Systematic Reviews and Outcomes Research in Emergency Medicine

A special issue of Medicina (ISSN 1648-9144). This special issue belongs to the section "Intensive Care/ Anesthesiology".

Deadline for manuscript submissions: 30 May 2026 | Viewed by 456

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Guest Editor

Special Issue Information

Dear Colleagues,

Emergency medicine is a dynamic and high-stakes field, where clinical decisions are made under intense time pressure and with limited information. Historically, many interventions in emergency care have been guided by clinical intuition or local protocols rather than high-quality evidence. In recent years, systematic reviews and outcomes research have emerged as essential tools to consolidate available data, assess the effectiveness of interventions, and drive evidence-based practice across emergency departments worldwide.

This Special Issue will discuss and share new research at the interface of systematic evidence synthesis and real-world outcomes in emergency medicine. We wish to foster an understanding of the impacts of emergency care in patient-centered outcomes through the use of structured evidence to inform clinical decisions via improved protocols and appropriate policies.

This Special Issue will explore and disseminate cutting-edge research at the intersection of systematic evidence synthesis and real-world outcomes in emergency medicine. Our goal is to promote a deeper understanding of how emergency care influences patient-centered outcomes and how structured evidence can inform clinical decisions, improve protocols, and shape policy.

We welcome systematic reviews, meta-analyses, scoping reviews, methodological studies, and original investigations pertaining to the outcomes of patients in emergency care settings or pertaining to any aspect of healthcare or quality of care in emergency medicine. In the true spirit of international, multidisciplinary scientific inquiry, we invite you to contribute your perspectives for inclusion in this Special Issue.

Prof. Dr. Ovidiu Alexandru Mederle
Guest Editor

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Keywords

  • emergency department
  • critical illness
  • risk stratification
  • quality of care
  • patient outcomes
  • evidence-based practice
  • clinical decision-making
  • resuscitation
  • telemedicine in emergency care
  • emergency medical services

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Published Papers (1 paper)

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Research

14 pages, 857 KB  
Article
Insights into the Use of Erythrocyte and Platelet Distribution Indices for Assessing the Extent of Coronary Lesions
by Andrei-Catalin Zavragiu, Dumitru Sutoi, Oana-Raluca Radbea, Bogdan Chiu, Diana-Evelyne Mailat, Samuel Ardelean, Petre-Adrian Barzache, Ionut Dudau, Ovidiu-Alexandru Mederle and Minodora Andor
Medicina 2025, 61(11), 1939; https://doi.org/10.3390/medicina61111939 - 29 Oct 2025
Viewed by 306
Abstract
Background/Objectives: Red cell distribution width, platelet distribution width, and mean platelet volume are hematological indices derived from complete blood counts that have been increasingly investigated as potential cardiovascular biomarkers. This study aimed to assess the association between these indices and the extent [...] Read more.
Background/Objectives: Red cell distribution width, platelet distribution width, and mean platelet volume are hematological indices derived from complete blood counts that have been increasingly investigated as potential cardiovascular biomarkers. This study aimed to assess the association between these indices and the extent of coronary artery disease, quantified by the Gensini score. Methods: We conducted a retrospective observational study of 240 patients hospitalized with typical angina who underwent elective coronary angiography at the Institute of Cardiovascular Diseases in Timișoara (January 2023–April 2024). Patients with hematological disorders, prior revascularization, or severe comorbidities were excluded. CAD severity was assessed by the Gensini score, with patients stratified into a low-score group (<50) and a high-score group (≥50). Laboratory and echocardiographic data were collected. Correlation analyses, ROC curve analysis, and multivariate regression were performed to evaluate predictors of CAD complexity. Results: Among 240 patients (81% male), 161 (67%) were in the high-score group. Compared with the low-score group, these patients had higher RDW (12.43 ± 0.68 vs. 12.70 ± 1.01, 95%CI: −0.52 to −0.02, p = 0.03), MPV (9.20 ± 0.88 vs. 9.45 ± 0.84, 95%CI: −0.48 to −0.02, p = 0.03), serum creatinine (p = 0.01), and potassium (p = 0.02), and lower ejection fraction (p < 0.001). RDW correlated positively with the Gensini score (rho = 0.28, 95%CI: 0.16–0.39, p = 0.001). Multivariate analysis identified RDW, MPV, and diastolic dysfunction as independent predictors. RDW showed weak discrimination for high Gensini burden (AUC = 0.57, 95% CI: 0.49–0.65, p > 0.05), consistent with a borderline, non-significant result. Conclusions: Elevated RDW and MPV are independently associated with greater coronary lesion burden. These routinely available indices may serve as novel, cost-effective markers for CAD risk stratification, warranting validation in prospective studies. Full article
(This article belongs to the Special Issue Systematic Reviews and Outcomes Research in Emergency Medicine)
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