Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
4.1
2.4
Journals
Medicina
Special Issues
New Regenerative Medicine Strategies in Oral Surgery
share announcement

New Regenerative Medicine Strategies in Oral Surgery

A special issue of Medicina (ISSN 1648-9144). This special issue belongs to the section "Dentistry and Oral Health".

Deadline for manuscript submissions: 31 August 2026 | Viewed by 4693

Special Issue Editors

Dr. Francesco Spadari

E-Mail Website
Guest Editor
1. Maxillofacial Surgery and Dental Unit, Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy
2. Department of Biomedical, Surgical and Dental Sciences, University of Milan, Via della Commenda 10, 20122 Milan, Italy
Interests: dental
Dr. Matteo Pellegrini

E-Mail Website
Guest Editor Assistant
1. Department of Biomedical, Surgical and Dental Sciences, University of Milan, 20122 Milan, Italy
2. Implant Center for Edentulism and Jawbone Atrophies, Maxillofacial Surgery and Dental Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy
Interests: periodontal
Dr. Federica Pulicari

E-Mail Website
Guest Editor Assistant
1. Maxillofacial Surgery and Dental Unit, Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy
2. Department of Biomedical, Surgical and Dental Sciences, University of Milan, Via della Commenda 10, 20122 Milan, Italy
Interests: oral surgery; oral pathology; laser surgery; prosthesis

Special Issue Information

Dear Colleagues,

Oral regenerative surgery is a rapidly evolving field at the intersection of clinical practice, biomaterial science, and tissue engineering. Over the last decades, significant advances have been made in the development of novel approaches to promoting healing and regeneration in oral tissues, with a particular focus on bone, soft tissues, and periodontal structures. These innovations are driving a paradigm shift in the management of oral pathologies from traditional methods of tissue repair to more sophisticated, biologically driven regenerative therapies. New materials, growth factors, stem cell-based strategies, and gene therapy techniques are transforming the landscape of oral surgery, offering more predictable outcomes and improved functional recovery.

This Special Issue will explore the latest research and clinical advancements in the field of oral regenerative surgery, highlighting new technologies and treatment modalities designed to enhance tissue regeneration, minimize patient morbidity, and reduce the need for grafting or prosthetic interventions. Possible topics include advances in 3D bioprinting, the use of scaffold materials and biologically active molecules, the role of stem cells in tissue regeneration, and the integration of regenerative techniques into complex reconstructive procedures. We will also address the emerging role of personalized medicine and regenerative approaches in addressing challenging conditions such as severe periodontitis, traumatic injuries, and congenital defects. The ultimate goal of these innovations is to improve long-term outcomes and quality of life for patients, underscoring the importance of interdisciplinary collaboration between clinicians, researchers, and engineers in pushing the boundaries of oral surgery.

Dr. Francesco Spadari
Guest Editor

Dr. Matteo Pellegrini
Dr. Federica Pulicari
Guest Editor Assistants

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Medicina is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • oral surgery
  • oral pathology
  • laser surgery
  • photobiomodulation

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (3 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

Jump to: Review

17 pages, 6549 KB  
Article
Horizontal Bone Augmentation with Natural Collagen Porcine Pericardium Membranes: A Prospective Cohort Study
by Pier Paolo Poli, Luca Giboli, Mattia Manfredini, Shahnavaz Khijmatgar, Francisley Ávila Souza and Carlo Maiorana
Medicina 2025, 61(10), 1814; https://doi.org/10.3390/medicina61101814 - 10 Oct 2025
Cited by 1 | Viewed by 672
Abstract
Background and Objectives: Adequate buccal bone thickness is critical for long-term peri-implant health and stability. When residual alveolar bone volume is insufficient, guided bone regeneration (GBR) is a widely adopted technique. While non-resorbable membranes provide structural support, they carry a higher risk [...] Read more.
Background and Objectives: Adequate buccal bone thickness is critical for long-term peri-implant health and stability. When residual alveolar bone volume is insufficient, guided bone regeneration (GBR) is a widely adopted technique. While non-resorbable membranes provide structural support, they carry a higher risk of complications and require secondary surgery. Resorbable collagen membranes, offer promising biological properties and easier clinical handling, yet clinical data remain limited. This prospective cohort study aimed to evaluate the clinical and radiographic outcomes of horizontal GBR using a native, non–cross-linked resorbable porcine pericardium membrane fixed with titanium pins, in conjunction with simultaneous implant placement. Materials and Methods: Eighteen patients (26 implants) with horizontal alveolar defects (<6 mm) underwent implant placement and GBR with deproteinized bovine bone mineral and a porcine pericardium collagen membrane. Horizontal bone gain and buccal bone thickness were measured at baseline and 6 months post-operatively. Post-operative complications, patient-reported outcomes (PROMs), and peri-implant tissue health were assessed up to 1 year post-loading. Results: Mean bone gain was 2.95 ± 0.95 mm, and all sites achieved a buccal bone thickness ≥ 1.5 mm. No membrane-related complications occurred. PROMs revealed low morbidity. At 1-year follow-up, marginal bone loss averaged 0.54 ± 0.7 mm, mean probing depth was 2.79 ± 0.78 mm, 92% of sites exhibited keratinized mucosa ≥ 2 mm. Conclusions: Native resorbable porcine pericardium membranes, when combined with DBBM and mechanical stabilization, seem to be effective for horizontal bone regeneration. Full article
(This article belongs to the Special Issue New Regenerative Medicine Strategies in Oral Surgery)
►▼ Show Figures

