Acute Myocarditis: Prevention, Diagnosis and Treatment
A special issue of Medicina (ISSN 1648-9144). This special issue belongs to the section "Cardiology".
Deadline for manuscript submissions: 20 February 2027 | Viewed by 42
Editor
Special Issue Information
Dear Colleagues,
Myocarditis, in its acute and chronic forms, encompasses a broad clinical spectrum, extending from transient inflammatory injury to the development of chronic inflammatory cardiomyopathy characterized by persistent myocardial inflammation, ventricular remodeling and irreversible progression to dilated cardiomyopathy. Recent European Society of Cardiology (2025) and American College of Cardiology (2024) guidelines have further refined this continuum, emphasizing early recognition, standardized diagnostic pathways and the integration of multimodality imaging with histological, immunological and molecular profiling.
Advances in diagnostic precision—including high‑resolution cardiac magnetic resonance, optimized endomyocardial biopsy protocols and immunophenotyping—have improved the ability to differentiate viral and immune‑mediated/autoimmune forms. In this context, the recently proposed Seaport criteria offer a structured framework for the diagnosis of lymphocytic myocarditis, integrating clinical features with definite histological and immunohistochemical findings to enhance diagnostic consistency across centers.
Despite these advances, early disease recognition remains challenging due to the nonspecific nature of symptoms and biomarkers. Improving diagnostic algorithms is essential to reduce delays in care and identify patients at risk of progression toward chronic inflammatory cardiomyopathy. At the same time, growing evidence supports a shift toward targeted treatment strategies, including immunosuppression in selected immune‑mediated forms and emerging mechanism‑based therapies currently under investigation.
This Special Issue aims to provide an updated, comprehensive overview of myocarditis across its full clinical spectrum, with a focus on clinical features, diagnostic aspects and personalized treatments. By integrating clinical, imaging, molecular and immunological perspectives, it seeks to advance the field toward a more precise, etiology‑oriented approach to the diagnosis and management of myocarditis.
Dr. Andrea Silvio Giordani
Guest Editor
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Keywords
- myocarditis
- inflammatory cardiomyopathy
- cardiac magnetic resonance
- endomyocardial biopsy
- immunosuppressive therapy
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