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Medicina
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Advances in Colorectal Surgery and Oncology
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Advances in Colorectal Surgery and Oncology

A special issue of Medicina (ISSN 1648-9144). This special issue belongs to the section "Surgery".

Deadline for manuscript submissions: 30 August 2025 | Viewed by 699

Special Issue Editor

Dr. Jasneet Singh Bhullar

E-Mail Website
Guest Editor
Henry Ford Rochester Hospital, College of Human Medicine, Michigan State University, Rochester Hills, MI 48309, USA
Interests: colorectal surgery; robotic-assisted surgery; artificial intelligence (AI) in colonoscopy; organ preservation strategies; anorectal disease management

Special Issue Information

Dear Colleagues,

This Special Issue entitled “Advances in Colorectal Surgery and Oncology” brings together contemporary developments and transformative research to address key challenges and innovations in the field. It includes the evolution of minimally invasive surgery (MIS), such as robotic surgeries, and the integration of artificial intelligence (AI) into clinical practice, particularly in colonoscopy. Furthermore, it highlights significant advancements in rectal cancer surgery, including organ preservation strategies, total mesorectal excision (TME), and the adoption of enhanced recovery pathways. This Special Issue also explores innovations in the management of anorectal diseases, advances in pelvic floor disorders, and novel methods for the early detection and management of anal intraepithelial neoplasia (AIN).

It discusses the importance of tailored approaches for unique populations, including frail elderly patients who require individualized treatment plans that balance oncologic efficacy with quality of life. Additionally, the rising incidence of colorectal cancer in younger individuals underscores the need for genetic screening, risk factor identification, and targeted interventions.

By encompassing cutting-edge research, clinical innovations, and evidence-based guidelines, this Special Issue aims to foster collaboration among surgeons, oncologists, and researchers. It provides a platform for addressing contemporary challenges, disseminating technological advances, and promoting patient-centred care to improve outcomes in colorectal surgery and oncology.

Dr. Jasneet Singh Bhullar
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Medicina is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • colorectal surgery
  • robotic-assisted surgery
  • artificial intelligence (AI) in colonoscopy
  • organ preservation strategies
  • anorectal disease management

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (2 papers)

