strategies, and long-term outcomes.

By contributing your original research, reviews, and case studies to this Special Issue, you will have the opportunity to showcase your work to a global audience, helping shape the future of lymphoedema management, advancing this field, and contributing to the improvement of patient care worldwide.

Dr. Luigi Losco
Guest Editors

Dr. Michela Schettino
Guest Editor Assistant

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Medicina is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • lymphoedema
  • ultra-high-frequency ultrasound
  • ICG lymphography
  • breast cancer-related lymphoedema
  • lymphatic surgery
  • lymph node transfer
  • lymphaticovenular anastomosis
  • conservative treatment of lymphoedema
  • lymphoedema rehabilitation
  • health-related quality of life
  • supermicrosurgery

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Published Papers (1 paper)

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Research

12 pages, 10231 KiB  
Article
Gastroepiploic Vascularized Lymph Node Transfer for Extremity Lymphedema: Tips and Insights from Extensive Clinical Experience
by Mirco Pozzi, Davide Di Seclì, Alberto Bolletta, Emanuele Cigna, Chiara Camilloni, Beniamino Brunetti, Paolo Persichetti, Michela Schettino, Luigi Losco and Hung-Chi Chen
Medicina 2025, 61(3), 503; https://doi.org/10.3390/medicina61030503 - 15 Mar 2025
Viewed by 470
Abstract
Background and Objectives: Lymphedema is a chronic and progressive condition that leads to significant morbidity, including recurrent infections, fibrosis, and functional limitations. Conservative treatments often offer limited relief, particularly in severe cases. Vascularized lymph node transfer (VLNT), especially using the gastroepiploic lymph [...] Read more.
Background and Objectives: Lymphedema is a chronic and progressive condition that leads to significant morbidity, including recurrent infections, fibrosis, and functional limitations. Conservative treatments often offer limited relief, particularly in severe cases. Vascularized lymph node transfer (VLNT), especially using the gastroepiploic lymph node flap, has emerged as a promising intervention. This study evaluates the long-term outcomes of gastroepiploic VLNT combined with suction-assisted lipectomy (SAL) for extremity lymphedema. Materials and Methods: A retrospective review was conducted on 53 patients treated for lymphedema at our clinic in Taiwan from January 2016 to August 2023. The inclusion criteria required patients to have persistent lymphedema for at least six months despite conservative treatment. VLNT was performed using a laparoscopic approach, and postoperative assessments included limb circumference measurements, lymphoscintigraphy, and tonicity evaluations. Results: Follow-up data were collected for a minimum of 12 months. At a mean follow-up of 14.2 months, significant reductions in limb circumference were observed—35.5% ± 24.9% for upper limbs and 32.2% ± 4.5% for lower limbs. Tonicity improved by 6.2%, and no cellulitis episodes were reported post-surgery. Minor complications included hematoma and sensory changes, with no major donor-site morbidity. Lymphoscintigraphy confirmed improved lymphatic drainage. Conclusions: Gastroepiploic VLNT combined with SAL is an effective and safe treatment for severe extremity lymphedema, providing significant improvements in limb size and tissue tonicity. This technique offers a promising solution for refractory cases. Full article
(This article belongs to the Special Issue Recent Advances in Lymphoedema Research)
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