New Treatment Strategies for Chronic Kidney Disease
A special issue of Medicina (ISSN 1648-9144). This special issue belongs to the section "Urology & Nephrology".
Deadline for manuscript submissions: closed (30 November 2023) | Viewed by 278
Special Issue Editor
Special Issue Information
Dear Colleagues,
Chronic kidney disease (CKD) affects around 10% of adults and continues to grow due to the continuous onset of obesity and diabetes. CKD is a significant risk factor for cardiovascular morbidity and mortality. Current treatment strategies include targeting blood pressure and albuminuria, avoiding nephrotoxins, and reducing cardiovascular risk. However, the number of patients reaching end-stage kidney disease (ESKD) is still increasing, although the death rate is high. Nephrology is a fast-moving science, such is the example of new treatments for diabetic kidney disease (DKD), including renin–angiotensin system blockers, sodium–glucose cotransport inhibitors (SGLT2i), and mineralocorticoid receptor antagonists (MRA). Furthermore, research has shown a strong rationale for SGLT2 inhibition to be used as a standard of care for most CKD patients, including those with non-diabetic kidney disease. Recent studies have shown that inflammation, myofibroblast activation, tissue hypoxia, cell loss, and extracellular matrix deposition lead to CKD. The translation of these findings from bench to bedside can improve the efficacy of treatments for CKD.
Nowadays, the development of effective therapies for CKD is an ongoing challenge, and the focus of this Special Issue is to cover all new lines of treatment for CKD, including regenerative therapies. By reflecting on the current state of knowledge in this area, the issue aims to contribute to a better understanding of the molecular mechanisms involved in CKD progression and how these can be targeted to slow or halt the progression of the disease. Ultimately, these advancements can improve the quality of life of patients with CKD and reduce the burden of this disease on healthcare systems worldwide.
Prof. Dr. Goce Spasovski
Guest Editor
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Keywords
- chronic kidney disease
- diabetes kidney disease
- albuminuria
- acidosis
- inflammation
- cardiovascular risk
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