New Regenerative Medicine Strategies in Oral Surgery

A special issue of Medicina (ISSN 1648-9144). This special issue belongs to the section "Dentistry and Oral Health".

Deadline for manuscript submissions: 25 September 2025 | Viewed by 511

Special Issue Editors


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Guest Editor
1. Maxillofacial Surgery and Dental Unit, Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy
2. Department of Biomedical, Surgical and Dental Sciences, University of Milan, Via della Commenda 10, 20122 Milan, Italy
Interests: dental

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Guest Editor Assistant
1. Department of Biomedical, Surgical and Dental Sciences, University of Milan, 20122 Milan, Italy
2. Implant Center for Edentulism and Jawbone Atrophies, Maxillofacial Surgery and Dental Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy
Interests: periodontal

E-Mail Website
Guest Editor Assistant
1. Maxillofacial Surgery and Dental Unit, Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy
2. Department of Biomedical, Surgical and Dental Sciences, University of Milan, Via della Commenda 10, 20122 Milan, Italy
Interests: oral surgery; oral pathology; laser surgery; prosthesis

Special Issue Information

Dear Colleagues,

Oral regenerative surgery is a rapidly evolving field at the intersection of clinical practice, biomaterial science, and tissue engineering. Over the last decades, significant advances have been made in the development of novel approaches to promoting healing and regeneration in oral tissues, with a particular focus on bone, soft tissues, and periodontal structures. These innovations are driving a paradigm shift in the management of oral pathologies from traditional methods of tissue repair to more sophisticated, biologically driven regenerative therapies. New materials, growth factors, stem cell-based strategies, and gene therapy techniques are transforming the landscape of oral surgery, offering more predictable outcomes and improved functional recovery.

This Special Issue will explore the latest research and clinical advancements in the field of oral regenerative surgery, highlighting new technologies and treatment modalities designed to enhance tissue regeneration, minimize patient morbidity, and reduce the need for grafting or prosthetic interventions. Possible topics include advances in 3D bioprinting, the use of scaffold materials and biologically active molecules, the role of stem cells in tissue regeneration, and the integration of regenerative techniques into complex reconstructive procedures. We will also address the emerging role of personalized medicine and regenerative approaches in addressing challenging conditions such as severe periodontitis, traumatic injuries, and congenital defects. The ultimate goal of these innovations is to improve long-term outcomes and quality of life for patients, underscoring the importance of interdisciplinary collaboration between clinicians, researchers, and engineers in pushing the boundaries of oral surgery.

Dr. Francesco Spadari
Guest Editor

Dr. Matteo Pellegrini
Dr. Federica Pulicari
Guest Editor Assistants

Manuscript Submission Information

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Keywords

  • oral surgery
  • oral pathology
  • laser surgery
  • photobiomodulation

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Published Papers (1 paper)

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Review

16 pages, 950 KiB  
Review
High Insertion Torque—Clinical Implications and Drawbacks: A Scoping Review
by Mattia Manfredini, Martina Ghizzoni, Beatrice Cusaro, Mario Beretta, Carlo Maiorana, Francisley Ávila Souza and Pier Paolo Poli
Medicina 2025, 61(7), 1187; https://doi.org/10.3390/medicina61071187 - 30 Jun 2025
Viewed by 340
Abstract
Implant primary stability is a prerequisite for obtaining osseointegration and clinical success. Insertion torque (IT) is measured during implant placement and is expressed in Ncm. It represents the quantification of the frictional force experienced by the implant as it progresses apically through a [...] Read more.
Implant primary stability is a prerequisite for obtaining osseointegration and clinical success. Insertion torque (IT) is measured during implant placement and is expressed in Ncm. It represents the quantification of the frictional force experienced by the implant as it progresses apically through a rotational motion along its axis. Usually, to achieve osseointegration, a value within the range of 20–40 Ncm is desirable. Below a threshold of 20 Ncm, implants have a decrease in survival rate, while implant stability is guaranteed above 20 Ncm. The main goal of this study was to evaluate whether high values of IT affect osseointegration, implant health, and healing, by highlighting the positive and negative effects of IT > 50 Ncm on peri-implant bone, soft tissues, and long-term stability. This scoping review considered randomized clinical trials, observational studies, and cohort studies. Studies failing to meet the predefined inclusion criteria were excluded from the analysis. The review process adhered to the Preferred Reporting Items for Scoping Reviews (PRISMA-ScR) guidelines. Ultimately, a total of 11 studies were included in the final synthesis. Based on the studies included, the literature suggests that high values of IT guarantee adequate primary stability and better osseointegration. However, high IT is significantly associated with greater marginal bone loss, depending on bone density. Accordingly, IT values > 50 Ncm may provoke greater compressive forces with a negative impact on the jawbone. An elevated strain on the bone can induce necrosis and ischemia, due to an alteration of circulation, which in turn is responsible for marginal bone loss and reduced osseointegration. Lack of osseointegration ultimately leads to an early implant failure. As concerns soft tissue recession, a higher decrease is measured in implants placed with high-insertion torque. Nonetheless, additional clinical trials are warranted to assess long-term outcomes, quantify the incidence of these complications, and explore the impact of emerging clinical variables. Full article
(This article belongs to the Special Issue New Regenerative Medicine Strategies in Oral Surgery)
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