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Marine Drugs
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Selected Papers from the 2nd International Conference of Marine Fungal...
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Selected Papers from the 2nd International Conference of Marine Fungal Natural Products (MaFNaP_2017)

A special issue of Marine Drugs (ISSN 1660-3397).

Deadline for manuscript submissions: closed (31 May 2019) | Viewed by 18587

Special Issue Editors

Prof. Dr. Deniz Tasdemir

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Guest Editor
Marine Natural Products Chemistry Research Unit, GEOMAR Helmholtz Centre for Ocean Research Kiel, Am Kiel-Kanal 44, 24106 Kiel, Germany
Interests: marine natural product chemistry; marine microbiology; deep-sea organisms; structure elucidation; bioactivity; cancer; infectious diseases
Special Issues, Collections and Topics in MDPI journals
Dr. Catherine Roullier

E-Mail Website
Guest Editor
MMS (Mer Molécules Santé) – EA2160, IUML - Institut Universitaire Mer et Littoral - FR 3473 CNRS, University of Nantes – Pharmacy Faculty 9 rue Bias, BP 61112, 44035 Nantes-cedex 1, France
Interests: natural products chemistry; metabolomics; bioactivity; marine fungi; halogenated secondary metabolites; mass spectrometry; bioinformatics
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Fungi have played a significant role in both ancient and modern biotechnology. Not only products, such as the blockbuster antibiotics and anticancer drugs, alcohols, enzymes, organic acids, but also many processes, including baking or brewing heavily use fungi. Filamentous fungi from marine resources are recently emerging as excellent resources for cutting edge research and numerous applications (health, food, cosmetics, biofuels, etc.). However, we still know very little about marine fungi and their natural products (MaFNaPs). A comprehensive and interdisciplinary research is urgently needed.

The 2nd MaFNaP conference was organized in Kiel (Germany) by GEOMAR Centre for Marine Biotechnology (GEOMAR-Biotech) - Research Unit Marine Natural Products Chemistry (GEOMAR Helmholtz Centre for Ocean Research Kiel) on 27-29 June 2017. The initiative for a systematic work on marine fungi and MaFNaPs stems from the meeting of scientists in Prince Edward Island, Canada, that was followed by the official establishment of the MaFNaP Consortium in 2014. The very first MaFNaP conference was held in 2015 and hosted by the Faculty of Pharmacy of the University of Nantes (France). A Marine Drugs Special Issue comprising selected papers from this conference are available at https://www.mdpi.com/journal/marinedrugs/special_issues/fungal-consortium. The 2nd MaFNaP_2017 conference in Kiel has stimulated scientific interactions, networking and collaborations for innovative research to reveal the real capacity of marine fungi.

The MaFNaP_2017 conference topics were diverse and include many subjects that are highly relevant and complementary to marine fungal products, including marine fungal biodiversity, cultivability, genomics, epigenetics, ecology and physiology, marine fungal interactions, chemodiversity, analytics and metabolomics, biodiscovery and biotechnology.

MaFNaP conferences are dedicated to bring together marine fungal research community together. On behalf of the MaFNaP consortium and the scientific committee of the MaFNaP_2017 conference, we kindly invite submission in these topics, plus any topic related to marine fungal natural products.

MaFNaP_2017 Web Site: http://www.geomar.de/en/research/fb3/fb3-mn/symposia/mafnap2017/#c27886

Marine Fungal Natural Products Consortium: http://www.mafnap.org/

Prof. Dr. Deniz Tasdemir
Dr. Catherine Roullier
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Marine Drugs is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Marine fungi
  • Marine fungal natural products

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Published Papers (3 papers)

