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Medicina
Special Issues
New Research on Endodontic Therapy
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New Research on Endodontic Therapy

A special issue of Medicina (ISSN 1648-9144). This special issue belongs to the section "Dentistry and Oral Health".

Deadline for manuscript submissions: 30 June 2026 | Viewed by 3958

Special Issue Editors

Dr. António Ginjeira

E-Mail Website
Guest Editor
Faculdade de Medicina Dentária, Universidade de Lisboa, 1600-277 Lisboa, Portugal
Interests: endodontics; endodontology; dentistry; microsurgery
Dr. Abayomi Omokeji Baruwa

E-Mail Website
Guest Editor Assistant
Faculdade de Medicina Dentária, Universidade de Lisboa, 1600-277 Lisboa, Portugal
Interests: endodontics; dental medicine

Special Issue Information

Dear Colleagues,

Over the past decade, we have witnessed significant progress in terms of research and treatment protocols, innovative materials, and techniques in the field of endodontics and endodontic microsurgery, ranging from intracanal medications, irrigating solutions, sealers, microsurgery materials, and nickel–titanium files to cutting-edge equipment like microscopes and cone beam computed tomography with dynamic navigation tools. These introductions have advanced the landscape of treatments, prompting clinicians to adapt their workflows and develop new protocols, ultimately enhancing the standard of care provided to patients.

This Special Issue endeavors to present a comprehensive overview of the recent research and applications of these materials and equipment. The scope of this Special Issue is intentionally broad, encompassing a diverse array of topics and perspectives within the realm of endodontics and endodontic microsurgery. This includes not only vital and non-vital pulp therapies but also extends to areas such as endodontic microsurgery, intentional replantation, education and research, and complex interdisciplinary strategies involving prosthodontics, periodontology, and orthodontics, such as crown lengthening, orthodontic extrusion, and intricate restorations.

It is with great pleasure that I extend an invitation to you to contribute to this Special Issue. We welcome submissions of clinical research and reviews that will further enrich the discourse and advance our understanding of these transformative developments in endodontic and restorative practices.

Dr. António Ginjeira
Guest Editor

Dr. Abayomi Omokeji Baruwa
Guest Editor Assistant

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Medicina is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • endodontics
  • root canal therapy
  • root anatomy
  • pulp therapy
  • endodontic microsurgery
  • education
  • rotary endodontics

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (2 papers)

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Research

13 pages, 2013 KB  
Article
Evaluation of the Effectiveness of MicroMega Remover, ProTaper Universal Retreatment, Reciproc, and Hedstrom Files in the Retreatment of Curved Root Canals Obturated with Different Techniques: A Micro-Computed Tomography Study
by Pınar Hava Dursun, Fatma Semra Sevimay, Arda Buyuksungur and Berkan Celikten
Medicina 2026, 62(1), 188; https://doi.org/10.3390/medicina62010188 - 16 Jan 2026
Viewed by 660
Abstract
Background and Objectives: The anatomically demanding structure of curved root canals increases the technical difficulty of retreatment procedures. This study aimed to evaluate the retreatment efficacy of various rotary and reciprocating instruments in curved root canals obturated with cold and warm techniques [...] Read more.
Background and Objectives: The anatomically demanding structure of curved root canals increases the technical difficulty of retreatment procedures. This study aimed to evaluate the retreatment efficacy of various rotary and reciprocating instruments in curved root canals obturated with cold and warm techniques regarding root canal filling material removal, apical transportation, and retreatment time. Materials and Methods: Sixty-four curved mesial root canals of mandibular molars with Vertucci type IV morphology were prepared using the ProTaper Gold system and obturated with AH Plus sealer using either the single-cone (SC) (n = 32) or continuous wave vertical compaction (CWC) (n = 32) technique. Each group was divided into four subgroups (n = 8) and retreated using MicroMega Remover (MM Remover), ProTaper Universal Retreatment (PTUR), Reciproc (Rec), and Hedstrom file systems. Micro-computed tomography was used to assess residual filling material volume and apical transportation. The time required for retreatment was recorded. The level of statistical significance was set at p < 0.05. Results: Across both obturation techniques, the MM Remover and PTUR groups demonstrated shorter retreatment times compared with the CWC–Hedstrom group (p < 0.05). No statistically significant differences were observed among the file systems in terms of filling material removal and apical transportation (p > 0.05). Conclusions: All tested instruments effectively preserved root canal anatomy within clinically acceptable apical transportation limits. The MM Remover and PTUR systems achieved significantly shorter retreatment times, indicating clinical advantages in efficiency. None of the evaluated systems achieved complete removal of the filling materials in either obturation technique. This study provides one of the first comparative evaluations of the MM Remover system, supporting its applicability in complex canal configurations. Full article
(This article belongs to the Special Issue New Research on Endodontic Therapy)
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17 pages, 4200 KB  
Article
Enhancing Endodontic Outcomes with the Synergistic Microbicidal and Activated Root-Cleansing Technique (SMART): A Novel Approach to Root Canal Irrigation
by Max Foroughi, Sara Abolmaali, Hamid Abedi and Theodore Ravenel
Medicina 2025, 61(5), 874; https://doi.org/10.3390/medicina61050874 - 9 May 2025
Cited by 2 | Viewed by 2337
Abstract
Background and Objectives: Successful endodontic treatment requires thorough disinfection and removal of the smear layer to prevent reinfection. However, conventional irrigants like sodium hypochlorite (NaOCl) and ethylenediaminetetraacetic acid (EDTA) can compromise dentin integrity. This study assessed the efficacy of the Synergistic Microbicidal [...] Read more.
Background and Objectives: Successful endodontic treatment requires thorough disinfection and removal of the smear layer to prevent reinfection. However, conventional irrigants like sodium hypochlorite (NaOCl) and ethylenediaminetetraacetic acid (EDTA) can compromise dentin integrity. This study assessed the efficacy of the Synergistic Microbicidal and Ablative Root canal Technique (SMART), which integrates AromaRoot, a biocompatible irrigation solution based on quaternary ammonium compounds, with 980 nm diode laser activation, to enhance bacterial reduction and smear layer removal. Materials and Methods: Sixty extracted single-rooted human teeth were inoculated with Enterococcus faecalis and divided into four treatment groups using NaOCl, AromaRoot, and 980 nm laser, either alone or in combination. Bacterial counts were measured as colony-forming units per milliliter (CFU/mL). For smear layer analysis, 56 extracted teeth were prepared and irrigated using EDTA, AromaRoot, and laser activation, followed by scanning electron microscopy to evaluate dentinal tubule exposure. Data were analyzed using Kruskal–Wallis and ANOVA. Results: The combination of AromaRoot, NaOCl, and laser activation achieved a 99.00% bacterial reduction (from 8082 to 60 CFU/mL, p < 0.001), outperforming NaOCl alone (98.34%, 131 CFU/mL). For smear layer removal, AromaRoot with laser achieved 78.5% open dentinal tubules in the apical third, significantly higher than EDTA alone (64.5%, p < 0.05), though EDTA remained superior in the coronal third (89.0% vs. 81.0%, p > 0.05). Conclusions: The SMART technique significantly improves both disinfection and smear layer removal in root canal therapy, particularly in the apical region. These findings suggest that AromaRoot, especially when laser-activated, may serve as a safe and effective alternative to conventional irrigants, warranting further clinical evaluation. Full article
(This article belongs to the Special Issue New Research on Endodontic Therapy)
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