Figure 1

Review

Jump to: Research

14 pages, 629 KB  
Review
Use of Laser in Periodontal Tissue Regeneration: A Scoping Review of Clinical and Experimental Evidence
by Martina Bosisio, Umberto Romeo, Alessandro Del Vecchio and Aldo Bruno Giannì
Medicina 2025, 61(12), 2199; https://doi.org/10.3390/medicina61122199 - 12 Dec 2025
Viewed by 325
Abstract
Background and Objectives: Periodontitis leads to progressive destruction of periodontal tissues and, despite advances in regenerative approaches, clinical outcomes remain inconsistent. Lasers have been proposed as adjuncts in regenerative periodontology because of their antimicrobial, hemostatic, and photobiomodulatory properties. However, available evidence remains [...] Read more.
Background and Objectives: Periodontitis leads to progressive destruction of periodontal tissues and, despite advances in regenerative approaches, clinical outcomes remain inconsistent. Lasers have been proposed as adjuncts in regenerative periodontology because of their antimicrobial, hemostatic, and photobiomodulatory properties. However, available evidence remains heterogeneous. This scoping review aims to systematically map clinical and experimental evidence on the role of lasers in periodontal tissue regeneration. Materials and Methods: The review was conducted in accordance with the PRISMA-ScR guidelines. PubMed, Scopus, and Web of Science were searched up to September 2025 without time restrictions. Eligible studies included in vitro, ex vivo, in vivo and clinical research assessing the application of lasers for periodontal healing. Reviews, conference abstracts and studies unrelated to regeneration were excluded. Results: The electronic search retrieved 314 records, of which 193 unique articles were screened after duplicates removal and 17 full texts were assessed. A total of 15 studies met the eligibility criteria and were included in the review. Included studies comprised 5 in vitro investigations, 2 ex vivo studies, 1 in vivo animal study, 4 case reports and 3 RCTs, published between 2015 and 2025. In vitro and ex vivo evidence demonstrated that laser irradiation enhanced cell proliferation, differentiation, growth factor release, and root surface conditioning. The in vivo study confirmed increased angiogenesis and bone formation after Er:YAG PBM. Clinical studies, including RCTs and case reports, reported improvements in PD reduction, clinical attachment gain, and radiographic bone fill, particularly when lasers were applied as adjuncts to regenerative techniques or biomaterials. Conclusions: Available evidence suggests that lasers can positively modulate biological processes and enhance the outcomes of regenerative periodontal procedures. However, the limited number of high-quality clinical trials, variability in laser types and parameters, and heterogeneity in protocols limit the strength of current conclusions. Further standardized RCTs with long-term follow-up are needed to clarify the clinical relevance of lasers in periodontal regenerative outcomes. Full article
(This article belongs to the Special Issue New Regenerative Medicine Strategies in Oral Surgery)
►▼ Show Figures

Figure 1

16 pages, 950 KB  
Review
High Insertion Torque—Clinical Implications and Drawbacks: A Scoping Review
by Mattia Manfredini, Martina Ghizzoni, Beatrice Cusaro, Mario Beretta, Carlo Maiorana, Francisley Ávila Souza and Pier Paolo Poli
Medicina 2025, 61(7), 1187; https://doi.org/10.3390/medicina61071187 - 30 Jun 2025
Cited by 4 | Viewed by 3307
Abstract
Implant primary stability is a prerequisite for obtaining osseointegration and clinical success. Insertion torque (IT) is measured during implant placement and is expressed in Ncm. It represents the quantification of the frictional force experienced by the implant as it progresses apically through a [...] Read more.
Implant primary stability is a prerequisite for obtaining osseointegration and clinical success. Insertion torque (IT) is measured during implant placement and is expressed in Ncm. It represents the quantification of the frictional force experienced by the implant as it progresses apically through a rotational motion along its axis. Usually, to achieve osseointegration, a value within the range of 20–40 Ncm is desirable. Below a threshold of 20 Ncm, implants have a decrease in survival rate, while implant stability is guaranteed above 20 Ncm. The main goal of this study was to evaluate whether high values of IT affect osseointegration, implant health, and healing, by highlighting the positive and negative effects of IT > 50 Ncm on peri-implant bone, soft tissues, and long-term stability. This scoping review considered randomized clinical trials, observational studies, and cohort studies. Studies failing to meet the predefined inclusion criteria were excluded from the analysis. The review process adhered to the Preferred Reporting Items for Scoping Reviews (PRISMA-ScR) guidelines. Ultimately, a total of 11 studies were included in the final synthesis. Based on the studies included, the literature suggests that high values of IT guarantee adequate primary stability and better osseointegration. However, high IT is significantly associated with greater marginal bone loss, depending on bone density. Accordingly, IT values > 50 Ncm may provoke greater compressive forces with a negative impact on the jawbone. An elevated strain on the bone can induce necrosis and ischemia, due to an alteration of circulation, which in turn is responsible for marginal bone loss and reduced osseointegration. Lack of osseointegration ultimately leads to an early implant failure. As concerns soft tissue recession, a higher decrease is measured in implants placed with high-insertion torque. Nonetheless, additional clinical trials are warranted to assess long-term outcomes, quantify the incidence of these complications, and explore the impact of emerging clinical variables. Full article
(This article belongs to the Special Issue New Regenerative Medicine Strategies in Oral Surgery)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-3
Back to TopTop