Hematologic Malignancies: Diagnosis, Prognosis and Management

A special issue of Medicina (ISSN 1648-9144). This special issue belongs to the section "Oncology".

Deadline for manuscript submissions: 1 May 2026 | Viewed by 165

Special Issue Editors


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Guest Editor
Department of Hematology, University of Debrecen, 4032 Debrecen, Hungary
Interests: follicular lymphoma; stem cell transplantation; prognostic factors

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Guest Editor
Division of Hematology, Department of Internal Medicine, Faculty of Medicine, University of Debrecen, Debrecen, Hungary
Interests: hematological malignancies; hematopathology; hodgkin lymphoma

Special Issue Information

Dear Colleagues,

Recent advances in molecular diagnostics, targeted therapies, and immunotherapies including CAR T-cells have profoundly reshaped the landscape of hematologic malignancy treatment. However, significant challenges remain, including therapeutic resistance, disease relapse, and the need for more personalized prognostic tools.

This Special Issue will collate cutting-edge research and clinical insights that address these critical areas. We will highlight the latest developments in the use of genomic and proteomic biomarkers for precision diagnosis and risk stratification, as well as novel therapeutic approaches and strategies for managing treatment-related toxicities. We also welcome submissions on the evolving role of minimal residual disease (MRD) monitoring and the integration of artificial intelligence in patient care pathways.

We invite high-quality original articles and comprehensive reviews that advance our understanding of hematologic malignancies. We look forward to receiving your valuable contributions to this vital field of medicine.

Dr. Ádám Jona
Dr. Zsófia Miltényi
Guest Editors

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Keywords

  • malignant lymphoma
  • treatment
  • prognostication
  • stem cell transplantation
  • cellular therapy

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Published Papers (1 paper)

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Research

13 pages, 983 KB  
Article
Adipokines as Prognostic Biomarkers in Multiple Myeloma: A Case–Control Study
by Nóra Obajed Al-Ali, Dóra Csige, László Imre Pinczés, Katalin Farkas, István Rebenku, Andrea Domján, György Panyi, Zoltán Szekanecz, Gabriella Szűcs, Árpád Illés and László Váróczy
Medicina 2025, 61(11), 2065; https://doi.org/10.3390/medicina61112065 - 20 Nov 2025
Viewed by 53
Abstract
Background and Objectives: Multiple myeloma (MM) remains an incurable plasma cell malignancy with heterogeneous clinical outcomes. Although current prognostic systems integrate biochemical and cytogenetic parameters, they do not fully capture disease complexity. Adipocytes within the bone marrow microenvironment secrete adipokines that regulate inflammation, [...] Read more.
Background and Objectives: Multiple myeloma (MM) remains an incurable plasma cell malignancy with heterogeneous clinical outcomes. Although current prognostic systems integrate biochemical and cytogenetic parameters, they do not fully capture disease complexity. Adipocytes within the bone marrow microenvironment secrete adipokines that regulate inflammation, metabolism, and immune interactions and may influence disease progression. This study aimed to assess circulating adipokines and related microenvironmental mediators as potential biomarkers of disease activity and treatment response in MM. Materials and Methods: In this case–control, cross-sectional study, the serum levels of eight adipokine-related molecules—adiponectin, leptin, resistin, chemerin, adipsin, thrombospondin-1 (TSP-1), paraoxonase-1 (PON-1), and myeloperoxidase (MPO)—were measured in 40 MM patients and 38 age- and sex-matched healthy controls. Enzyme-linked immunosorbent assays (ELISA) and bead-based multiplex immunoassays were used. Associations with prognostic markers (serum β2-microglobulin (sB2M), LDH, albumin, hemoglobin, renal function) and treatment response were analyzed using correlation and non-parametric statistical methods. Results: Compared to the controls, MM patients exhibited significantly higher circulating levels of adiponectin, resistin, chemerin, adipsin, TSP-1, and MPO, while leptin was decreased. Among clinical correlations, chemerin and PON-1 correlated positively with sB2M, TSP-1 correlated with LDH, and MPO correlated with M-protein and albumin. Resistin was lower in patients with renal impairment and an advanced disease stage. Adiponectin and TSP-1 were significantly lower in progressive disease compared to complete remission, suggesting their potential association with treatment response. Conclusions: This study demonstrates that multiple adipokines are dysregulated in MM and exhibit distinct associations with disease burden, renal function, and therapeutic response. Novel associations identified for TSP-1, PON-1, and adipsin highlight previously unrecognized microenvironmental pathways in MM biology. Adipokine profiling may complement established prognostic markers and provide new insights into the tumour microenvironment in MM. Full article
(This article belongs to the Special Issue Hematologic Malignancies: Diagnosis, Prognosis and Management)
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