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Research

10 pages, 1398 KiB  
Article
Discovery of Primarolides A and B from Marine Fungus Asteromyces cruciatus Using Osmotic Stress and Treatment with Suberoylanilide Hydroxamic Acid
by Hope A. Igboeli, Douglas H. Marchbank, Hebelin Correa, David Overy and Russell G. Kerr
Mar. Drugs 2019, 17(8), 435; https://doi.org/10.3390/md17080435 - 24 Jul 2019
Cited by 14 | Viewed by 3641
Abstract
Advances in whole-genome sequencing of many fungal species has revealed the presence of numerous “silent” biosynthetic genes, highlighting their potential to produce a wide variety of natural products. These silent biosynthetic genes are regulated in part by their highly condensed chromatin structure, which [...] Read more.
Advances in whole-genome sequencing of many fungal species has revealed the presence of numerous “silent” biosynthetic genes, highlighting their potential to produce a wide variety of natural products. These silent biosynthetic genes are regulated in part by their highly condensed chromatin structure, which can be modified to allow transcription in response to external stimuli. In this study, Asteromyces cruciatus was subjected to both epigenetic modification and osmotic stress to enhance the production of new natural products. This “cooperative induction” strategy led to the isolation and characterization of two new polyketides from a fermentation of A. cruciatus treated with suberoylanilide hydroxamic acid and sodium chloride. The metabolic profiles of the control and treated samples were assessed using ultra-high performance liquid chromatography high-resolution electrospray ionization mass spectrometry (UHPLC-HRESIMS) metabolomic analysis, highlighting the upregulation of two new polyketides, primarolides A and B. These compounds were purified using reversed-phase flash chromatography followed by high-performance liquid chromatography, and their planar structures were established using NMR spectroscopy. Full article
(This article belongs to the Special Issue Selected Papers from the 2nd International Conference of Marine Fungal Natural Products (MaFNaP_2017))
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24 pages, 4433 KiB  
Article
Rapid Metabolome and Bioactivity Profiling of Fungi Associated with the Leaf and Rhizosphere of the Baltic Seagrass Zostera marina
by Lars-Erik Petersen, Michael Marner, Antje Labes and Deniz Tasdemir
Mar. Drugs 2019, 17(7), 419; https://doi.org/10.3390/md17070419 - 19 Jul 2019
Cited by 19 | Viewed by 6111
Abstract
Zostera marina (eelgrass) is a marine foundation species with key ecological roles in coastal habitats. Its bacterial microbiota has been well studied, but very little is known about its mycobiome. In this study, we have isolated and identified 13 fungal strains, dominated by [...] Read more.
Zostera marina (eelgrass) is a marine foundation species with key ecological roles in coastal habitats. Its bacterial microbiota has been well studied, but very little is known about its mycobiome. In this study, we have isolated and identified 13 fungal strains, dominated by Penicillium species (10 strains), from the leaf and the root rhizosphere of Baltic Z. marina. The organic extracts of the fungi that were cultured by an OSMAC (One-Strain–Many-Compounds) regime using five liquid culture media under both static and shaking conditions were investigated for their chemical and bioactivity profiles. All extracts showed strong anti-quorum sensing activity, and the majority of the Penicillium extracts displayed antimicrobial or anti-biofilm activity against Gram-negative environmental marine and human pathogens. HPLC-DAD-MS-based rapid metabolome analyses of the extracts indicated the high influence of culture conditions on the secondary metabolite (SM) profiles. Among 69 compounds detected in all Penicillium sp. extracts, 46 were successfully dereplicated. Analysis of SM relatedness in culture conditions by Hierarchical Cluster Analysis (HCA) revealed generally low similarity and showed a strong effect of medium selection on chemical profiles of Penicillium sp. This is the first study assessing both the metabolite and bioactivity profile of the fungi associated with Baltic eelgrass Z. marina. Full article
(This article belongs to the Special Issue Selected Papers from the 2nd International Conference of Marine Fungal Natural Products (MaFNaP_2017))
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25 pages, 4016 KiB  
Article
Influence of OSMAC-Based Cultivation in Metabolome and Anticancer Activity of Fungi Associated with the Brown Alga Fucus vesiculosus
by Bicheng Fan, Delphine Parrot, Martina Blümel, Antje Labes and Deniz Tasdemir
Mar. Drugs 2019, 17(1), 67; https://doi.org/10.3390/md17010067 - 19 Jan 2019
Cited by 32 | Viewed by 8286
Abstract
The fungi associated with marine algae are prolific sources of metabolites with high chemical diversity and bioactivity. In this study, we investigated culture-dependent fungal communities associated with the Baltic seaweed Fucus vesiculosus. Altogether, 55 epiphytic and endophytic fungi were isolated and identified. [...] Read more.
The fungi associated with marine algae are prolific sources of metabolites with high chemical diversity and bioactivity. In this study, we investigated culture-dependent fungal communities associated with the Baltic seaweed Fucus vesiculosus. Altogether, 55 epiphytic and endophytic fungi were isolated and identified. Twenty-six strains were selected for a small-scale One-Strain-Many-Compounds (OSMAC)-based fermentation in four media under solid and liquid culture regimes. In total, 208 fungal EtOAc extracts were tested for anticancer activity and general cytotoxicity. Ten most active strains (i.e., 80 extracts) were analyzed for their metabolome by molecular networking (MN), in-silico MS/MS fragmentation analysis (ISDB–UNPD), and manual dereplication. Thirty-six metabolites belonging to 25 chemical families were putatively annotated. The MN clearly distinguished the impact of culture conditions in chemical inventory and anticancer activity of the fungal extracts that was often associated with general toxicity. The bioactivity data were further mapped into MN to seek metabolites exclusively expressed in the active extracts. This is the first report of cultivable fungi associated with the Baltic F. vesiculosus that combined an OSMAC and an integrated MN-based untargeted metabolomics approaches for efficient assessment and visualization of the impact of the culture conditions on chemical space and anticancer potential of the fungi. Full article
(This article belongs to the Special Issue Selected Papers from the 2nd International Conference of Marine Fungal Natural Products (MaFNaP_2017))
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