Antimicrobial and Antioxidant Activities of Natural Compounds and Synthetic Derivatives: Pharmacological Screening and Mechanism of Action
A special issue of Antibiotics (ISSN 2079-6382). This special issue belongs to the section "Novel Antimicrobial Agents".
Deadline for manuscript submissions: closed (1 October 2021) | Viewed by 10944
Special Issue Editors
Interests: bacteria and yeast infections; RAPD analysis of fungal and bacteria community; bacterial resistance; MDR; antimicrobial peptides; natural compounds and their antimicrobial activity; biofilm
Interests: bacterial and fungal mechanisms of persistence in the host; molecular epidemiology and characterization of antibiotic resistance determinants in bacteria of clinical interest; antibacterial and antifungal effects of unconventional antimicrobial agents
Interests: isolation and structure elucidation of natural compounds from microorganisms and plants; synthesis and derivatization of natural products; chromatographic techniques; analytical and spectroscopic techniques
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Special Issue Information
Dear Colleagues,
Antimicrobial agents have represented a very powerful tool in the clinical management of infectious diseases since their first discovery in the early 20th century. However, the growing number of multi-drug resistant microorganisms has drastically reduced antibiotic efficacy, due also to their not always appropriate or excessive use. In the last few decades, only a few new antibiotics have been introduced, leading to depleted antibiotic reserves and, thus, reduced possibility to manage multi-resistant infections. This new scenario has forced worldwide research into the screening of new antimicrobials.
Oxidative stress occurs when there is an imbalance between free radical activity and antioxidant defence activity. When functioning properly, free radicals can help fight off pathogens, but if in excess they can contribute to the pathophysiology of several chronic diseases, such as cancer, diabetes, and neurodegenerative and cardiovascular diseases. In recent years, it has been shown that some infections also cause oxidative stress.
Natural products from plants, fungi and bacteria have been successfully used in the past for their antimicrobial and antioxidant activity. Many bacteria or yeast metabolites have been used as starting chemical skeletons for the generation of semi-synthetic drugs with improved biological activity. However, the search for new compounds with antimicrobial and antioxidant properties remains an area still largely to be explored.
The goal of this Special Issue is the exploration of new compounds of natural origin, but also their analogues of synthesis, to develop new and urgently needed antimicrobial and antioxidant therapies.
Prof. Elisabetta Buommino
Prof. Maria Rosaria Catania
Prof. Marina DellaGreca
Guest Editors
Manuscript Submission Information
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Keywords
- New natural antimicrobial compounds
- Synthetic natural product derivatives
- Antimicrobial effects (included anti biofilm activity)
- Joint antimicrobial and antioxidant properties
- Molecular mechanisms of novel compounds
- Activity as disinfectants
- Clinical applications
- Multidrug resistant strains
- Discovery of novel therapies to overcome known antimicrobial resistance mechanisms and/or to restore susceptibility to conventional antibiotics (synergistic effect)
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