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Medicina
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Latest Advances in Regional Anesthesia
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Latest Advances in Regional Anesthesia

A special issue of Medicina (ISSN 1648-9144). This special issue belongs to the section "Intensive Care/ Anesthesiology".

Deadline for manuscript submissions: closed (31 January 2024) | Viewed by 10595

Special Issue Editors

Dr. Zhirajr Mokini

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Guest Editor
Independent Researcher, European Society of Anaesthesiology and Intensive Care Mentorship Programme, B-1000 Brussels, Belgium
Interests: perioperative medicine
Prof. Dr. Patrice Forget

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Guest Editor
NHS Grampian, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK
Interests: perioperative medicine; anesthesiology; acute pain; chronic pain; pain management; inflammation; postoperative outcomes; opioids
Special Issues, Collections and Topics in MDPI journals
Dr. Lucillia Bezu

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Guest Editor
Anesthesiology and Intensive Care Department, U1138 Metabolism, Cancer and Immunity (G. Kroemer lab), 39 rue Camille Desmoulins, 94805 Villejuif, France
Interests: metabolism; cellular and molecular biology; cell signaling; cell death modality; epigenetic; cancer; immunity; oncoimmunology; anesthesiology; intensive care
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Regional anaesthesia has always been a fundamental option in pain management. The advent of new anaesthetics and ultrasound guidance has permitted an increased diffusion of regional anaesthesia among practitioners and its integration into a multimodal strategy pain management strategy. As a consequence, we have also gained deeper knowledge of anatomy and diffusion kinetics after anaesthetic blocs and new techniques are being increasingly developed.

This Special Issue is dedicated to regional anaesthesia and will include the following topics:

  • Acute pain and perioperative medicine,
  • Oncoanaesthesia,
  • Chronic pain,
  • Intensive care, 
  • Emergency pain,
  • Pediatric pain,
  • Anatomy and techniques, 
  • Pharmacology;
  • Education.

We welcome the following types of articles:

  • Epidemiologic studies,
  • Meta-analyses, 
  • Systematic reviews, 
  • Original articles,
  • Case reports;
  • Pharmacology studies.

Dr. Zhirajr Mokini
Prof. Dr. Patrice Forget
Dr. Lucillia Bezu
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Medicina is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • regional anesthesia
  • local anesthetic
  • block
  • chronic pain
  • acute pain
  • cancer
  • surgery

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (3 papers)