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Research

9 pages, 275 KiB  
Article
The Effect of Different Intraperitoneal Hyperthermic Chemotherapy (HIPEC) Regimens on Serum Electrolyte Levels: A Comparison of Oxaliplatin and Mitomycin C
by Vural Argın, Mehmet Ömer Özduman, Ahmet Orhan Sunar, Mürşit Dinçer, Aziz Serkan Senger, Selçuk Gülmez, Orhan Uzun, Mustafa Duman and Erdal Polat
Medicina 2025, 61(8), 1345; https://doi.org/10.3390/medicina61081345 - 25 Jul 2025
Viewed by 182
Abstract
Background and Objectives: This study aimed to compare the effects of HIPEC procedures using oxaliplatin and mitomycin C on serum electrolyte, glucose, and lactate levels, with a specific focus on the carrier solutions employed. Materials and Methods: A retrospective analysis was [...] Read more.
Background and Objectives: This study aimed to compare the effects of HIPEC procedures using oxaliplatin and mitomycin C on serum electrolyte, glucose, and lactate levels, with a specific focus on the carrier solutions employed. Materials and Methods: A retrospective analysis was performed on 82 patients who underwent cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (HIPEC) for colorectal peritoneal metastases. Patients were assigned to one of two groups based on the chemotherapeutic agent used: oxaliplatin (n = 63) or mitomycin C (MMC, n = 19). The oxaliplatin group was further subdivided based on the carrier solution used: 5% dextrose (D5W, n = 29) or peritoneal dialysate (n = 34). The assignment of regimens was based on institutional protocols and surgeon preference. Pre- and post-HIPEC serum levels of sodium, potassium, bicarbonate, glucose, and lactate were compared. Results: Significant biochemical changes were observed across groups, depending on both the chemotherapeutic agent and carrier solution. In the MMC group (peritoneal dialysate), only lactate increased significantly post-HIPEC (p = 0.001). In the oxaliplatin–peritoneal dialysate group, significant changes were observed in bicarbonate (p = 0.009), glucose (p = 0.001), and lactate (p < 0.001), whereas sodium and potassium remained stable. The oxaliplatin–D5W group showed significant changes in all parameters: sodium (p = 0.001), potassium (p = 0.001), bicarbonate (p = 0.001), glucose (p < 0.001), and lactate (2.4 → 7.6 mmol/L, p < 0.001). Between-group comparisons revealed significant differences in sodium, potassium, glucose, and lactate changes (p < 0.05), but not in bicarbonate (p = 0.099). Demographic and clinical characteristics—including age, sex, primary disease, ICU stay, and 90-day mortality were similar across groups. Conclusions: The use of dextrose-containing solutions with oxaliplatin was associated with marked metabolic disturbances, including clinically meaningful hyponatremia, hypokalemia, and hyperglycemia in the early postoperative period. These findings suggest that the choice of carrier solution is as important as the chemotherapeutic agent in terms of perioperative safety. Closer postoperative electrolyte monitoring is recommended when using dextrose-based regimens. The retrospective design and sample size imbalance between groups are acknowledged limitations. Nonetheless, this study offers clinically relevant insights and lays the groundwork for future prospective research. Full article
(This article belongs to the Special Issue Advances in Colorectal Surgery and Oncology)
14 pages, 4554 KiB  
Article
Local Pedicled Flaps and Biological Implant Options for Patients Undergoing Proctectomy for Crohn’s Disease When an Omental Pedicle Flap Is Not Possible
by Jacob Baxter, Ian S. Reynolds, Nho V. Tran, David W. Larson, Kellie L. Mathis and Nicholas P. McKenna
Medicina 2025, 61(7), 1153; https://doi.org/10.3390/medicina61071153 - 26 Jun 2025
Viewed by 242
Abstract
Background and Objectives: Perineal wound complications and pelvic fluid collections or abscesses following proctectomy for Crohn’s disease are a common cause of morbidity and might be mitigated by filling the pelvis and occluding the pelvic inlet with a flap. Alternative flap options can [...] Read more.
Background and Objectives: Perineal wound complications and pelvic fluid collections or abscesses following proctectomy for Crohn’s disease are a common cause of morbidity and might be mitigated by filling the pelvis and occluding the pelvic inlet with a flap. Alternative flap options can be considered when inadequate omentum is available and when avoiding myofasciocutaneous flaps. Materials and Methods: A retrospective review of our Crohn’s proctectomy database was conducted to identify patients who underwent a non-omental or non-myofasciocutaneous local pedicle flap to their pelvis or pelvic exclusion using biological material during surgery. The techniques and outcomes of these alternative techniques are described in detail. Results: 228 patients underwent proctectomy for Crohn’s disease during the 10-year study period. However, only six patients had their pelvis filled or pelvic inlet occluded using a non-omental, non-myofasciocutaneous local pedicled flap or biological material. The techniques identified included two sigmoid mesocolic flaps, one peritoneal, preperitoneal fat and falciform ligament flap, one perivesical fat flap, one Gerota’s fat pad flap, and one bovine pericardial patch assisted pelvic exclusion. These flaps’ clinicopathological and operative characteristics, surgical outcomes, and technical aspects are described. Conclusions: When greater omentum is unavailable or inadequate and myofasciocutaneous flaps need to be avoided, local pedicled flaps using a range of intra-abdominal tissues or biological material can be used to fill the pelvis or occlude the pelvic inlet after proctectomy for Crohn’s disease. These techniques may help to prevent short and long-term complications associated with having a pelvic dead space. Full article
(This article belongs to the Special Issue Advances in Colorectal Surgery and Oncology)
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