Special Issue "Block Copolymers for Drug Carriers/Vehicles"

A special issue of Materials (ISSN 1996-1944). This special issue belongs to the section "Biomaterials".

Deadline for manuscript submissions: 31 July 2020.

Special Issue Editor

Prof. Kwon Taek Lim
Website
Guest Editor
Department of Display Engineering, Pukyong National University
Interests: block copolymer; drug delivery system; micelles; stimuli responsive; functional polymer; hydrogels

Special Issue Information

Dear Colleagues,

The past decade has witnessed great advancement in the design and synthesis of block copolymers in biomedical applications, especially for the intracellular delivery of therapeutic agents. With the understanding of disease pathology, various strategies have been gradually established for guiding the preparation of novel drug formulations. Block copolymer-based carriers are one of the most versatile techniques in recent years because of its ability to solve the challenges associated with delivering poor solubility of therapeutic compounds. Block copolymers with an amphiphilic nature are known to self-assemble in an aqueous medium into polymeric micelles with a micro- to nanosize range, which are characterized by their unique core–shell architecture. Space created inside the micelle core can be used for transportation of drug molecules of hydrophobic nature, low solubility in blood, and with numerous side effects to the human body, especially those for cancer treatments.

The advent of modern macromolecular synthesis tools such as living radical polymerizations and various “click” chemistry strategies was simultaneously employed for the synthesis of various stimuli-responsive block copolymers. Recently, plenty of nanosized drug delivery vehicles were engineered from stimuli-responsive block copolymers to release their therapeutic cargo into pathological sites according to specific intracellular stimuli triggers.

The design of drug delivery vehicles requires taking care of all these aspects, and then something useful can come out for commercial use, which is still the driving force in this field. In view of this vast scenario of applications, researchers continue to propose new block copolymers characterized by improved features and biocompatibility, as well as innovative applications.

This issue aims to introduce the current state-of-the-art concerning polymeric drug delivery systems and to envision future perspectives. The topical subjects to be addressed include synthetic block polymers, natural polymers, bioconjugation of polymers, stimuli-responsive block copolymers, bioactive polymers, smart polymers, nanogels, hydrogels, the dynamics of polymers crossing biological barriers, targeted drug delivery, etc.

Considering your prominent contribution in this research area, I would like to invite you to submit high-quality original communications, full-length research articles, and reviews for this Special Issue.

Prof. Kwon Taek Lim
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Materials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Block copolymers
  • Drug delivery
  • Stimuli-responsive
  • Stimuli-triggered
  • Micelles
  • Nanogels
  • Cross-linked micelles
  • Hydrogels
  • Biocompatible
  • Targeted drug delivery
  • Nanomedicines

Published Papers

This special issue is now open for submission, see below for planned papers.

Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

(1) Synthesis and doxorubicin-loaded amphiphilic poly(D,L-lactide-co-glycolide)-b-poly(N-acryloylmorpholine) AB2 miktoarm star block copolymers for anticancer drug delivery

Kalyan Ramesha, Eun-Ji Joungb, Hyeung-Rak Kimb, Kwon Taek Lima,*

aDepartment of Display Engineering, Pukyong National University, Busan 48513, Republic of Korea.

bDepartment of Food Science and Nutrition, Pukyong National University, Busan 48513, Republic of Korea.

*Corresponding author: E-mail address: [email protected] (K.T. Lim).

(2) Near-infrared responsive, core cross-linked micelles of poly(ethylene oxide)-b-poly(glycidyl methacrylate) prepared via click chemistry for controlled drug release

Sonita A.P. Siboroa, Sabrina A. Salmab, Eun-Ji Joungc, Hyeung-Rak Kimc, Kwon Taek Lima,*

aDepartment of Display Engineering, Pukyong National University, Busan 48513, Republic of Korea.

bDepartment of Polymer Engineering, Pukyong National University, Busan 48513, Republic of Korea.

cDepartment of Food Science and Nutrition, Pukyong National University, Busan 48513, Republic of Korea.

*Corresponding author: E-mail address: [email protected] (K.T. Lim).

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