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Research

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16 pages, 1434 KiB  
Article
Impact of Surgical and Anesthetic Procedures after Colorectal Cancer Surgery: A Propensity Score-Matched Cohort Study (The PROCOL Study)
by Céline Kuoch and Lucillia Bezu
Medicina 2024, 60(8), 1362; https://doi.org/10.3390/medicina60081362 - 21 Aug 2024
Viewed by 1290
Abstract
Background: Surgical inflammatory pain decreases the innate and adaptive immune antitumor response and favors residual circulating tumor cells. Objectives: This study investigated whether minimally invasive surgeries (laparoscopic and robotic procedures), which are less painful and inflammatory, improved oncological outcomes after colorectal resection compared [...] Read more.
Background: Surgical inflammatory pain decreases the innate and adaptive immune antitumor response and favors residual circulating tumor cells. Objectives: This study investigated whether minimally invasive surgeries (laparoscopic and robotic procedures), which are less painful and inflammatory, improved oncological outcomes after colorectal resection compared to laparotomy. Methods: This research was a single-center propensity score-matched study involving patients who underwent colectomy and rectum resection from July 2017 to December 2019. Results: Seventy-four laparotomies and 211 minimally invasive procedures were included. Minimally invasive procedures were associated with less blood loss (0 mL vs. 75 mL, p < 0.001), shorter length of stay (8 days vs. 12 days, p < 0.001), and fewer complications at 3 months (11.8% vs. 29.4%, p = 0.02) compared to laparotomies. No difference in overall survival (OS) and recurrence-free survival (RFS) at 3 years between groups was observed. Univariate Cox regression analyses demonstrated that age and ASA > 3 can negatively impact OS, while adjuvant chemotherapy can positively influence OS. pT3-T4 stage and postoperative pain could negatively influence RFS. Multivariate Cox regression analyses concluded that age (HR 1.08, p < 0.01) and epidural analgesia (HR 0.12, p = 0.03) were predictors for OS. Lidocaine infusion (HR 0.39, p = 0.04) was a positive predictor for RFS. Conclusions: Minimally invasive procedures reduce postoperative complications and shorten the length of hospital stay compared to major surgeries without improving prognosis. However, the administration of local anesthetics through neuraxial anesthesia or intravenous infusion could improve survival and decrease the occurrence of relapses. Full article
(This article belongs to the Special Issue Latest Advances in Regional Anesthesia)
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12 pages, 1598 KiB  
Article
Pain Control for Sickle Cell Crisis, a Novel Approach? A Retrospective Study
by Amélie Rollé, Elsa Vidal, Pierre Laguette, Yohann Garnier, Delphine Delta, Frédéric Martino, Patrick Portecop, Maryse Etienne-Julan, Pascale Piednoir, Audrey De Jong, Marc Romana and Emmanuelle Bernit
Medicina 2023, 59(12), 2196; https://doi.org/10.3390/medicina59122196 - 18 Dec 2023
Cited by 3 | Viewed by 3196
Abstract
Background and Objectives: Pain management poses a significant challenge for patients experiencing vaso-occlusive crisis (VOC) in sickle cell disease (SCD). While opioid therapy is highly effective, its efficacy can be impeded by undesirable side effects. Local regional anesthesia (LRA), involving the deposition [...] Read more.
Background and Objectives: Pain management poses a significant challenge for patients experiencing vaso-occlusive crisis (VOC) in sickle cell disease (SCD). While opioid therapy is highly effective, its efficacy can be impeded by undesirable side effects. Local regional anesthesia (LRA), involving the deposition of a perineural anesthetic, provides a nociceptive blockade, local vasodilation and reduces the inflammatory response. However, the effectiveness of this therapeutic approach for VOC in SCD patients has been rarely reported up to now. The objective of this study was to assess the effectiveness of a single-shot local regional anesthesia (LRA) in reducing pain and consequently enhancing the management of severe vaso-occlusive crisis (VOC) in adults with sickle cell disease (SCD) unresponsive to conventional analgesic therapy. Materials and Methods: We first collected consecutive episodes of VOC in critical care (ICU and emergency room) for six months in 2022 in a French University hospital with a large population of sickle cell patients in the West Indies population. We also performed a systematic review of the use of LRA in SCD. The primary outcome was defined using a numeric pain score (NPS) and/or percentage of change in opioid use. Results: We enrolled nine SCD adults (28 years old, 4 females) for ten episodes of VOC in whom LRA was used for pain management. Opioid reduction within the first 24 h post block was −75% (50 to 96%). Similarly, the NPS decreased from 9/10 pre-block to 0–1/10 post-block. Five studies, including one case series with three patients and four case reports, employed peripheral nerve blocks for regional anesthesia. In general, local regional anesthesia (LRA) exhibited a reduction in pain and symptoms, along with a decrease in opioid consumption post-procedure. Conclusions: LRA improves pain scores, reduces opioid consumption in SCD patients with refractory pain, and may mitigate opioid-related side effects while facilitating the transition to oral analgesics. Furthermore, LRA is a safe and effective procedure. Full article
(This article belongs to the Special Issue Latest Advances in Regional Anesthesia)
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Review

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13 pages, 878 KiB  
Review
Latest Advances in Regional Anaesthesia
by Frances Fallon, Aneurin Moorthy, Conor Skerritt, Gillian G. Crowe and Donal J. Buggy
Medicina 2024, 60(5), 735; https://doi.org/10.3390/medicina60050735 - 28 Apr 2024
Cited by 5 | Viewed by 5138
Abstract
Training and expertise in regional anaesthesia have increased significantly in tandem with increased interest over the past two decades. This review outlines the most recent advances in regional anaesthesia and focuses on novel areas of interest including fascial plane blocks. Pharmacological advances in [...] Read more.
Training and expertise in regional anaesthesia have increased significantly in tandem with increased interest over the past two decades. This review outlines the most recent advances in regional anaesthesia and focuses on novel areas of interest including fascial plane blocks. Pharmacological advances in the form of the prolongation of drug duration with liposomal bupivacaine are considered. Neuromodulation in the context of regional anaesthesia is outlined as a potential future direction. The growing use of regional anaesthesia outside of the theatre environment and current thinking on managing the rebound plane after regional block regression are also discussed. Recent relevant evidence is summarised, unanswered questions are outlined, and priorities for ongoing investigation are suggested. Full article
(This article belongs to the Special Issue Latest Advances in Regional Anesthesia)
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