Infection, Inflammation and Immunity in Health and Disease

Dear Colleagues,

Humans are constantly exposed to various environmental agents, including but not limited to microbes. To overcome the deleterious actions of these environmental agents, the human body needs to have a robust immune system and a timely inflammation resolution capacity in order to maintain normal health and homeostasis. Thus, infection, inflammation, and immunity play a significant role in human health. Factors that regulate the body’s capacity to adequately deal with inflammation when needed and its resolution in a timely fashion, induce a robust immune response against microbes, and perform the appropriate repairs of the damage induced by various environmental agents need to be deciphered, understood and exploited in the prevention and management of various diseases. Some of the factors that are important in human health and disease include cytokines, eicosanoids, growth factors, adhesion molecules, etc., along with various genes that regulate their secretion and function. It is important to know how all of these endogenous molecules interact with each other in the regulation of infection, inflammation and immunity to maintain homeostasis. These factors have a fundamental role in metabolic, immunological, degenerative and genetic diseases across various subspecialties of medicine, such as rheumatology, cardiology, gastroenterology, genetics, oncology, endocrinology, nephrology, etc. Gene therapy, siRNA-based drugs, exosomes, immune check point inhibitors, and other modes of therapy may ultimately prove to be of value in several diseases. It is the purpose of this Special Issue to bridge the gap between the laboratory and the clinic and to highlight the advances in various areas that may have an impact on the prevention and management of various diseases including but not limited to infections, inflammation, immunological diseases, genetic diseases and inborn errors of metabolism and ageing. Coronary heart disease, atherosclerosis, hyperlipidemia, osteoarthritis and sarcopenia of senility are all considered as low-grade systemic inflammatory conditions.

This Special Issue aims to cover various aspects of infection, inflammation, and immunity applicable to various diseases/disorders. All types of manuscripts are welcome for publication in this Special Issue.

Prof. Dr. Das Undurti
Guest Editor

Manuscript Submission Information

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• infection
• inflammation
• immunity
• oncogenesis
• cancer
• autoimmunity
• ageing